Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: Implications for cell-based transplantation therapy

Because mesenchymal stem cells can differentiate into chondrocyte-like cells, we ask the question, can mesenchymal stem cells commit to the nucleus pulposus phenotype? Back pain, a significant source of morbidity in our society, is linked to degenerative changes of the intervertebral disc. Absence o...

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Veröffentlicht in:	Spine (Philadelphia, Pa. 1976) Pa. 1976), 2004-12, Vol.29 (23), p.2627-2632
Hauptverfasser:	RISBUD, Makarand V, ALBERT, Todd J, GUTTAPALLI, Asha, VRESILOVIC, Edward J, HILLIBRAND, Alan S, VACCARO, Alexander R, SHAPIRO, Irving M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biomarkers - metabolism Cell Differentiation - physiology Cell Hypoxia - physiology Cell Survival Cells, Cultured Cerebrospinal fluid. Meninges. Spinal cord Development. Senescence. Regeneration. Transplantation Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Fundamental and applied biological sciences. Psychology Glycosaminoglycans - metabolism Intervertebral Disc - cytology Intervertebral Disc - metabolism Isolated neuron and nerve. Neuroglia MAP Kinase Signaling System - physiology Medical sciences Mesenchymal Stem Cell Transplantation Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Nervous system (semeiology, syndromes) Neurology Phenotype Rats Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Transforming Growth Factor beta - pharmacology Up-Regulation Vertebrates: nervous system and sense organs
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