Attenuation of experimental autoimmune myocarditis by blocking T cell activation through 4-1BB pathway

Abstract 4-1BB, a member of the tumor necrosis factor receptor (TNFR) family, binds the 4-1BB ligand (4-1BBL), works as a costimulatory molecule, and regulates T cell-mediated immune responses. Although inflammation is an essential pathological feature of myocarditis, the role of 4-1BB in experiment...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2009-05, Vol.46 (5), p.719-727
Hauptverfasser:	Haga, Takaaki, Suzuki, Jun-ichi, Kosuge, Hisanori, Ogawa, Masahito, Saiki, Hitoshi, Haraguchi, Go, Maejima, Yasuhiro, Isobe, Mitsuaki, Uede, Toshimitsu
Format:	Artikel
Sprache:	eng
Schlagworte:	4-1BB 4-1BB Ligand - metabolism 4-1BB Ligand - pharmacology Animals Autoimmune Diseases - enzymology Autoimmune Diseases - immunology Autoimmune Diseases - pathology Autoimmune Diseases - prevention & control Cardiovascular Cell Proliferation - drug effects Costimulatory molecules Cytokines Cytokines - genetics Cytokines - metabolism Enzyme-Linked Immunosorbent Assay Gene Expression Regulation - drug effects Humans I-kappa B Kinase - metabolism Immunohistochemistry JNK Mitogen-Activated Protein Kinases - metabolism Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Male MAP kinase Myocarditis Myocarditis - enzymology Myocarditis - immunology Myocarditis - pathology Myocarditis - prevention & control Myocardium - enzymology Myocardium - pathology NF-κB p38 Mitogen-Activated Protein Kinases - metabolism Rats Rats, Inbred Lew RNA, Messenger - genetics RNA, Messenger - metabolism Sus scrofa T-Lymphocytes - cytology T-Lymphocytes - drug effects T-Lymphocytes - immunology Th1 Cells - metabolism Tumor Necrosis Factor Receptor Superfamily, Member 9 - metabolism
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