The DAS28 in rheumatoid arthritis and fibromyalgia patients
Objective. To compare the DAS28 (Disease Activity Score including a 28-joint count) values of rheumatoid arthritis (RA) and fibromyalgia (FM) patients, and to establish whether high pain levels and impaired mood influence DAS28 values. Methods. DAS28 values were calculated in 62 consecutive patients...
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| Veröffentlicht in: | British journal of rheumatology 2004-12, Vol.43 (12), p.1504-1507 |
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| container_title | British journal of rheumatology |
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| creator | Leeb, B. F. Andel, I. Sautner, J. Nothnagl, T. Rintelen, B. |
| description | Objective. To compare the DAS28 (Disease Activity Score including a 28-joint count) values of rheumatoid arthritis (RA) and fibromyalgia (FM) patients, and to establish whether high pain levels and impaired mood influence DAS28 values. Methods. DAS28 values were calculated in 62 consecutive patients with RA and in 26 patients suffering from FM. Values for DAS28 scores as well as for the single items of the patient cohorts were compared using Student's t-tests. To evaluate the item weighting and internal consistency of the total score factor analysis was performed and Cronbach's alpha calculated. Results. RA patients showed a mean DAS28 score of 4.23 (±1.2; range 0.77–7.46) and in FM patients the mean DAS28 came to 4.04 (±1.13; range 1.19–6.28). DAS28 values of RA and FM patients were not significantly different statistically. Comparing the single components of the score, however, highly significant differences (P |
| doi_str_mv | 10.1093/rheumatology/keh322 |
| format | Article |
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F. ; Andel, I. ; Sautner, J. ; Nothnagl, T. ; Rintelen, B.</creator><creatorcontrib>Leeb, B. F. ; Andel, I. ; Sautner, J. ; Nothnagl, T. ; Rintelen, B.</creatorcontrib><description>Objective. To compare the DAS28 (Disease Activity Score including a 28-joint count) values of rheumatoid arthritis (RA) and fibromyalgia (FM) patients, and to establish whether high pain levels and impaired mood influence DAS28 values. Methods. DAS28 values were calculated in 62 consecutive patients with RA and in 26 patients suffering from FM. Values for DAS28 scores as well as for the single items of the patient cohorts were compared using Student's t-tests. To evaluate the item weighting and internal consistency of the total score factor analysis was performed and Cronbach's alpha calculated. Results. RA patients showed a mean DAS28 score of 4.23 (±1.2; range 0.77–7.46) and in FM patients the mean DAS28 came to 4.04 (±1.13; range 1.19–6.28). DAS28 values of RA and FM patients were not significantly different statistically. Comparing the single components of the score, however, highly significant differences (P<0.0005) occurred between RA and FM patients. Cronbach's alpha for the DAS28 in RA patients amounted to 0.7329, indicating high internal consistency, whereas in FM patients it was 0.4832. Conclusion. The DAS28, as expected, proved to be inappropriate to express disease activity in FM patients. DAS28 values for expressing disease activity in RA patients may be flawed by coexisting FM and should therefore be regarded with caution as high pain levels more than impaired mood may lead to higher total scores.</description><identifier>ISSN: 1462-0324</identifier><identifier>ISSN: 1460-2172</identifier><identifier>EISSN: 1462-0332</identifier><identifier>EISSN: 1460-2172</identifier><identifier>DOI: 10.1093/rheumatology/keh322</identifier><identifier>PMID: 15252215</identifier><identifier>CODEN: BJRHDF</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antirheumatic Agents - therapeutic use ; Arthritis, Rheumatoid - diagnosis ; Arthritis, Rheumatoid - drug therapy ; Biological and medical sciences ; Disease activity measurement ; Diseases of the osteoarticular system ; Factor Analysis, Statistical ; Female ; Fibromyalgia ; Fibromyalgia - diagnosis ; Humans ; Inflammatory joint diseases ; Male ; Medical sciences ; Middle Aged ; Pain Measurement ; Reproducibility of Results ; Rheumatoid arthritis ; Severity of Illness Index</subject><ispartof>British journal of rheumatology, 2004-12, Vol.43 (12), p.1504-1507</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Dec 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-d0f861b2ef9e14b7dcd8997f2d96d784ca7599b319e7d7c7d8ab9429397d43a23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16337208$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15252215$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leeb, B. F.</creatorcontrib><creatorcontrib>Andel, I.</creatorcontrib><creatorcontrib>Sautner, J.</creatorcontrib><creatorcontrib>Nothnagl, T.</creatorcontrib><creatorcontrib>Rintelen, B.</creatorcontrib><title>The DAS28 in rheumatoid arthritis and fibromyalgia patients</title><title>British journal of rheumatology</title><addtitle>Rheumatology</addtitle><description>Objective. To compare the DAS28 (Disease Activity Score including a 28-joint count) values of rheumatoid arthritis (RA) and fibromyalgia (FM) patients, and to establish whether high pain levels and impaired mood influence DAS28 values. Methods. DAS28 values were calculated in 62 consecutive patients with RA and in 26 patients suffering from FM. Values for DAS28 scores as well as for the single items of the patient cohorts were compared using Student's t-tests. To evaluate the item weighting and internal consistency of the total score factor analysis was performed and Cronbach's alpha calculated. Results. RA patients showed a mean DAS28 score of 4.23 (±1.2; range 0.77–7.46) and in FM patients the mean DAS28 came to 4.04 (±1.13; range 1.19–6.28). DAS28 values of RA and FM patients were not significantly different statistically. Comparing the single components of the score, however, highly significant differences (P<0.0005) occurred between RA and FM patients. Cronbach's alpha for the DAS28 in RA patients amounted to 0.7329, indicating high internal consistency, whereas in FM patients it was 0.4832. Conclusion. The DAS28, as expected, proved to be inappropriate to express disease activity in FM patients. DAS28 values for expressing disease activity in RA patients may be flawed by coexisting FM and should therefore be regarded with caution as high pain levels more than impaired mood may lead to higher total scores.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antirheumatic Agents - therapeutic use</subject><subject>Arthritis, Rheumatoid - diagnosis</subject><subject>Arthritis, Rheumatoid - drug therapy</subject><subject>Biological and medical sciences</subject><subject>Disease activity measurement</subject><subject>Diseases of the osteoarticular system</subject><subject>Factor Analysis, Statistical</subject><subject>Female</subject><subject>Fibromyalgia</subject><subject>Fibromyalgia - diagnosis</subject><subject>Humans</subject><subject>Inflammatory joint diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pain Measurement</subject><subject>Reproducibility of Results</subject><subject>Rheumatoid arthritis</subject><subject>Severity of Illness Index</subject><issn>1462-0324</issn><issn>1460-2172</issn><issn>1462-0332</issn><issn>1460-2172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkF1LwzAUhoMobk5_gSBF0LtqPtqmwasxPyYMvXCi7CakTbpl68dMUnD_3o7WTbw6B85zHs55AThH8AZBRm7NQtWFcFVezTe3K7UgGB-APgoi7ENC8OGux0EPnFi7hBCGiMTHoIdCHGKMwj64my6Udz98w7GnS-9XqaUnjFsY7bT1RCm9TCemKjYin2vhrYXTqnT2FBxlIrfqrKsD8P74MB2N_cnr0_NoOPHTIAqcL2EWRyjBKmMKBQmVqYwZoxmWLJI0DlJBQ8YSgpiikqZUxiJhAWaEURkQgckAXLfetam-amUdL7RNVZ6LUlW15RFFCDFKG_DyH7isalM2t3HEwiiMMdvaSAulprLWqIyvjS6E2XAE-TZY_jdY3gbbbF106joplNzvdEk2wFUHCJuKPDOiTLXdcxEhFMO44fyW09ap791cmFXzB6EhH3_OOCP4Y_YyI5ySHwVnk4U</recordid><startdate>20041201</startdate><enddate>20041201</enddate><creator>Leeb, B. F.</creator><creator>Andel, I.</creator><creator>Sautner, J.</creator><creator>Nothnagl, T.</creator><creator>Rintelen, B.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20041201</creationdate><title>The DAS28 in rheumatoid arthritis and fibromyalgia patients</title><author>Leeb, B. F. ; Andel, I. ; Sautner, J. ; Nothnagl, T. ; Rintelen, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-d0f861b2ef9e14b7dcd8997f2d96d784ca7599b319e7d7c7d8ab9429397d43a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antirheumatic Agents - therapeutic use</topic><topic>Arthritis, Rheumatoid - diagnosis</topic><topic>Arthritis, Rheumatoid - drug therapy</topic><topic>Biological and medical sciences</topic><topic>Disease activity measurement</topic><topic>Diseases of the osteoarticular system</topic><topic>Factor Analysis, Statistical</topic><topic>Female</topic><topic>Fibromyalgia</topic><topic>Fibromyalgia - diagnosis</topic><topic>Humans</topic><topic>Inflammatory joint diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pain Measurement</topic><topic>Reproducibility of Results</topic><topic>Rheumatoid arthritis</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leeb, B. F.</creatorcontrib><creatorcontrib>Andel, I.</creatorcontrib><creatorcontrib>Sautner, J.</creatorcontrib><creatorcontrib>Nothnagl, T.</creatorcontrib><creatorcontrib>Rintelen, B.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leeb, B. F.</au><au>Andel, I.</au><au>Sautner, J.</au><au>Nothnagl, T.</au><au>Rintelen, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The DAS28 in rheumatoid arthritis and fibromyalgia patients</atitle><jtitle>British journal of rheumatology</jtitle><addtitle>Rheumatology</addtitle><date>2004-12-01</date><risdate>2004</risdate><volume>43</volume><issue>12</issue><spage>1504</spage><epage>1507</epage><pages>1504-1507</pages><issn>1462-0324</issn><issn>1460-2172</issn><eissn>1462-0332</eissn><eissn>1460-2172</eissn><coden>BJRHDF</coden><abstract>Objective. To compare the DAS28 (Disease Activity Score including a 28-joint count) values of rheumatoid arthritis (RA) and fibromyalgia (FM) patients, and to establish whether high pain levels and impaired mood influence DAS28 values. Methods. DAS28 values were calculated in 62 consecutive patients with RA and in 26 patients suffering from FM. Values for DAS28 scores as well as for the single items of the patient cohorts were compared using Student's t-tests. To evaluate the item weighting and internal consistency of the total score factor analysis was performed and Cronbach's alpha calculated. Results. RA patients showed a mean DAS28 score of 4.23 (±1.2; range 0.77–7.46) and in FM patients the mean DAS28 came to 4.04 (±1.13; range 1.19–6.28). DAS28 values of RA and FM patients were not significantly different statistically. Comparing the single components of the score, however, highly significant differences (P<0.0005) occurred between RA and FM patients. Cronbach's alpha for the DAS28 in RA patients amounted to 0.7329, indicating high internal consistency, whereas in FM patients it was 0.4832. Conclusion. The DAS28, as expected, proved to be inappropriate to express disease activity in FM patients. DAS28 values for expressing disease activity in RA patients may be flawed by coexisting FM and should therefore be regarded with caution as high pain levels more than impaired mood may lead to higher total scores.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>15252215</pmid><doi>10.1093/rheumatology/keh322</doi><tpages>4</tpages></addata></record> |
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| ispartof | British journal of rheumatology, 2004-12, Vol.43 (12), p.1504-1507 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Antirheumatic Agents - therapeutic use Arthritis, Rheumatoid - diagnosis Arthritis, Rheumatoid - drug therapy Biological and medical sciences Disease activity measurement Diseases of the osteoarticular system Factor Analysis, Statistical Female Fibromyalgia Fibromyalgia - diagnosis Humans Inflammatory joint diseases Male Medical sciences Middle Aged Pain Measurement Reproducibility of Results Rheumatoid arthritis Severity of Illness Index |
| title | The DAS28 in rheumatoid arthritis and fibromyalgia patients |
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