Differences in the sensitivity of behavioural measures of pain to the selectivity of cyclo-oxygenase inhibitors

Abstract Objectives Freund’s complete adjuvant (FCA) is an animal model of inflammatory pain commonly used in the screening of COX-inhibitors. However, there is little understanding of how behavioural measures of the anti-inflammatory effect in the FCA model correlate to differences in mechanism of...

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Veröffentlicht in:	European journal of pain 2009-05, Vol.13 (5), p.448-457
Hauptverfasser:	Huntjens, Dymphy R.H, Spalding, David J.M, Danhof, Meindert, Della Pasqua, Oscar E
Format:	Artikel
Sprache:	eng
Schlagworte:	Allodynia Anesthesia & Perioperative Care Animals Behavior, Animal - drug effects Behavior, Animal - physiology Biomarker Biomarkers - analysis Biomarkers - blood COX-inhibitors Cyclooxygenase 1 - metabolism Cyclooxygenase 2 - drug effects Cyclooxygenase 2 - metabolism Cyclooxygenase Inhibitors - pharmacology Cyclooxygenase Inhibitors - therapeutic use Dinoprostone - antagonists & inhibitors Dinoprostone - biosynthesis Disease Models, Animal Drug Evaluation, Preclinical - methods Drug screening Endpoint Determination - methods Freund's Adjuvant - pharmacology Freund's complete adjuvant Hyperalgesia In vivo pharmacology Inflammation - drug therapy Inflammation - enzymology Inflammation - physiopathology Inflammation Mediators Inflammatory pain Male Membrane Proteins - antagonists & inhibitors Membrane Proteins - metabolism NSAIDs Pain - diagnosis Pain - drug therapy Pain - enzymology Pain Measurement - drug effects Pain Measurement - methods Pain Medicine Pain Threshold - drug effects Pain Threshold - physiology Rats Rats, Sprague-Dawley Sensitivity and Specificity Thromboxane B2 - antagonists & inhibitors Thromboxane B2 - metabolism Time Factors
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