In vitro and in vivo SAR of pyrido[3,4- d]pyramid-4-ylamine based mGluR1 antagonists

SAR and CNS penetration of a series of novel mgluR1 antagonists is described. The multiple of the unbound K i in cerebrospinal fluid necessary to give morphine like analgesic effects in an electromyograph pinch model in rodents is given. The SAR of a series of novel pyrido[3,4- d]pyramid-4-ylamine m...

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