A rapid, fluorescence‐based assay for detecting antigenic modulation of the acetylcholine receptor on human cell lines

Background: Myasthenia gravis (MG) is an autoimmune disease affecting ∼40,000 patients in the United States. One of the major mechanisms of disease pathology in MG is the binding, internalization, and eventual destruction of acetylcholine receptors (AChR) at the neuromuscular junction by cross‐linki...

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Veröffentlicht in:	Cytometry. Part B, Clinical cytometry Clinical cytometry, 2009-05, Vol.76B (3), p.206-212
Hauptverfasser:	Keefe, Dennis, Hess, Donna, Bosco, Jennifer, Tzartos, Socrates, Powell, Jan, Lamsa, Justin, Josiah, Serene
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholine receptor Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Antigen-Antibody Reactions - drug effects Antigen-Antibody Reactions - immunology antigenic modulation Autoantibodies - immunology Cell Line Down-Regulation - drug effects flow cytometry Flow Cytometry - methods Fluorescence Humans myasthenia gravis Myasthenia Gravis - immunology Myasthenia Gravis - metabolism Receptors, Cholinergic - analysis Receptors, Cholinergic - immunology Sensitivity and Specificity Time Factors
Online-Zugang:	Volltext
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