The EML4‐ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild‐type EGFR and KRAS

BACKGROUND: The echinoderm microtubule‐associated protein‐like 4‐anaplastic lymphoma kinase (EML4‐ALK) fusion gene resulting from the chromosome inversion inv(2)(p21;p23) recently was identified in nonsmall cell lung cancer (NSCLC). The authors of this study investigated the frequency, genetic and c...

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Veröffentlicht in:	Cancer 2009-04, Vol.115 (8), p.1723-1733
Hauptverfasser:	Wong, Daisy Wing‐Sze, Leung, Elaine Lai‐Han, So, Kimpton Kam‐Ting, Tam, Issan Yee‐San, Sihoe, Alan Dart‐Loon, Cheng, Lik‐Cheung, Ho, Kwok‐Keung, Au, Joseph Siu‐Kie, Chung, Lap‐Ping, Pik Wong, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Chromosome Breakage EGFR EML4‐ALK Female fusion gene Genes, ras Humans Lung Neoplasms - genetics Lung Neoplasms - pathology Male Medical sciences Middle Aged mucoepidermoid carcinoma Mutation nonsmall cell lung cancer nonsmoker Oncogene Proteins, Fusion - genetics Pneumology Receptor, Epidermal Growth Factor - genetics Smoking Tumors Tumors of the respiratory system and mediastinum
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