Frequent Gross Deletion in the HIV Type 1 nef Gene in Hemophiliacs Treated with Korean Red Ginseng : Inhibition of Detection by Highly Active Antiretroviral Therapy
Twenty hemophiliacs were infected with Korean subclade B (KSB) of HIV-1 from two cash-paid plasma donors in Korea in 1990. Our previous studies revealed that Korean red ginseng (KRG) intake increases the frequency of gross deletion in the nef gene (gDeltanef). We investigated whether KRG and highly...
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| Veröffentlicht in: | AIDS research and human retroviruses 2009-04, Vol.25 (4), p.419-424 |
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| creator | YOUNG KEOL CHO YOU SUN JUNG SUNG, Heungsup |
| description | Twenty hemophiliacs were infected with Korean subclade B (KSB) of HIV-1 from two cash-paid plasma donors in Korea in 1990. Our previous studies revealed that Korean red ginseng (KRG) intake increases the frequency of gross deletion in the nef gene (gDeltanef). We investigated whether KRG and highly active antiretroviral therapy (HAART) affected the frequency of gDeltanef in the 20 hemophiliacs who share common characteristics of the HIV-1 source, mode of transmission, and infection time. Over a 10-year period, we obtained 522 nef amplicons by nested PCR using 172 samples of peripheral blood mononuclear cells. Of the 522 nef amplicons, 69 (13.2%) were gDeltanef. Despite a 2-fold higher monthly dose of KRG, the frequency of gDeltanef detection (3.2%) was significantly reduced during HAART compared with that prior to HAART (20.6%) (p < 0.001). gDeltanef was detected significantly more in patients treated with a monthly KRG intake of more than 60 g (26.8%) than in patients treated with a monthly KRG intake of less than 60 g (10.5%) (p < 0.05). These finding suggest that the frequency of gDeltanef is dependent on the amount of KRG intake, although further study is needed. These data might provide a new perspective on the pathogenesis of HIV-1. |
| doi_str_mv | 10.1089/aid.2008.0178 |
| format | Article |
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Our previous studies revealed that Korean red ginseng (KRG) intake increases the frequency of gross deletion in the nef gene (gDeltanef). We investigated whether KRG and highly active antiretroviral therapy (HAART) affected the frequency of gDeltanef in the 20 hemophiliacs who share common characteristics of the HIV-1 source, mode of transmission, and infection time. Over a 10-year period, we obtained 522 nef amplicons by nested PCR using 172 samples of peripheral blood mononuclear cells. Of the 522 nef amplicons, 69 (13.2%) were gDeltanef. Despite a 2-fold higher monthly dose of KRG, the frequency of gDeltanef detection (3.2%) was significantly reduced during HAART compared with that prior to HAART (20.6%) (p < 0.001). gDeltanef was detected significantly more in patients treated with a monthly KRG intake of more than 60 g (26.8%) than in patients treated with a monthly KRG intake of less than 60 g (10.5%) (p < 0.05). These finding suggest that the frequency of gDeltanef is dependent on the amount of KRG intake, although further study is needed. These data might provide a new perspective on the pathogenesis of HIV-1.</description><identifier>ISSN: 0889-2229</identifier><identifier>EISSN: 1931-8405</identifier><identifier>DOI: 10.1089/aid.2008.0178</identifier><identifier>PMID: 19320564</identifier><identifier>CODEN: ARHRE7</identifier><language>eng</language><publisher>New Rochelle, NY: Liebert</publisher><subject>Adolescent ; Adult ; AIDS/HIV ; Antiretroviral Therapy, Highly Active ; Biological and medical sciences ; Causes of ; Child ; Child, Preschool ; Disease transmission ; Drug therapy ; Fundamental and applied biological sciences. 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Our previous studies revealed that Korean red ginseng (KRG) intake increases the frequency of gross deletion in the nef gene (gDeltanef). We investigated whether KRG and highly active antiretroviral therapy (HAART) affected the frequency of gDeltanef in the 20 hemophiliacs who share common characteristics of the HIV-1 source, mode of transmission, and infection time. Over a 10-year period, we obtained 522 nef amplicons by nested PCR using 172 samples of peripheral blood mononuclear cells. Of the 522 nef amplicons, 69 (13.2%) were gDeltanef. Despite a 2-fold higher monthly dose of KRG, the frequency of gDeltanef detection (3.2%) was significantly reduced during HAART compared with that prior to HAART (20.6%) (p < 0.001). gDeltanef was detected significantly more in patients treated with a monthly KRG intake of more than 60 g (26.8%) than in patients treated with a monthly KRG intake of less than 60 g (10.5%) (p < 0.05). These finding suggest that the frequency of gDeltanef is dependent on the amount of KRG intake, although further study is needed. These data might provide a new perspective on the pathogenesis of HIV-1.</description><subject>Adolescent</subject><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>Biological and medical sciences</subject><subject>Causes of</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Disease transmission</subject><subject>Drug therapy</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene mutations</subject><subject>Genes, nef - genetics</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Hemophilia A - complications</subject><subject>Hemophilia A - drug therapy</subject><subject>Highly active antiretroviral therapy</subject><subject>HIV infection</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - drug therapy</subject><subject>HIV-1 - drug effects</subject><subject>HIV-1 - genetics</subject><subject>Human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Korea</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>nef Gene Products, Human Immunodeficiency Virus - genetics</subject><subject>Panax</subject><subject>Phytotherapy - methods</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Retrovirus</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Deletion - drug effects</subject><subject>Viral diseases</subject><subject>Virology</subject><subject>Young Adult</subject><issn>0889-2229</issn><issn>1931-8405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFklGLEzEQxxdRvPP00VcJyPm2Nclu0sS3cnpt8UCQ6usym510I9tsTdKTfh8_qNlrUQRB8jD8Z34zCZN_UbxkdMao0m_BdTNOqZpRNlePikumK1aqmorHxSVVSpecc31RPIvxG6VUcy6eFhcZ4lTI-rL4eRvw-wF9Isswxkje44DJjZ44T1KPZLX-SjbHPRJGPFqyRI9TaYW7cd-7wYGJZBMQEnbkh0s9-Thm5cnnrJfOR_Rb8o6sfe9a9zB3tPmOhOZBtEeyctt-OJJFTtwjWfjkAqYw3rsAA9n0GGB_fF48sTBEfHGOV8WX2w-bm1V592m5vlnclaZmOpWgpOHUWkBaW2s6ELIVzEKroZIM21aCrrQSnVa6Zq3pmADUUkgJoq1ZVV0Vb05z92HMS4mp2blocBjA43iIjZwzTuda_RfkVEmpapHB1ydwCwM2ztsxBTAT3CyYVjUTVNSZmv2DyqfDnTNjXrzL-b8aylODmT4toG32we0gHBtGm8kWTbZFM9mimWyR-Vfn9x7aHXZ_6LMPMnB9BiAaGGwAb1z8zXFWzSVjsvoF_ju_1g</recordid><startdate>20090401</startdate><enddate>20090401</enddate><creator>YOUNG KEOL CHO</creator><creator>YOU SUN JUNG</creator><creator>SUNG, Heungsup</creator><general>Liebert</general><general>Mary Ann Liebert, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20090401</creationdate><title>Frequent Gross Deletion in the HIV Type 1 nef Gene in Hemophiliacs Treated with Korean Red Ginseng : Inhibition of Detection by Highly Active Antiretroviral Therapy</title><author>YOUNG KEOL CHO ; YOU SUN JUNG ; SUNG, Heungsup</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-a86c20ffae04ffcda56b51fab9a361ebb6a93985d98941bcd15ae96566a5b4133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Antiretroviral Therapy, Highly Active</topic><topic>Biological and medical sciences</topic><topic>Causes of</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Disease transmission</topic><topic>Drug therapy</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene mutations</topic><topic>Genes, nef - genetics</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Hemophilia A - complications</topic><topic>Hemophilia A - drug therapy</topic><topic>Highly active antiretroviral therapy</topic><topic>HIV infection</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - drug therapy</topic><topic>HIV-1 - drug effects</topic><topic>HIV-1 - genetics</topic><topic>Human immunodeficiency virus 1</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Korea</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>nef Gene Products, Human Immunodeficiency Virus - genetics</topic><topic>Panax</topic><topic>Phytotherapy - methods</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Retrovirus</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Deletion - drug effects</topic><topic>Viral diseases</topic><topic>Virology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YOUNG KEOL CHO</creatorcontrib><creatorcontrib>YOU SUN JUNG</creatorcontrib><creatorcontrib>SUNG, Heungsup</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS research and human retroviruses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YOUNG KEOL CHO</au><au>YOU SUN JUNG</au><au>SUNG, Heungsup</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frequent Gross Deletion in the HIV Type 1 nef Gene in Hemophiliacs Treated with Korean Red Ginseng : Inhibition of Detection by Highly Active Antiretroviral Therapy</atitle><jtitle>AIDS research and human retroviruses</jtitle><addtitle>AIDS Res Hum Retroviruses</addtitle><date>2009-04-01</date><risdate>2009</risdate><volume>25</volume><issue>4</issue><spage>419</spage><epage>424</epage><pages>419-424</pages><issn>0889-2229</issn><eissn>1931-8405</eissn><coden>ARHRE7</coden><abstract>Twenty hemophiliacs were infected with Korean subclade B (KSB) of HIV-1 from two cash-paid plasma donors in Korea in 1990. Our previous studies revealed that Korean red ginseng (KRG) intake increases the frequency of gross deletion in the nef gene (gDeltanef). We investigated whether KRG and highly active antiretroviral therapy (HAART) affected the frequency of gDeltanef in the 20 hemophiliacs who share common characteristics of the HIV-1 source, mode of transmission, and infection time. Over a 10-year period, we obtained 522 nef amplicons by nested PCR using 172 samples of peripheral blood mononuclear cells. Of the 522 nef amplicons, 69 (13.2%) were gDeltanef. Despite a 2-fold higher monthly dose of KRG, the frequency of gDeltanef detection (3.2%) was significantly reduced during HAART compared with that prior to HAART (20.6%) (p < 0.001). gDeltanef was detected significantly more in patients treated with a monthly KRG intake of more than 60 g (26.8%) than in patients treated with a monthly KRG intake of less than 60 g (10.5%) (p < 0.05). These finding suggest that the frequency of gDeltanef is dependent on the amount of KRG intake, although further study is needed. These data might provide a new perspective on the pathogenesis of HIV-1.</abstract><cop>New Rochelle, NY</cop><pub>Liebert</pub><pmid>19320564</pmid><doi>10.1089/aid.2008.0178</doi><tpages>6</tpages></addata></record> |
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| ispartof | AIDS research and human retroviruses, 2009-04, Vol.25 (4), p.419-424 |
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| source | Mary Ann Liebert Online Subscription; MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult AIDS/HIV Antiretroviral Therapy, Highly Active Biological and medical sciences Causes of Child Child, Preschool Disease transmission Drug therapy Fundamental and applied biological sciences. Psychology Gene mutations Genes, nef - genetics Genetic aspects Health aspects Hemophilia A - complications Hemophilia A - drug therapy Highly active antiretroviral therapy HIV infection HIV Infections - complications HIV Infections - drug therapy HIV-1 - drug effects HIV-1 - genetics Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Korea Medical sciences Microbiology Miscellaneous nef Gene Products, Human Immunodeficiency Virus - genetics Panax Phytotherapy - methods Plant Extracts - pharmacology Plant Extracts - therapeutic use Retrovirus Sequence Analysis, DNA Sequence Deletion - drug effects Viral diseases Virology Young Adult |
| title | Frequent Gross Deletion in the HIV Type 1 nef Gene in Hemophiliacs Treated with Korean Red Ginseng : Inhibition of Detection by Highly Active Antiretroviral Therapy |
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