Merkel cell carcinoma of the skin: pathological and molecular evidence for a causative role of MCV in oncogenesis

Merkel cell carcinoma (MCC), a skin tumour with neuroendocrine features, was recently found to be associated with a new type of human polyomavirus, called Merkel cell virus (MCV). We investigated the specificity of this association as well as a causal role of MCV in oncogenesis. DNA and RNA from ten...

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Veröffentlicht in:	The Journal of pathology 2009-05, Vol.218 (1), p.48-56
Hauptverfasser:	Sastre-Garau, Xavier, Peter, Martine, Avril, Marie-Françoise, Laude, Hélène, Couturier, Jérôme, Rozenberg, Flore, Almeida, Anna, Boitier, Françoise, Carlotti, Agnès, Couturaud, Benoıt, Dupin, Nicolas
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biological and medical sciences Carcinoma, Merkel Cell - pathology Carcinoma, Merkel Cell - virology Comparative Genomic Hybridization Dermatology DNA, Viral - analysis Female Gene Expression Regulation, Neoplastic human polyomavirus Humans In Situ Hybridization, Fluorescence Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Merkel cell carcinoma Merkel cell virus Merkel Cells - pathology Merkel Cells - virology Middle Aged Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Polyomavirus Polyomavirus - pathogenicity Polyomavirus Infections - complications RNA, Viral - analysis Skin Neoplasms - pathology Skin Neoplasms - virology small T oncogene Tumors of the skin and soft tissue. Premalignant lesions viral integration viral oncogenesis Virus Integration Virus Replication
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