Serum Antioxidants and Skin Cancer Risk: An 8-Year Community-Based Follow-up Study
Background: Antioxidant nutrients can help prevent skin damage caused by ultraviolet radiation from sunlight, but it is not clear whether serum concentrations of such nutrients influence skin cancer risk. Methods: We carried out a prospective study of the associations between serum concentrations of...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2009-04, Vol.18 (4), p.1167-1173 |
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| creator | VAN DER POLS, Jolieke C HEINEN, Mirjam M CELIA HUGHES, Maria IBIEBELE, Torukiri I MARKS, Geoffrey C GREEN, Adèle C |
| description | Background: Antioxidant nutrients can help prevent skin damage caused by ultraviolet radiation from sunlight, but it is not
clear whether serum concentrations of such nutrients influence skin cancer risk.
Methods: We carried out a prospective study of the associations between serum concentrations of antioxidant nutrients and
incidence (person-based and tumor-based) of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin among
a random subsample of 485 adults from an Australian community. Participants were divided into thirds, ranked according to
their serum concentrations of carotenoids, α-tocopherol, and selenium measured in 1996 and were monitored for incident, histologically
confirmed BCC and SCC tumors until 2004.
Results: Although there were no associations between baseline serum carotenoids or α-tocopherol concentrations and incidence
of BCC or SCC, baseline serum selenium concentrations showed strong inverse associations with both BCC and SCC tumor incidence.
Compared with participants with lowest selenium concentrations at baseline (0.4-1.0 μmol/L), those with the highest serum
selenium concentrations (1.3-2.8 μmol/L) had a decreased incidence of BCC tumors (multivariate relative risk, 0.43; 95% confidence
interval, 0.21-0.86; P trend = 0.02) and SCC tumors (multivariate relative risk, 0.36; 95% confidence interval, 0.15-0.82; P trend = 0.02).
Conclusion: Relatively high serum selenium concentrations are associated with an ∼60% decrease in subsequent tumor incidence
of both BCC and SCC, whereas serum concentrations of carotenoids or α-tocopherol are not associated with later skin cancer
incidence. A possible U-shaped association between serum selenium concentrations and SCC of the skin needs confirmation. (Cancer
Epidemiol Biomarkers Prev 2009;18(4):1167–73) |
| doi_str_mv | 10.1158/1055-9965.EPI-08-1211 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67114780</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67114780</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-d2546357b637e0da3808ea65f1c7661a4a8f0cd18ae4d667d324ea9090f473dd3</originalsourceid><addsrcrecordid>eNpF0E1PHCEYwHFi2vjWfgQbLjW9YHmG1_GmG60mJm1cPfREEBiXOi8rzMTut5ftrvYEIf8HyA-hI6AnAEJ_ByoEqWspTi5-XROqCVQAO2gfBNNEKSE-lP1bs4cOcv5DKVW1ELtoD2rGpOB8H93OQ5o6fNaPcfgbve3HjG3v8fwp9nhmexcSvo356bQkWJPfwSY8G7pu6uO4Iuc2B48vh7YdXsi0xPNx8qtP6GNj2xw-b9dDdH95cTe7Ijc_f1zPzm6I46BG4ivBJRPqQTIVqLdMUx2sFA04JSVYbnVDnQdtA_dSKs8qHmxNa9pwxbxnh-h4c-8yDc9TyKPpYnahbW0fhikbqQC40rSEYhO6NOScQmOWKXY2rQxQs8Y0ayizhjIF09ByUDDL3JftA9NDF_z_qa1eCb5uA5udbZtUvGJ-7yqQshZ1Vbpvm24RHxcvMQXj_smmkIunWxjQhpefSMVeASeniZk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67114780</pqid></control><display><type>article</type><title>Serum Antioxidants and Skin Cancer Risk: An 8-Year Community-Based Follow-up Study</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>American Association for Cancer Research</source><creator>VAN DER POLS, Jolieke C ; HEINEN, Mirjam M ; CELIA HUGHES, Maria ; IBIEBELE, Torukiri I ; MARKS, Geoffrey C ; GREEN, Adèle C</creator><creatorcontrib>VAN DER POLS, Jolieke C ; HEINEN, Mirjam M ; CELIA HUGHES, Maria ; IBIEBELE, Torukiri I ; MARKS, Geoffrey C ; GREEN, Adèle C</creatorcontrib><description>Background: Antioxidant nutrients can help prevent skin damage caused by ultraviolet radiation from sunlight, but it is not
clear whether serum concentrations of such nutrients influence skin cancer risk.
Methods: We carried out a prospective study of the associations between serum concentrations of antioxidant nutrients and
incidence (person-based and tumor-based) of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin among
a random subsample of 485 adults from an Australian community. Participants were divided into thirds, ranked according to
their serum concentrations of carotenoids, α-tocopherol, and selenium measured in 1996 and were monitored for incident, histologically
confirmed BCC and SCC tumors until 2004.
Results: Although there were no associations between baseline serum carotenoids or α-tocopherol concentrations and incidence
of BCC or SCC, baseline serum selenium concentrations showed strong inverse associations with both BCC and SCC tumor incidence.
Compared with participants with lowest selenium concentrations at baseline (0.4-1.0 μmol/L), those with the highest serum
selenium concentrations (1.3-2.8 μmol/L) had a decreased incidence of BCC tumors (multivariate relative risk, 0.43; 95% confidence
interval, 0.21-0.86; P trend = 0.02) and SCC tumors (multivariate relative risk, 0.36; 95% confidence interval, 0.15-0.82; P trend = 0.02).
Conclusion: Relatively high serum selenium concentrations are associated with an ∼60% decrease in subsequent tumor incidence
of both BCC and SCC, whereas serum concentrations of carotenoids or α-tocopherol are not associated with later skin cancer
incidence. A possible U-shaped association between serum selenium concentrations and SCC of the skin needs confirmation. (Cancer
Epidemiol Biomarkers Prev 2009;18(4):1167–73)</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.EPI-08-1211</identifier><identifier>PMID: 19336544</identifier><identifier>CODEN: CEBPE4</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Aged ; alpha-Tocopherol - blood ; antioxidants ; Antioxidants - metabolism ; Australia - epidemiology ; Biological and medical sciences ; biomarkers ; Biomarkers, Tumor - blood ; Carcinoma, Basal Cell - blood ; Carcinoma, Basal Cell - epidemiology ; Carcinoma, Squamous Cell - blood ; Carcinoma, Squamous Cell - epidemiology ; Carotenoids - blood ; Cohort Studies ; Dermatology ; Female ; Follow-Up Studies ; Humans ; Incidence ; Longitudinal Studies ; Male ; Medical sciences ; Middle Aged ; Prospective Studies ; prospective study ; Risk Assessment ; Selenium Compounds - blood ; skin neoplasms ; Skin Neoplasms - blood ; Skin Neoplasms - epidemiology ; Tumors ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2009-04, Vol.18 (4), p.1167-1173</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-d2546357b637e0da3808ea65f1c7661a4a8f0cd18ae4d667d324ea9090f473dd3</citedby><cites>FETCH-LOGICAL-c417t-d2546357b637e0da3808ea65f1c7661a4a8f0cd18ae4d667d324ea9090f473dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3342,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21669592$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19336544$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VAN DER POLS, Jolieke C</creatorcontrib><creatorcontrib>HEINEN, Mirjam M</creatorcontrib><creatorcontrib>CELIA HUGHES, Maria</creatorcontrib><creatorcontrib>IBIEBELE, Torukiri I</creatorcontrib><creatorcontrib>MARKS, Geoffrey C</creatorcontrib><creatorcontrib>GREEN, Adèle C</creatorcontrib><title>Serum Antioxidants and Skin Cancer Risk: An 8-Year Community-Based Follow-up Study</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Background: Antioxidant nutrients can help prevent skin damage caused by ultraviolet radiation from sunlight, but it is not
clear whether serum concentrations of such nutrients influence skin cancer risk.
Methods: We carried out a prospective study of the associations between serum concentrations of antioxidant nutrients and
incidence (person-based and tumor-based) of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin among
a random subsample of 485 adults from an Australian community. Participants were divided into thirds, ranked according to
their serum concentrations of carotenoids, α-tocopherol, and selenium measured in 1996 and were monitored for incident, histologically
confirmed BCC and SCC tumors until 2004.
Results: Although there were no associations between baseline serum carotenoids or α-tocopherol concentrations and incidence
of BCC or SCC, baseline serum selenium concentrations showed strong inverse associations with both BCC and SCC tumor incidence.
Compared with participants with lowest selenium concentrations at baseline (0.4-1.0 μmol/L), those with the highest serum
selenium concentrations (1.3-2.8 μmol/L) had a decreased incidence of BCC tumors (multivariate relative risk, 0.43; 95% confidence
interval, 0.21-0.86; P trend = 0.02) and SCC tumors (multivariate relative risk, 0.36; 95% confidence interval, 0.15-0.82; P trend = 0.02).
Conclusion: Relatively high serum selenium concentrations are associated with an ∼60% decrease in subsequent tumor incidence
of both BCC and SCC, whereas serum concentrations of carotenoids or α-tocopherol are not associated with later skin cancer
incidence. A possible U-shaped association between serum selenium concentrations and SCC of the skin needs confirmation. (Cancer
Epidemiol Biomarkers Prev 2009;18(4):1167–73)</description><subject>Aged</subject><subject>alpha-Tocopherol - blood</subject><subject>antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Australia - epidemiology</subject><subject>Biological and medical sciences</subject><subject>biomarkers</subject><subject>Biomarkers, Tumor - blood</subject><subject>Carcinoma, Basal Cell - blood</subject><subject>Carcinoma, Basal Cell - epidemiology</subject><subject>Carcinoma, Squamous Cell - blood</subject><subject>Carcinoma, Squamous Cell - epidemiology</subject><subject>Carotenoids - blood</subject><subject>Cohort Studies</subject><subject>Dermatology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Incidence</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>prospective study</subject><subject>Risk Assessment</subject><subject>Selenium Compounds - blood</subject><subject>skin neoplasms</subject><subject>Skin Neoplasms - blood</subject><subject>Skin Neoplasms - epidemiology</subject><subject>Tumors</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0E1PHCEYwHFi2vjWfgQbLjW9YHmG1_GmG60mJm1cPfREEBiXOi8rzMTut5ftrvYEIf8HyA-hI6AnAEJ_ByoEqWspTi5-XROqCVQAO2gfBNNEKSE-lP1bs4cOcv5DKVW1ELtoD2rGpOB8H93OQ5o6fNaPcfgbve3HjG3v8fwp9nhmexcSvo356bQkWJPfwSY8G7pu6uO4Iuc2B48vh7YdXsi0xPNx8qtP6GNj2xw-b9dDdH95cTe7Ijc_f1zPzm6I46BG4ivBJRPqQTIVqLdMUx2sFA04JSVYbnVDnQdtA_dSKs8qHmxNa9pwxbxnh-h4c-8yDc9TyKPpYnahbW0fhikbqQC40rSEYhO6NOScQmOWKXY2rQxQs8Y0ayizhjIF09ByUDDL3JftA9NDF_z_qa1eCb5uA5udbZtUvGJ-7yqQshZ1Vbpvm24RHxcvMQXj_smmkIunWxjQhpefSMVeASeniZk</recordid><startdate>20090401</startdate><enddate>20090401</enddate><creator>VAN DER POLS, Jolieke C</creator><creator>HEINEN, Mirjam M</creator><creator>CELIA HUGHES, Maria</creator><creator>IBIEBELE, Torukiri I</creator><creator>MARKS, Geoffrey C</creator><creator>GREEN, Adèle C</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090401</creationdate><title>Serum Antioxidants and Skin Cancer Risk: An 8-Year Community-Based Follow-up Study</title><author>VAN DER POLS, Jolieke C ; HEINEN, Mirjam M ; CELIA HUGHES, Maria ; IBIEBELE, Torukiri I ; MARKS, Geoffrey C ; GREEN, Adèle C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-d2546357b637e0da3808ea65f1c7661a4a8f0cd18ae4d667d324ea9090f473dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>alpha-Tocopherol - blood</topic><topic>antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Australia - epidemiology</topic><topic>Biological and medical sciences</topic><topic>biomarkers</topic><topic>Biomarkers, Tumor - blood</topic><topic>Carcinoma, Basal Cell - blood</topic><topic>Carcinoma, Basal Cell - epidemiology</topic><topic>Carcinoma, Squamous Cell - blood</topic><topic>Carcinoma, Squamous Cell - epidemiology</topic><topic>Carotenoids - blood</topic><topic>Cohort Studies</topic><topic>Dermatology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Incidence</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>prospective study</topic><topic>Risk Assessment</topic><topic>Selenium Compounds - blood</topic><topic>skin neoplasms</topic><topic>Skin Neoplasms - blood</topic><topic>Skin Neoplasms - epidemiology</topic><topic>Tumors</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VAN DER POLS, Jolieke C</creatorcontrib><creatorcontrib>HEINEN, Mirjam M</creatorcontrib><creatorcontrib>CELIA HUGHES, Maria</creatorcontrib><creatorcontrib>IBIEBELE, Torukiri I</creatorcontrib><creatorcontrib>MARKS, Geoffrey C</creatorcontrib><creatorcontrib>GREEN, Adèle C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VAN DER POLS, Jolieke C</au><au>HEINEN, Mirjam M</au><au>CELIA HUGHES, Maria</au><au>IBIEBELE, Torukiri I</au><au>MARKS, Geoffrey C</au><au>GREEN, Adèle C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Antioxidants and Skin Cancer Risk: An 8-Year Community-Based Follow-up Study</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2009-04-01</date><risdate>2009</risdate><volume>18</volume><issue>4</issue><spage>1167</spage><epage>1173</epage><pages>1167-1173</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><coden>CEBPE4</coden><abstract>Background: Antioxidant nutrients can help prevent skin damage caused by ultraviolet radiation from sunlight, but it is not
clear whether serum concentrations of such nutrients influence skin cancer risk.
Methods: We carried out a prospective study of the associations between serum concentrations of antioxidant nutrients and
incidence (person-based and tumor-based) of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin among
a random subsample of 485 adults from an Australian community. Participants were divided into thirds, ranked according to
their serum concentrations of carotenoids, α-tocopherol, and selenium measured in 1996 and were monitored for incident, histologically
confirmed BCC and SCC tumors until 2004.
Results: Although there were no associations between baseline serum carotenoids or α-tocopherol concentrations and incidence
of BCC or SCC, baseline serum selenium concentrations showed strong inverse associations with both BCC and SCC tumor incidence.
Compared with participants with lowest selenium concentrations at baseline (0.4-1.0 μmol/L), those with the highest serum
selenium concentrations (1.3-2.8 μmol/L) had a decreased incidence of BCC tumors (multivariate relative risk, 0.43; 95% confidence
interval, 0.21-0.86; P trend = 0.02) and SCC tumors (multivariate relative risk, 0.36; 95% confidence interval, 0.15-0.82; P trend = 0.02).
Conclusion: Relatively high serum selenium concentrations are associated with an ∼60% decrease in subsequent tumor incidence
of both BCC and SCC, whereas serum concentrations of carotenoids or α-tocopherol are not associated with later skin cancer
incidence. A possible U-shaped association between serum selenium concentrations and SCC of the skin needs confirmation. (Cancer
Epidemiol Biomarkers Prev 2009;18(4):1167–73)</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>19336544</pmid><doi>10.1158/1055-9965.EPI-08-1211</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer epidemiology, biomarkers & prevention, 2009-04, Vol.18 (4), p.1167-1173 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; American Association for Cancer Research |
| subjects | Aged alpha-Tocopherol - blood antioxidants Antioxidants - metabolism Australia - epidemiology Biological and medical sciences biomarkers Biomarkers, Tumor - blood Carcinoma, Basal Cell - blood Carcinoma, Basal Cell - epidemiology Carcinoma, Squamous Cell - blood Carcinoma, Squamous Cell - epidemiology Carotenoids - blood Cohort Studies Dermatology Female Follow-Up Studies Humans Incidence Longitudinal Studies Male Medical sciences Middle Aged Prospective Studies prospective study Risk Assessment Selenium Compounds - blood skin neoplasms Skin Neoplasms - blood Skin Neoplasms - epidemiology Tumors Tumors of the skin and soft tissue. Premalignant lesions |
| title | Serum Antioxidants and Skin Cancer Risk: An 8-Year Community-Based Follow-up Study |
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