HIF prolyl hydroxylase inhibition augments dopamine release in the rat brain in vivo

The transcription factor hypoxia‐inducible factor (HIF) is essential for the activation of several genes that promote the survival of cells exposed to oxidative stress. Expression of tyrosine hydroxylase (TH), which is the rate‐limiting enzyme in the dopamine (DA) synthesis, is one of the genes that...

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Veröffentlicht in:	Journal of neuroscience research 2009-05, Vol.87 (7), p.1686-1694
Hauptverfasser:	Witten, Louise, Sager, Thomas, Thirstrup, Kenneth, Johansen, Jens Leander, Larsen, Dorrit Bjerg, Montezinho, Liliana P., Mørk, Arne
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - drug effects Brain - metabolism Brain Stem - drug effects Brain Stem - metabolism Cobalt - pharmacology Cocaine - pharmacology Corpus Striatum - drug effects Corpus Striatum - metabolism dopamine Dopamine - metabolism Dopamine Uptake Inhibitors - pharmacology Enzyme Inhibitors - pharmacology Extracellular Space - metabolism Gene Expression - drug effects HIF prolyl hydroxylase HPH inhibitors Male microdialysis Motor Activity - drug effects Phenanthrolines - pharmacology Potassium - metabolism Procollagen-Proline Dioxygenase - antagonists & inhibitors Procollagen-Proline Dioxygenase - metabolism Rats Rats, Sprague-Dawley Rats, Wistar Tyrosine 3-Monooxygenase - metabolism tyrosine hydroxylase
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