Quantitative analysis of fecal sapovirus shedding: identification of nucleotide substitutions in the capsid protein during prolonged excretion
Sapovirus (SaV) is an important pathogen causing gastroenteritis in humans. Quantitative analysis of the viral loads in feces collected from two SaV outbreaks was performed. Our results showed that SaV excretion generally decreased to an undetectable level in 2 weeks; however, some individuals excre...
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| Veröffentlicht in: | Archives of virology 2009-04, Vol.154 (4), p.689-693 |
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| creator | Iwakiri, Akira Ganmyo, Hidenari Yamamoto, Seigo Otao, Kayoko Mikasa, Mieko Kizoe, Sigeko Katayama, Kazuhiko Wakita, Takaji Takeda, Naokazu Oka, Tomoichiro |
| description | Sapovirus (SaV) is an important pathogen causing gastroenteritis in humans. Quantitative analysis of the viral loads in feces collected from two SaV outbreaks was performed. Our results showed that SaV excretion generally decreased to an undetectable level in 2 weeks; however, some individuals excrete SaV in feces at high concentrations for 2-4 weeks after the onset of illness. In addition, we identified for the first time nucleotide changes in the capsid region during prolonged excretion. |
| doi_str_mv | 10.1007/s00705-009-0358-0 |
| format | Article |
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Quantitative analysis of the viral loads in feces collected from two SaV outbreaks was performed. Our results showed that SaV excretion generally decreased to an undetectable level in 2 weeks; however, some individuals excrete SaV in feces at high concentrations for 2-4 weeks after the onset of illness. In addition, we identified for the first time nucleotide changes in the capsid region during prolonged excretion.</description><identifier>ISSN: 0304-8608</identifier><identifier>EISSN: 1432-8798</identifier><identifier>DOI: 10.1007/s00705-009-0358-0</identifier><identifier>PMID: 19301092</identifier><language>eng</language><publisher>Vienna: Vienna : Springer Vienna</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Brief Report ; Caliciviridae Infections - virology ; Capsid Proteins - genetics ; Child ; DNA polymerase ; Epidemics ; Feces ; Feces - virology ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenteritis ; Genomes ; Humans ; Illnesses ; Infectious Diseases ; Male ; Medical Microbiology ; Microbiology ; Miscellaneous ; Molecular Sequence Data ; Pathogens ; Patients ; Phylogeny ; Point Mutation ; Proteins ; Quantitative analysis ; RNA polymerase ; Sapovirus - genetics ; Sapovirus - isolation & purification ; Sequence Analysis, DNA ; Sequence Homology ; Virology ; Virus Shedding ; Young Adult</subject><ispartof>Archives of virology, 2009-04, Vol.154 (4), p.689-693</ispartof><rights>Springer-Verlag 2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-849c08e1c82b1fb27c57089eed6ca0d47ab29104e7b2aef55845a52ae46f44df3</citedby><cites>FETCH-LOGICAL-c489t-849c08e1c82b1fb27c57089eed6ca0d47ab29104e7b2aef55845a52ae46f44df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00705-009-0358-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00705-009-0358-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21367132$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19301092$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iwakiri, Akira</creatorcontrib><creatorcontrib>Ganmyo, Hidenari</creatorcontrib><creatorcontrib>Yamamoto, Seigo</creatorcontrib><creatorcontrib>Otao, Kayoko</creatorcontrib><creatorcontrib>Mikasa, Mieko</creatorcontrib><creatorcontrib>Kizoe, Sigeko</creatorcontrib><creatorcontrib>Katayama, Kazuhiko</creatorcontrib><creatorcontrib>Wakita, Takaji</creatorcontrib><creatorcontrib>Takeda, Naokazu</creatorcontrib><creatorcontrib>Oka, Tomoichiro</creatorcontrib><title>Quantitative analysis of fecal sapovirus shedding: identification of nucleotide substitutions in the capsid protein during prolonged excretion</title><title>Archives of virology</title><addtitle>Arch Virol</addtitle><addtitle>Arch Virol</addtitle><description>Sapovirus (SaV) is an important pathogen causing gastroenteritis in humans. Quantitative analysis of the viral loads in feces collected from two SaV outbreaks was performed. Our results showed that SaV excretion generally decreased to an undetectable level in 2 weeks; however, some individuals excrete SaV in feces at high concentrations for 2-4 weeks after the onset of illness. In addition, we identified for the first time nucleotide changes in the capsid region during prolonged excretion.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brief Report</subject><subject>Caliciviridae Infections - virology</subject><subject>Capsid Proteins - genetics</subject><subject>Child</subject><subject>DNA polymerase</subject><subject>Epidemics</subject><subject>Feces</subject><subject>Feces - virology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenteritis</subject><subject>Genomes</subject><subject>Humans</subject><subject>Illnesses</subject><subject>Infectious Diseases</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Molecular Sequence Data</subject><subject>Pathogens</subject><subject>Patients</subject><subject>Phylogeny</subject><subject>Point Mutation</subject><subject>Proteins</subject><subject>Quantitative analysis</subject><subject>RNA polymerase</subject><subject>Sapovirus - genetics</subject><subject>Sapovirus - isolation & purification</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Homology</subject><subject>Virology</subject><subject>Virus Shedding</subject><subject>Young Adult</subject><issn>0304-8608</issn><issn>1432-8798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kduK1EAQhhtR3HH0AbzRRtC7aPUhSWfvZPEECyK616HTqZ7tJZOMXcnivoTPbIUZXPDCmz5-_19F_UI8V_BWAdTviBcoC4CmAFO6Ah6IjbJGF65u3EOxAQO2cBW4M_GE6AaAH0z5WJypxoCCRm_E72-LH-c0-zndovSjH-4okZyijBj8IMkfptuUF5J0jX2fxt25TD2yJKbAomlc2XEJA04zf0haOmK_Zf0imUY5X6MM_kCpl4c8zchP_ZLZaL0O07jDXuKvkHFVPBWPoh8In532rbj6-OHHxefi8uunLxfvL4tgXTMXzjYBHKrgdKdip-tQ1uAaxL4KHnpb-043CizWnfYYy9LZ0pd8tFW0to9mK94cfbmHnwvS3O4TBRwGP-K0UFvVSqmqLhl89Q94My2Zx0StVtrw-I1hSB2hkCeijLE95LT3-a5V0K5JtcekWk6qXZPiZStenIyXbo_9veIUDQOvT4AnTiJmP4ZEfzmtDDdpVk4fOTqsU8V83-H_qr88iqKfWr_LbHz1XYPi2pWyZQXmDxhkt-4</recordid><startdate>20090401</startdate><enddate>20090401</enddate><creator>Iwakiri, Akira</creator><creator>Ganmyo, Hidenari</creator><creator>Yamamoto, Seigo</creator><creator>Otao, Kayoko</creator><creator>Mikasa, Mieko</creator><creator>Kizoe, Sigeko</creator><creator>Katayama, Kazuhiko</creator><creator>Wakita, Takaji</creator><creator>Takeda, Naokazu</creator><creator>Oka, Tomoichiro</creator><general>Vienna : Springer Vienna</general><general>Springer Vienna</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20090401</creationdate><title>Quantitative analysis of fecal sapovirus shedding: identification of nucleotide substitutions in the capsid protein during prolonged excretion</title><author>Iwakiri, Akira ; Ganmyo, Hidenari ; Yamamoto, Seigo ; Otao, Kayoko ; Mikasa, Mieko ; Kizoe, Sigeko ; Katayama, Kazuhiko ; Wakita, Takaji ; Takeda, Naokazu ; Oka, Tomoichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-849c08e1c82b1fb27c57089eed6ca0d47ab29104e7b2aef55845a52ae46f44df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brief Report</topic><topic>Caliciviridae Infections - virology</topic><topic>Capsid Proteins - genetics</topic><topic>Child</topic><topic>DNA polymerase</topic><topic>Epidemics</topic><topic>Feces</topic><topic>Feces - virology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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Quantitative analysis of the viral loads in feces collected from two SaV outbreaks was performed. Our results showed that SaV excretion generally decreased to an undetectable level in 2 weeks; however, some individuals excrete SaV in feces at high concentrations for 2-4 weeks after the onset of illness. In addition, we identified for the first time nucleotide changes in the capsid region during prolonged excretion.</abstract><cop>Vienna</cop><pub>Vienna : Springer Vienna</pub><pmid>19301092</pmid><doi>10.1007/s00705-009-0358-0</doi><tpages>5</tpages></addata></record> |
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| ispartof | Archives of virology, 2009-04, Vol.154 (4), p.689-693 |
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| language | eng |
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| subjects | Adolescent Adult Biological and medical sciences Biomedical and Life Sciences Biomedicine Brief Report Caliciviridae Infections - virology Capsid Proteins - genetics Child DNA polymerase Epidemics Feces Feces - virology Female Fundamental and applied biological sciences. Psychology Gastroenteritis Genomes Humans Illnesses Infectious Diseases Male Medical Microbiology Microbiology Miscellaneous Molecular Sequence Data Pathogens Patients Phylogeny Point Mutation Proteins Quantitative analysis RNA polymerase Sapovirus - genetics Sapovirus - isolation & purification Sequence Analysis, DNA Sequence Homology Virology Virus Shedding Young Adult |
| title | Quantitative analysis of fecal sapovirus shedding: identification of nucleotide substitutions in the capsid protein during prolonged excretion |
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