Memory B-cells in healthy and antibody-deficient children
Abstract Recently it has become clear that a reduction of IgD-CD27+ memory B-cells in adult CVID patients correlates with clinical aspects of the disease. However, little is known about B-cell dysregulation in pediatric antibody deficiency. Reference values are essential for the interpretation of B-...
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| Veröffentlicht in: | Clinical immunology (Orlando, Fla.) Fla.), 2009-04, Vol.131 (1), p.50-59 |
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| creator | Huck, Kirsten Feyen, Oliver Ghosh, Sujal Beltz, Kathrin Bellert, Sven Niehues, Tim |
| description | Abstract Recently it has become clear that a reduction of IgD-CD27+ memory B-cells in adult CVID patients correlates with clinical aspects of the disease. However, little is known about B-cell dysregulation in pediatric antibody deficiency. Reference values are essential for the interpretation of B-cell subpopulations in children. We present the clinical and immunophenotypical characterization of 16 children and adolescents with CVID and hypogammaglobulinemia. Reference values for IgD+CD27-, IgD+CD27+ and IgD-CD27+ B-cells in healthy children were established for five age groups. In healthy controls we found a continuous increase in IgD-CD27+ B-cell percentage with age from 1.35–5% of B-cells in the second year of life to 4.1–18.7% in adolescents. Interestingly, in 12/14 antibody-deficient patients memory B-cells are significantly below the age-related 10th percentile. We conclude that the reduction of memory B-cells is a useful additional marker for the detection of children with CVID hypogammaglobulinemia and may contribute to the early presentation. |
| doi_str_mv | 10.1016/j.clim.2008.11.008 |
| format | Article |
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However, little is known about B-cell dysregulation in pediatric antibody deficiency. Reference values are essential for the interpretation of B-cell subpopulations in children. We present the clinical and immunophenotypical characterization of 16 children and adolescents with CVID and hypogammaglobulinemia. Reference values for IgD+CD27-, IgD+CD27+ and IgD-CD27+ B-cells in healthy children were established for five age groups. In healthy controls we found a continuous increase in IgD-CD27+ B-cell percentage with age from 1.35–5% of B-cells in the second year of life to 4.1–18.7% in adolescents. Interestingly, in 12/14 antibody-deficient patients memory B-cells are significantly below the age-related 10th percentile. We conclude that the reduction of memory B-cells is a useful additional marker for the detection of children with CVID hypogammaglobulinemia and may contribute to the early presentation.</description><identifier>ISSN: 1521-6616</identifier><identifier>EISSN: 1521-7035</identifier><identifier>DOI: 10.1016/j.clim.2008.11.008</identifier><identifier>PMID: 19162556</identifier><identifier>CODEN: CLIIFY</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adolescent ; Agammaglobulinemia - immunology ; Allergy and Immunology ; Antibody deficiency ; B-cell subsets ; B-Lymphocyte Subsets - immunology ; B-Lymphocytes - immunology ; Biological and medical sciences ; Child ; Child, Preschool ; Children ; Common variable immunodeficiency ; Common Variable Immunodeficiency - immunology ; CVID ; Female ; Flow Cytometry ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Hypogammaglobulinemia ; Immunologic Memory - immunology ; Immunophenotyping ; Infant ; Male ; Memory B-cells ; Reference Values</subject><ispartof>Clinical immunology (Orlando, Fla.), 2009-04, Vol.131 (1), p.50-59</ispartof><rights>Elsevier Inc.</rights><rights>2008 Elsevier Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4298-c53776bda7a95c81b973e6f252cc58635dc7dafce291836ebdce468378ef88e53</citedby><cites>FETCH-LOGICAL-c4298-c53776bda7a95c81b973e6f252cc58635dc7dafce291836ebdce468378ef88e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clim.2008.11.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21378399$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19162556$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huck, Kirsten</creatorcontrib><creatorcontrib>Feyen, Oliver</creatorcontrib><creatorcontrib>Ghosh, Sujal</creatorcontrib><creatorcontrib>Beltz, Kathrin</creatorcontrib><creatorcontrib>Bellert, Sven</creatorcontrib><creatorcontrib>Niehues, Tim</creatorcontrib><title>Memory B-cells in healthy and antibody-deficient children</title><title>Clinical immunology (Orlando, Fla.)</title><addtitle>Clin Immunol</addtitle><description>Abstract Recently it has become clear that a reduction of IgD-CD27+ memory B-cells in adult CVID patients correlates with clinical aspects of the disease. However, little is known about B-cell dysregulation in pediatric antibody deficiency. Reference values are essential for the interpretation of B-cell subpopulations in children. We present the clinical and immunophenotypical characterization of 16 children and adolescents with CVID and hypogammaglobulinemia. Reference values for IgD+CD27-, IgD+CD27+ and IgD-CD27+ B-cells in healthy children were established for five age groups. In healthy controls we found a continuous increase in IgD-CD27+ B-cell percentage with age from 1.35–5% of B-cells in the second year of life to 4.1–18.7% in adolescents. Interestingly, in 12/14 antibody-deficient patients memory B-cells are significantly below the age-related 10th percentile. We conclude that the reduction of memory B-cells is a useful additional marker for the detection of children with CVID hypogammaglobulinemia and may contribute to the early presentation.</description><subject>Adolescent</subject><subject>Agammaglobulinemia - immunology</subject><subject>Allergy and Immunology</subject><subject>Antibody deficiency</subject><subject>B-cell subsets</subject><subject>B-Lymphocyte Subsets - immunology</subject><subject>B-Lymphocytes - immunology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Common variable immunodeficiency</subject><subject>Common Variable Immunodeficiency - immunology</subject><subject>CVID</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Hypogammaglobulinemia</subject><subject>Immunologic Memory - immunology</subject><subject>Immunophenotyping</subject><subject>Infant</subject><subject>Male</subject><subject>Memory B-cells</subject><subject>Reference Values</subject><issn>1521-6616</issn><issn>1521-7035</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkuLFDEUhYM4OOPoH3AhtdFd1eQmnReIMA6-YIZZqOuQSm7RaesxJtVC_XtTdKHgQhfhZPGdm8PJJeQF0AYoyKtD4_s4NIxS3QA0RR6RCxAMakW5eLzdpQR5Tp7mfKCUCsbkE3IOBiQTQl4Qc4fDlJbqXe2x73MVx2qPrp_3S-XGUM4c2yksdcAu-ojjXPl97EPC8Rk561yf8fmml-Tbh_dfbz7Vt_cfP99c39Z-x4yuveBKyTY45YzwGlqjOMqOCea90JKL4FVwnUdmQHOJbfC4k5orjZ3WKPgleX2a-5CmH0fMsx1iXsO6EadjtlIBMMXgvyCjO81BygKyE-jTlHPCzj6kOLi0WKB2bdYe7NqsXZu1ALZIMb3cph_bAcMfy1ZlAV5tgMve9V1yo4_5N1cCKs2NKdybE4eltJ8Rk81rsR5DTOhnG6b47xxv_7IXZIzlxe-4YD5MxzSW77BgM7PUfll3YF0Bqik1tET4BSULqlI</recordid><startdate>200904</startdate><enddate>200904</enddate><creator>Huck, Kirsten</creator><creator>Feyen, Oliver</creator><creator>Ghosh, Sujal</creator><creator>Beltz, Kathrin</creator><creator>Bellert, Sven</creator><creator>Niehues, Tim</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200904</creationdate><title>Memory B-cells in healthy and antibody-deficient children</title><author>Huck, Kirsten ; Feyen, Oliver ; Ghosh, Sujal ; Beltz, Kathrin ; Bellert, Sven ; Niehues, Tim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4298-c53776bda7a95c81b973e6f252cc58635dc7dafce291836ebdce468378ef88e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Agammaglobulinemia - immunology</topic><topic>Allergy and Immunology</topic><topic>Antibody deficiency</topic><topic>B-cell subsets</topic><topic>B-Lymphocyte Subsets - immunology</topic><topic>B-Lymphocytes - immunology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Common variable immunodeficiency</topic><topic>Common Variable Immunodeficiency - immunology</topic><topic>CVID</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Fundamental and applied biological sciences. 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However, little is known about B-cell dysregulation in pediatric antibody deficiency. Reference values are essential for the interpretation of B-cell subpopulations in children. We present the clinical and immunophenotypical characterization of 16 children and adolescents with CVID and hypogammaglobulinemia. Reference values for IgD+CD27-, IgD+CD27+ and IgD-CD27+ B-cells in healthy children were established for five age groups. In healthy controls we found a continuous increase in IgD-CD27+ B-cell percentage with age from 1.35–5% of B-cells in the second year of life to 4.1–18.7% in adolescents. Interestingly, in 12/14 antibody-deficient patients memory B-cells are significantly below the age-related 10th percentile. 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| subjects | Adolescent Agammaglobulinemia - immunology Allergy and Immunology Antibody deficiency B-cell subsets B-Lymphocyte Subsets - immunology B-Lymphocytes - immunology Biological and medical sciences Child Child, Preschool Children Common variable immunodeficiency Common Variable Immunodeficiency - immunology CVID Female Flow Cytometry Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Hypogammaglobulinemia Immunologic Memory - immunology Immunophenotyping Infant Male Memory B-cells Reference Values |
| title | Memory B-cells in healthy and antibody-deficient children |
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