Brx shines a light on the route from hyperosmolarity to NFAT5

Nuclear factor of activated T cells 5 (NFAT5) is a member of the Rel family of transcription factors and is an essential inducer of osmoprotective gene products in mammalian cells. Its activation by hypertonicity requires p38 mitogen-activated protein kinase (MAPK) signaling and other pathways. A st...

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Veröffentlicht in:	Science signaling 2009-04, Vol.2 (65), p.pe20-pe20
Hauptverfasser:	Aramburu, Jose, López-Rodríguez, Cristina
Format:	Artikel
Sprache:	eng
Schlagworte:	A Kinase Anchor Proteins - metabolism Animals Gene Expression Regulation - physiology Humans Lymphocytes - metabolism Mice Minor Histocompatibility Antigens Models, Biological NFATC Transcription Factors - metabolism Osmolar Concentration Proto-Oncogene Proteins - metabolism Signal Transduction - physiology
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