Clinical Application of Bone Marrow Implantation in Patients With Arteriosclerosis Obliterans, and the Association Between Efficacy and the Number of Implanted Bone Marrow Cells
Background There have been a number of recent reports on the use of autologous bone marrow implantation (BMI) in the treatment of peripheral arterial disease, with a clinical response rate of approximately 70%. However, the factors that influence efficacy have not yet been clarified. We have analyze...
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| Veröffentlicht in: | Circulation Journal 2004, Vol.68(12), pp.1189-1193 |
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| creator | Saigawa, Takashi Kato, Kiminori Ozawa, Takuya Toba, Ken Makiyama, Yashiro Minagawa, Shiro Hashimoto, Shigeo Furukawa, Tatsuo Nakamura, Yuichi Hanawa, Haruo Kodama, Makoto Yoshimura, Nobuhiko Fujiwara, Hiroshi Namura, Osamu Sogawa, Masakazu Hayashi, Jun-ichi Aizawa, Yoshifusa |
| description | Background There have been a number of recent reports on the use of autologous bone marrow implantation (BMI) in the treatment of peripheral arterial disease, with a clinical response rate of approximately 70%. However, the factors that influence efficacy have not yet been clarified. We have analyzed the relationship between the number of implanted bone marrow cells and the clinical efficacy of BMI. Methods and Results Eight patients with arteriosclerosis obliterans were treated with BMI. Bone marrow was aspirated from the ilium (500-1,000 ml), the mononuclear cells were separated and then were implanted. The clinical effectiveness of BMI was evaluated by assessing changes in the ankle-brachial pressure index (ABI) and the transcutaneous oxygen pressure (TcO2) between the pre-treatment baseline, with follow-up testing at 4 weeks. These changes were defined as ΔABI and ΔTcO 2. The mean number of CD34-positive cells was 1.04±0.60 ×106 /kg body weight. There was a strong correlation between the number of CD34-positive cells and ΔABI (r=0.754, p=0.028). Conclusions It is likely that the number of implanted CD34-positive cells is one of the primary factors that influence the clinical efficacy of BMI. (Circ J 2004; 68: 1189 - 1193) |
| doi_str_mv | 10.1253/circj.68.1189 |
| format | Article |
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However, the factors that influence efficacy have not yet been clarified. We have analyzed the relationship between the number of implanted bone marrow cells and the clinical efficacy of BMI. Methods and Results Eight patients with arteriosclerosis obliterans were treated with BMI. Bone marrow was aspirated from the ilium (500-1,000 ml), the mononuclear cells were separated and then were implanted. The clinical effectiveness of BMI was evaluated by assessing changes in the ankle-brachial pressure index (ABI) and the transcutaneous oxygen pressure (TcO2) between the pre-treatment baseline, with follow-up testing at 4 weeks. These changes were defined as ΔABI and ΔTcO 2. The mean number of CD34-positive cells was 1.04±0.60 ×106 /kg body weight. There was a strong correlation between the number of CD34-positive cells and ΔABI (r=0.754, p=0.028). Conclusions It is likely that the number of implanted CD34-positive cells is one of the primary factors that influence the clinical efficacy of BMI. (Circ J 2004; 68: 1189 - 1193)</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.68.1189</identifier><identifier>PMID: 15564705</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Aged ; Angiogenesis ; Angiography, Digital Subtraction ; Ankle - blood supply ; Antigens, CD34 - analysis ; Arteriosclerosis obliterans ; Arteriosclerosis Obliterans - blood ; Arteriosclerosis Obliterans - diagnostic imaging ; Arteriosclerosis Obliterans - physiopathology ; Arteriosclerosis Obliterans - surgery ; Blood Gas Monitoring, Transcutaneous ; Blood Pressure ; Bone Marrow Cells - immunology ; Bone marrow implantation ; Bone Marrow Transplantation ; Brachial Artery - physiopathology ; CD34-positive cells ; Cell Count ; Collateral Circulation ; Female ; Humans ; Leg - blood supply ; Male ; Middle Aged ; Mononuclear cells ; Neovascularization, Physiologic ; Treatment Outcome ; Ultrasonography</subject><ispartof>Circulation Journal, 2004, Vol.68(12), pp.1189-1193</ispartof><rights>2004 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-6d5742641182548a6ae6a5d8430727aaa48763c6506d4698bb87de18529306d93</citedby><cites>FETCH-LOGICAL-c481t-6d5742641182548a6ae6a5d8430727aaa48763c6506d4698bb87de18529306d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15564705$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saigawa, Takashi</creatorcontrib><creatorcontrib>Kato, Kiminori</creatorcontrib><creatorcontrib>Ozawa, Takuya</creatorcontrib><creatorcontrib>Toba, Ken</creatorcontrib><creatorcontrib>Makiyama, Yashiro</creatorcontrib><creatorcontrib>Minagawa, Shiro</creatorcontrib><creatorcontrib>Hashimoto, Shigeo</creatorcontrib><creatorcontrib>Furukawa, Tatsuo</creatorcontrib><creatorcontrib>Nakamura, Yuichi</creatorcontrib><creatorcontrib>Hanawa, Haruo</creatorcontrib><creatorcontrib>Kodama, Makoto</creatorcontrib><creatorcontrib>Yoshimura, Nobuhiko</creatorcontrib><creatorcontrib>Fujiwara, Hiroshi</creatorcontrib><creatorcontrib>Namura, Osamu</creatorcontrib><creatorcontrib>Sogawa, Masakazu</creatorcontrib><creatorcontrib>Hayashi, Jun-ichi</creatorcontrib><creatorcontrib>Aizawa, Yoshifusa</creatorcontrib><title>Clinical Application of Bone Marrow Implantation in Patients With Arteriosclerosis Obliterans, and the Association Between Efficacy and the Number of Implanted Bone Marrow Cells</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background There have been a number of recent reports on the use of autologous bone marrow implantation (BMI) in the treatment of peripheral arterial disease, with a clinical response rate of approximately 70%. However, the factors that influence efficacy have not yet been clarified. We have analyzed the relationship between the number of implanted bone marrow cells and the clinical efficacy of BMI. Methods and Results Eight patients with arteriosclerosis obliterans were treated with BMI. Bone marrow was aspirated from the ilium (500-1,000 ml), the mononuclear cells were separated and then were implanted. The clinical effectiveness of BMI was evaluated by assessing changes in the ankle-brachial pressure index (ABI) and the transcutaneous oxygen pressure (TcO2) between the pre-treatment baseline, with follow-up testing at 4 weeks. These changes were defined as ΔABI and ΔTcO 2. The mean number of CD34-positive cells was 1.04±0.60 ×106 /kg body weight. There was a strong correlation between the number of CD34-positive cells and ΔABI (r=0.754, p=0.028). Conclusions It is likely that the number of implanted CD34-positive cells is one of the primary factors that influence the clinical efficacy of BMI. (Circ J 2004; 68: 1189 - 1193)</description><subject>Aged</subject><subject>Angiogenesis</subject><subject>Angiography, Digital Subtraction</subject><subject>Ankle - blood supply</subject><subject>Antigens, CD34 - analysis</subject><subject>Arteriosclerosis obliterans</subject><subject>Arteriosclerosis Obliterans - blood</subject><subject>Arteriosclerosis Obliterans - diagnostic imaging</subject><subject>Arteriosclerosis Obliterans - physiopathology</subject><subject>Arteriosclerosis Obliterans - surgery</subject><subject>Blood Gas Monitoring, Transcutaneous</subject><subject>Blood Pressure</subject><subject>Bone Marrow Cells - immunology</subject><subject>Bone marrow implantation</subject><subject>Bone Marrow Transplantation</subject><subject>Brachial Artery - physiopathology</subject><subject>CD34-positive cells</subject><subject>Cell Count</subject><subject>Collateral Circulation</subject><subject>Female</subject><subject>Humans</subject><subject>Leg - blood supply</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mononuclear cells</subject><subject>Neovascularization, Physiologic</subject><subject>Treatment Outcome</subject><subject>Ultrasonography</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1v1DAQhiMEoqVw5Ip84kQW27Ed57hdSlupUA5UPVqOM2G9cpxge1X1Z_Uf1ttELVzs0cyjdz7eovhI8IpQXn01NpjdSsgVIbJ5VRyTitUlkxS_fopF2UhWHRXvYtxhTBvMm7fFEeFcsBrz4-Jh46y3Rju0niaXg2RHj8YenY4e0A8dwniHLofJaZ_mmvXoV47Ap4hubdqidUgQ7BiNgzBGG9F162xOaR-_IO07lLaA1jGOxs4Kp5DuADw66_vc0Nw_Qz_3Qwvh0H3pCN1_c2zAufi-eNNrF-HD8p8UN9_Pfm8uyqvr88vN-qo0TJJUio7XjAqWz0I5k1poEJp3-Ri4prXWmslaVEZwLDomGtm2su6ASE6bKqea6qT4POtOYfy7h5jUYKPJE2gP4z4qURPc0EpmsJxBk9ePAXo1BTvocK8IVgeP1JNHSkh18CjznxbhfTtA90IvpmTg2wzsYtJ_4BnQIdl85H_k6PIedF_KWx0U-OoR_oaoFw</recordid><startdate>20041201</startdate><enddate>20041201</enddate><creator>Saigawa, Takashi</creator><creator>Kato, Kiminori</creator><creator>Ozawa, Takuya</creator><creator>Toba, Ken</creator><creator>Makiyama, Yashiro</creator><creator>Minagawa, Shiro</creator><creator>Hashimoto, Shigeo</creator><creator>Furukawa, Tatsuo</creator><creator>Nakamura, Yuichi</creator><creator>Hanawa, Haruo</creator><creator>Kodama, Makoto</creator><creator>Yoshimura, Nobuhiko</creator><creator>Fujiwara, Hiroshi</creator><creator>Namura, Osamu</creator><creator>Sogawa, Masakazu</creator><creator>Hayashi, Jun-ichi</creator><creator>Aizawa, Yoshifusa</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041201</creationdate><title>Clinical Application of Bone Marrow Implantation in Patients With Arteriosclerosis Obliterans, and the Association Between Efficacy and the Number of Implanted Bone Marrow Cells</title><author>Saigawa, Takashi ; Kato, Kiminori ; Ozawa, Takuya ; Toba, Ken ; Makiyama, Yashiro ; Minagawa, Shiro ; Hashimoto, Shigeo ; Furukawa, Tatsuo ; Nakamura, Yuichi ; Hanawa, Haruo ; Kodama, Makoto ; Yoshimura, Nobuhiko ; Fujiwara, Hiroshi ; Namura, Osamu ; Sogawa, Masakazu ; Hayashi, Jun-ichi ; Aizawa, Yoshifusa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-6d5742641182548a6ae6a5d8430727aaa48763c6506d4698bb87de18529306d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aged</topic><topic>Angiogenesis</topic><topic>Angiography, Digital Subtraction</topic><topic>Ankle - blood supply</topic><topic>Antigens, CD34 - analysis</topic><topic>Arteriosclerosis obliterans</topic><topic>Arteriosclerosis Obliterans - blood</topic><topic>Arteriosclerosis Obliterans - diagnostic imaging</topic><topic>Arteriosclerosis Obliterans - physiopathology</topic><topic>Arteriosclerosis Obliterans - surgery</topic><topic>Blood Gas Monitoring, Transcutaneous</topic><topic>Blood Pressure</topic><topic>Bone Marrow Cells - immunology</topic><topic>Bone marrow implantation</topic><topic>Bone Marrow Transplantation</topic><topic>Brachial Artery - physiopathology</topic><topic>CD34-positive cells</topic><topic>Cell Count</topic><topic>Collateral Circulation</topic><topic>Female</topic><topic>Humans</topic><topic>Leg - blood supply</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mononuclear cells</topic><topic>Neovascularization, Physiologic</topic><topic>Treatment Outcome</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saigawa, Takashi</creatorcontrib><creatorcontrib>Kato, Kiminori</creatorcontrib><creatorcontrib>Ozawa, Takuya</creatorcontrib><creatorcontrib>Toba, Ken</creatorcontrib><creatorcontrib>Makiyama, Yashiro</creatorcontrib><creatorcontrib>Minagawa, Shiro</creatorcontrib><creatorcontrib>Hashimoto, Shigeo</creatorcontrib><creatorcontrib>Furukawa, Tatsuo</creatorcontrib><creatorcontrib>Nakamura, Yuichi</creatorcontrib><creatorcontrib>Hanawa, Haruo</creatorcontrib><creatorcontrib>Kodama, Makoto</creatorcontrib><creatorcontrib>Yoshimura, Nobuhiko</creatorcontrib><creatorcontrib>Fujiwara, Hiroshi</creatorcontrib><creatorcontrib>Namura, Osamu</creatorcontrib><creatorcontrib>Sogawa, Masakazu</creatorcontrib><creatorcontrib>Hayashi, Jun-ichi</creatorcontrib><creatorcontrib>Aizawa, Yoshifusa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saigawa, Takashi</au><au>Kato, Kiminori</au><au>Ozawa, Takuya</au><au>Toba, Ken</au><au>Makiyama, Yashiro</au><au>Minagawa, Shiro</au><au>Hashimoto, Shigeo</au><au>Furukawa, Tatsuo</au><au>Nakamura, Yuichi</au><au>Hanawa, Haruo</au><au>Kodama, Makoto</au><au>Yoshimura, Nobuhiko</au><au>Fujiwara, Hiroshi</au><au>Namura, Osamu</au><au>Sogawa, Masakazu</au><au>Hayashi, Jun-ichi</au><au>Aizawa, Yoshifusa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Application of Bone Marrow Implantation in Patients With Arteriosclerosis Obliterans, and the Association Between Efficacy and the Number of Implanted Bone Marrow Cells</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2004-12-01</date><risdate>2004</risdate><volume>68</volume><issue>12</issue><spage>1189</spage><epage>1193</epage><pages>1189-1193</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Background There have been a number of recent reports on the use of autologous bone marrow implantation (BMI) in the treatment of peripheral arterial disease, with a clinical response rate of approximately 70%. However, the factors that influence efficacy have not yet been clarified. We have analyzed the relationship between the number of implanted bone marrow cells and the clinical efficacy of BMI. Methods and Results Eight patients with arteriosclerosis obliterans were treated with BMI. Bone marrow was aspirated from the ilium (500-1,000 ml), the mononuclear cells were separated and then were implanted. The clinical effectiveness of BMI was evaluated by assessing changes in the ankle-brachial pressure index (ABI) and the transcutaneous oxygen pressure (TcO2) between the pre-treatment baseline, with follow-up testing at 4 weeks. These changes were defined as ΔABI and ΔTcO 2. The mean number of CD34-positive cells was 1.04±0.60 ×106 /kg body weight. There was a strong correlation between the number of CD34-positive cells and ΔABI (r=0.754, p=0.028). Conclusions It is likely that the number of implanted CD34-positive cells is one of the primary factors that influence the clinical efficacy of BMI. (Circ J 2004; 68: 1189 - 1193)</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>15564705</pmid><doi>10.1253/circj.68.1189</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Angiogenesis Angiography, Digital Subtraction Ankle - blood supply Antigens, CD34 - analysis Arteriosclerosis obliterans Arteriosclerosis Obliterans - blood Arteriosclerosis Obliterans - diagnostic imaging Arteriosclerosis Obliterans - physiopathology Arteriosclerosis Obliterans - surgery Blood Gas Monitoring, Transcutaneous Blood Pressure Bone Marrow Cells - immunology Bone marrow implantation Bone Marrow Transplantation Brachial Artery - physiopathology CD34-positive cells Cell Count Collateral Circulation Female Humans Leg - blood supply Male Middle Aged Mononuclear cells Neovascularization, Physiologic Treatment Outcome Ultrasonography |
| title | Clinical Application of Bone Marrow Implantation in Patients With Arteriosclerosis Obliterans, and the Association Between Efficacy and the Number of Implanted Bone Marrow Cells |
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