The SWI SNF complex and cancer

The mammalian SWI/SNF complexes mediate ATP-dependent chromatin remodeling processes that are critical for differentiation and proliferation. Not surprisingly, loss of SWI/SNF function has been associated with malignant transformation, and a substantial body of evidence indicates that several compon...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2009-04, Vol.28 (14), p.1653-1668
Hauptverfasser:	Reisman, D, Glaros, S, Thompson, E A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - physiology Animals Apoptosis Biological and medical sciences Brahma-related gene BRG1 protein Cancer Catalytic subunits Cell Adhesion Cell Biology Cell Differentiation Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chromatin Chromatin Assembly and Disassembly Chromatin remodeling Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - physiology DNA Helicases - chemistry DNA Helicases - genetics DNA Helicases - physiology DNA Repair DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Drosophila Fundamental and applied biological sciences. Psychology Gene Expression Regulation Gene Silencing Genes Genetic aspects Human Genetics Humans Immune System - physiology Internal Medicine Loss of Heterozygosity Medicine Medicine & Public Health Molecular and cellular biology Neoplasms - genetics Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - physiology Nucleosomes Oncology Physiological aspects review SMARCB1 Protein Structure SWI/SNF complex Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - physiology Tumor suppressor genes Tumor Suppressor Proteins - physiology Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The mammalian SWI/SNF complexes mediate ATP-dependent chromatin remodeling processes that are critical for differentiation and proliferation. Not surprisingly, loss of SWI/SNF function has been associated with malignant transformation, and a substantial body of evidence indicates that several components of the SWI/SNF complexes function as tumor suppressors. This review summarizes the evidence that underlies this conclusion, with particular emphasis upon the two catalytic subunits of the SWI/SNF complexes, BRM, the mammalian ortholog of SWI2/SNF2 in yeast and brahma in Drosophila , and Brahma-related gene-1 (BRG1).
ISSN:	0950-9232 1476-5594
DOI:	10.1038/onc.2009.4