Distinct transcriptional outputs associated with mono- and dimethylated histone H3 arginine 2

Dimethylation of histone H3 Arg2 (H3R2me2) maintains transcriptional silencing by inhibiting Set1 mediated trimethylation of H3K4. Here we demonstrate that Arg2 is also monomethylated (H3R2me1) in yeast but that its functional characteristics are distinct from H3R2me2: (i) H3R2me1 does not inhibit h...

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Veröffentlicht in:	Nature structural & molecular biology 2009-04, Vol.16 (4), p.449-451
Hauptverfasser:	Kouzarides, Tony, Kirmizis, Antonis, Santos-Rosa, Helena, Penkett, Christopher J, Singer, Michael A, Green, Roland D
Format:	Artikel
Sprache:	eng
Schlagworte:	Arginine Arginine - metabolism Biochemistry Biological Microscopy Biomedical and Life Sciences brief-communication Gene expression Gene Expression Regulation, Fungal Genetic aspects Histones - metabolism Life Sciences Membrane Biology Methylation Molecular biology Physiological aspects Post-translational modification Protein Structure Saccharomyces cerevisiae - physiology Yeast Yeast fungi Yeasts
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