Activin a promotes the TGF-beta-induced conversion of CD4+CD25- T cells into Foxp3+ induced regulatory T cells

TGF-beta induces the conversion of CD4(+)CD25(-) T cells into CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg). Activin A is a pleiotropic TGF-beta family member and is expressed in response to inflammatory signals. In this study, we report on the effects of activin A on the conversion of CD4(+)CD25(...

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Veröffentlicht in:	The Journal of immunology (1950) 2009-04, Vol.182 (8), p.4633-4640
Hauptverfasser:	Huber, Samuel, Stahl, Felix R, Schrader, Jörg, Lüth, Stefan, Presser, Katrin, Carambia, Antonella, Flavell, Richard A, Werner, Sabine, Blessing, Manfred, Herkel, Johannes, Schramm, Christoph
Format:	Artikel
Sprache:	eng
Schlagworte:	Activins - pharmacology Animals CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell Differentiation - drug effects Cell Differentiation - immunology Cells, Cultured Forkhead Transcription Factors - immunology Interleukin-2 Receptor alpha Subunit - immunology Mice Mice, Transgenic p38 Mitogen-Activated Protein Kinases - metabolism Smad2 Protein - metabolism Transforming Growth Factor beta - biosynthesis Transforming Growth Factor beta - immunology
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