Thymine Dimerization in DNA Model Systems: Cyclobutane Photolesion Is Predominantly Formed via the Singlet Channel
UV-induced formation of cylcobutane pyrimidine dimers (CPD) in all thymine DNA models have been studied by femtosecond IR spectroscopy. CPDs are shown to form within ∼1 ps during the decay of the initially excited 1π π * state. The quantum yields ϕD ps determined after the 1ππ * decay equal the fina...
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| Veröffentlicht in: | Journal of the American Chemical Society 2009-04, Vol.131 (14), p.5038-5039 |
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| container_issue | 14 |
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| container_title | Journal of the American Chemical Society |
| container_volume | 131 |
| creator | Schreier, Wolfgang J Kubon, Julia Regner, Nadja Haiser, Karin Schrader, Tobias E Zinth, Wolfgang Clivio, Pascale Gilch, Peter |
| description | UV-induced formation of cylcobutane pyrimidine dimers (CPD) in all thymine DNA models have been studied by femtosecond IR spectroscopy. CPDs are shown to form within ∼1 ps during the decay of the initially excited 1π π * state. The quantum yields ϕD ps determined after the 1ππ * decay equal the final yield ϕD cw. This gives evidence for a predominance of the singlet channel in CPD formation. |
| doi_str_mv | 10.1021/ja900436t |
| format | Article |
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CPDs are shown to form within ∼1 ps during the decay of the initially excited 1π π * state. The quantum yields ϕD ps determined after the 1ππ * decay equal the final yield ϕD cw. This gives evidence for a predominance of the singlet channel in CPD formation.</description><identifier>ISSN: 0002-7863</identifier><identifier>EISSN: 1520-5126</identifier><identifier>DOI: 10.1021/ja900436t</identifier><identifier>PMID: 19309140</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>DNA - chemistry ; DNA - metabolism ; Models, Molecular ; Nucleic Acid Conformation ; Pyrimidine Dimers - chemistry ; Pyrimidine Dimers - metabolism ; Spectrophotometry, Infrared ; Thymine - chemistry ; Thymine - metabolism ; Time Factors ; Ultraviolet Rays</subject><ispartof>Journal of the American Chemical Society, 2009-04, Vol.131 (14), p.5038-5039</ispartof><rights>Copyright © 2009 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a313t-6d15bfd4264adbc9f1b3cbcdd9eb526e0e62ddb69260e51a2d5ee4bed15cb6be3</citedby><cites>FETCH-LOGICAL-a313t-6d15bfd4264adbc9f1b3cbcdd9eb526e0e62ddb69260e51a2d5ee4bed15cb6be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/ja900436t$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/ja900436t$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19309140$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schreier, Wolfgang J</creatorcontrib><creatorcontrib>Kubon, Julia</creatorcontrib><creatorcontrib>Regner, Nadja</creatorcontrib><creatorcontrib>Haiser, Karin</creatorcontrib><creatorcontrib>Schrader, Tobias E</creatorcontrib><creatorcontrib>Zinth, Wolfgang</creatorcontrib><creatorcontrib>Clivio, Pascale</creatorcontrib><creatorcontrib>Gilch, Peter</creatorcontrib><title>Thymine Dimerization in DNA Model Systems: Cyclobutane Photolesion Is Predominantly Formed via the Singlet Channel</title><title>Journal of the American Chemical Society</title><addtitle>J. Am. Chem. Soc</addtitle><description>UV-induced formation of cylcobutane pyrimidine dimers (CPD) in all thymine DNA models have been studied by femtosecond IR spectroscopy. CPDs are shown to form within ∼1 ps during the decay of the initially excited 1π π * state. The quantum yields ϕD ps determined after the 1ππ * decay equal the final yield ϕD cw. This gives evidence for a predominance of the singlet channel in CPD formation.</description><subject>DNA - chemistry</subject><subject>DNA - metabolism</subject><subject>Models, Molecular</subject><subject>Nucleic Acid Conformation</subject><subject>Pyrimidine Dimers - chemistry</subject><subject>Pyrimidine Dimers - metabolism</subject><subject>Spectrophotometry, Infrared</subject><subject>Thymine - chemistry</subject><subject>Thymine - metabolism</subject><subject>Time Factors</subject><subject>Ultraviolet Rays</subject><issn>0002-7863</issn><issn>1520-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1LAzEQhoMotlYP_gHJRcHDapLdTbveSrVa8Aus5yXZTG1KdlOTrLD-elNa9OJpGHjmYd4XoVNKrihh9HolCkKylIc91Kc5I0lOGd9HfUIIS4YjnvbQkferuGZsRA9RjxYpKWhG-sjNl12tG8C3uganv0XQtsG6wbfPY_xkFRj81vkAtb_Bk64yVrZBRPx1aYM14Df0zONXB8pGj2iC6fDUuhoU_tIChyXgN918GAh4shRNA-YYHSyE8XCymwP0Pr2bTx6Sx5f72WT8mIiUpiHhiuZyoTLGM6FkVSyoTCtZKVWAzBkHApwpJXnBOIGcCqZygExCPKskl5AO0MXWu3b2swUfylr7CoyJ_9vWl3xISTFK8whebsHKWe8dLMq107VwXUlJuSm4_C04smc7aStjxj9y12gEzreAqHy5sq1rYsZ_RD_llYRW</recordid><startdate>20090415</startdate><enddate>20090415</enddate><creator>Schreier, Wolfgang J</creator><creator>Kubon, Julia</creator><creator>Regner, Nadja</creator><creator>Haiser, Karin</creator><creator>Schrader, Tobias E</creator><creator>Zinth, Wolfgang</creator><creator>Clivio, Pascale</creator><creator>Gilch, Peter</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090415</creationdate><title>Thymine Dimerization in DNA Model Systems: Cyclobutane Photolesion Is Predominantly Formed via the Singlet Channel</title><author>Schreier, Wolfgang J ; Kubon, Julia ; Regner, Nadja ; Haiser, Karin ; Schrader, Tobias E ; Zinth, Wolfgang ; Clivio, Pascale ; Gilch, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a313t-6d15bfd4264adbc9f1b3cbcdd9eb526e0e62ddb69260e51a2d5ee4bed15cb6be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>DNA - chemistry</topic><topic>DNA - metabolism</topic><topic>Models, Molecular</topic><topic>Nucleic Acid Conformation</topic><topic>Pyrimidine Dimers - chemistry</topic><topic>Pyrimidine Dimers - metabolism</topic><topic>Spectrophotometry, Infrared</topic><topic>Thymine - chemistry</topic><topic>Thymine - metabolism</topic><topic>Time Factors</topic><topic>Ultraviolet Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schreier, Wolfgang J</creatorcontrib><creatorcontrib>Kubon, Julia</creatorcontrib><creatorcontrib>Regner, Nadja</creatorcontrib><creatorcontrib>Haiser, Karin</creatorcontrib><creatorcontrib>Schrader, Tobias E</creatorcontrib><creatorcontrib>Zinth, Wolfgang</creatorcontrib><creatorcontrib>Clivio, Pascale</creatorcontrib><creatorcontrib>Gilch, Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Chemical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schreier, Wolfgang J</au><au>Kubon, Julia</au><au>Regner, Nadja</au><au>Haiser, Karin</au><au>Schrader, Tobias E</au><au>Zinth, Wolfgang</au><au>Clivio, Pascale</au><au>Gilch, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thymine Dimerization in DNA Model Systems: Cyclobutane Photolesion Is Predominantly Formed via the Singlet Channel</atitle><jtitle>Journal of the American Chemical Society</jtitle><addtitle>J. Am. Chem. Soc</addtitle><date>2009-04-15</date><risdate>2009</risdate><volume>131</volume><issue>14</issue><spage>5038</spage><epage>5039</epage><pages>5038-5039</pages><issn>0002-7863</issn><eissn>1520-5126</eissn><abstract>UV-induced formation of cylcobutane pyrimidine dimers (CPD) in all thymine DNA models have been studied by femtosecond IR spectroscopy. CPDs are shown to form within ∼1 ps during the decay of the initially excited 1π π * state. The quantum yields ϕD ps determined after the 1ππ * decay equal the final yield ϕD cw. This gives evidence for a predominance of the singlet channel in CPD formation.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>19309140</pmid><doi>10.1021/ja900436t</doi><tpages>2</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; American Chemical Society (ACS) Journals |
| subjects | DNA - chemistry DNA - metabolism Models, Molecular Nucleic Acid Conformation Pyrimidine Dimers - chemistry Pyrimidine Dimers - metabolism Spectrophotometry, Infrared Thymine - chemistry Thymine - metabolism Time Factors Ultraviolet Rays |
| title | Thymine Dimerization in DNA Model Systems: Cyclobutane Photolesion Is Predominantly Formed via the Singlet Channel |
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