Dermal scatter reduction in human skin: A method using controlled application of glycerol
Background and Objective Previous studies in a hairless Guinea pig model showed that transdermal application of glycerol effected a temporary reduction in dermal scatter of light. This study focuses on the application of this protocol on human patients. Study Design/Materials and Methods After strat...
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| Veröffentlicht in: | Lasers in surgery and medicine 2009-04, Vol.41 (4), p.251-255 |
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| container_title | Lasers in surgery and medicine |
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| creator | Fox, Matthew A. Diven, Dayna G. Sra, Karen Boretsky, Adam Poonawalla, Tasneem Readinger, Allison Motamedi, Massoud McNichols, Roger J. |
| description | Background and Objective
Previous studies in a hairless Guinea pig model showed that transdermal application of glycerol effected a temporary reduction in dermal scatter of light. This study focuses on the application of this protocol on human patients.
Study Design/Materials and Methods
After stratum corneal removal, glycerol was applied to human subjects using a low pressure transdermal application device. Optical coherence tomography imaging showed increased intensity of radiation reaching deeper regions in the skin and photographs showed enhanced visualization of dermal structures.
Results/Conclusion
Topically applied glycerol increased light penetration of in vivo corneal‐stripped skin. This minimally invasive approach to temporary dermal scatter reduction has the potential to improve the efficacy of light‐based diagnostic or therapeutic devices. Lasers Surg. Med. 41:251–255, 2009. © 2009 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/lsm.20767 |
| format | Article |
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Previous studies in a hairless Guinea pig model showed that transdermal application of glycerol effected a temporary reduction in dermal scatter of light. This study focuses on the application of this protocol on human patients.
Study Design/Materials and Methods
After stratum corneal removal, glycerol was applied to human subjects using a low pressure transdermal application device. Optical coherence tomography imaging showed increased intensity of radiation reaching deeper regions in the skin and photographs showed enhanced visualization of dermal structures.
Results/Conclusion
Topically applied glycerol increased light penetration of in vivo corneal‐stripped skin. This minimally invasive approach to temporary dermal scatter reduction has the potential to improve the efficacy of light‐based diagnostic or therapeutic devices. Lasers Surg. Med. 41:251–255, 2009. © 2009 Wiley‐Liss, Inc.</description><identifier>ISSN: 0196-8092</identifier><identifier>EISSN: 1096-9101</identifier><identifier>DOI: 10.1002/lsm.20767</identifier><identifier>PMID: 19347945</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Administration, Cutaneous ; dermal scatter reduction ; glycerol ; Glycerol - administration & dosage ; Humans ; Low-Level Light Therapy - methods ; optical clearing ; skin ; Skin - drug effects ; Skin - radiation effects ; tattoo removal ; Tattooing ; Tomography, Optical Coherence ; transdermal</subject><ispartof>Lasers in surgery and medicine, 2009-04, Vol.41 (4), p.251-255</ispartof><rights>Copyright © 2009 Wiley‐Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3927-96bb51cf1f07203f35aa93c4e875e242ac9f3ffe8c0011fd70cfe5804b58e9813</citedby><cites>FETCH-LOGICAL-c3927-96bb51cf1f07203f35aa93c4e875e242ac9f3ffe8c0011fd70cfe5804b58e9813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flsm.20767$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flsm.20767$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19347945$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fox, Matthew A.</creatorcontrib><creatorcontrib>Diven, Dayna G.</creatorcontrib><creatorcontrib>Sra, Karen</creatorcontrib><creatorcontrib>Boretsky, Adam</creatorcontrib><creatorcontrib>Poonawalla, Tasneem</creatorcontrib><creatorcontrib>Readinger, Allison</creatorcontrib><creatorcontrib>Motamedi, Massoud</creatorcontrib><creatorcontrib>McNichols, Roger J.</creatorcontrib><title>Dermal scatter reduction in human skin: A method using controlled application of glycerol</title><title>Lasers in surgery and medicine</title><addtitle>Lasers Surg. Med</addtitle><description>Background and Objective
Previous studies in a hairless Guinea pig model showed that transdermal application of glycerol effected a temporary reduction in dermal scatter of light. This study focuses on the application of this protocol on human patients.
Study Design/Materials and Methods
After stratum corneal removal, glycerol was applied to human subjects using a low pressure transdermal application device. Optical coherence tomography imaging showed increased intensity of radiation reaching deeper regions in the skin and photographs showed enhanced visualization of dermal structures.
Results/Conclusion
Topically applied glycerol increased light penetration of in vivo corneal‐stripped skin. This minimally invasive approach to temporary dermal scatter reduction has the potential to improve the efficacy of light‐based diagnostic or therapeutic devices. Lasers Surg. Med. 41:251–255, 2009. © 2009 Wiley‐Liss, Inc.</description><subject>Administration, Cutaneous</subject><subject>dermal scatter reduction</subject><subject>glycerol</subject><subject>Glycerol - administration & dosage</subject><subject>Humans</subject><subject>Low-Level Light Therapy - methods</subject><subject>optical clearing</subject><subject>skin</subject><subject>Skin - drug effects</subject><subject>Skin - radiation effects</subject><subject>tattoo removal</subject><subject>Tattooing</subject><subject>Tomography, Optical Coherence</subject><subject>transdermal</subject><issn>0196-8092</issn><issn>1096-9101</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhi1UBFvKgT9Q-VSJQ2Acx3HMDVEKSLvtgX6Ik-V1xmBwkq2dqN1_X9Nd2lPV04w0z_tK8xByxOCEAZSnIXUnJcha7pAZA1UXigF7RWbA8t6AKvfJ65QeAYBnbI_sM8UrqSoxI3fvMXYm0GTNOGKkEdvJjn7oqe_pw9SZnqYn35_Rc9rh-DC0dEq-v6d26Mc4hIAtNatV8Dn-HBocvQ9ri_n0huw6ExIebucB-fLh8vPFdTH_dHVzcT4vLFelLFS9XApmHXMgS-COC2MUtxU2UmBZlcYqx53DxgIw5loJ1qFooFqKBlXD-AF5t-ldxeH7hGnUnU8WQzA9DlPStWTQyFr9FyxBCA4gMni8AW0cUoro9Cr6zsS1ZqCfhessXP8Wntm329Jp2WH7l9wazsDpBvjhA67_3aTnt4uXymKT8GnEn38SJj7lX7gU-tvHK70APr-uv97qBf8FD1-ZwA</recordid><startdate>200904</startdate><enddate>200904</enddate><creator>Fox, Matthew A.</creator><creator>Diven, Dayna G.</creator><creator>Sra, Karen</creator><creator>Boretsky, Adam</creator><creator>Poonawalla, Tasneem</creator><creator>Readinger, Allison</creator><creator>Motamedi, Massoud</creator><creator>McNichols, Roger J.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200904</creationdate><title>Dermal scatter reduction in human skin: A method using controlled application of glycerol</title><author>Fox, Matthew A. ; Diven, Dayna G. ; Sra, Karen ; Boretsky, Adam ; Poonawalla, Tasneem ; Readinger, Allison ; Motamedi, Massoud ; McNichols, Roger J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3927-96bb51cf1f07203f35aa93c4e875e242ac9f3ffe8c0011fd70cfe5804b58e9813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Administration, Cutaneous</topic><topic>dermal scatter reduction</topic><topic>glycerol</topic><topic>Glycerol - administration & dosage</topic><topic>Humans</topic><topic>Low-Level Light Therapy - methods</topic><topic>optical clearing</topic><topic>skin</topic><topic>Skin - drug effects</topic><topic>Skin - radiation effects</topic><topic>tattoo removal</topic><topic>Tattooing</topic><topic>Tomography, Optical Coherence</topic><topic>transdermal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fox, Matthew A.</creatorcontrib><creatorcontrib>Diven, Dayna G.</creatorcontrib><creatorcontrib>Sra, Karen</creatorcontrib><creatorcontrib>Boretsky, Adam</creatorcontrib><creatorcontrib>Poonawalla, Tasneem</creatorcontrib><creatorcontrib>Readinger, Allison</creatorcontrib><creatorcontrib>Motamedi, Massoud</creatorcontrib><creatorcontrib>McNichols, Roger J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Lasers in surgery and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fox, Matthew A.</au><au>Diven, Dayna G.</au><au>Sra, Karen</au><au>Boretsky, Adam</au><au>Poonawalla, Tasneem</au><au>Readinger, Allison</au><au>Motamedi, Massoud</au><au>McNichols, Roger J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dermal scatter reduction in human skin: A method using controlled application of glycerol</atitle><jtitle>Lasers in surgery and medicine</jtitle><addtitle>Lasers Surg. Med</addtitle><date>2009-04</date><risdate>2009</risdate><volume>41</volume><issue>4</issue><spage>251</spage><epage>255</epage><pages>251-255</pages><issn>0196-8092</issn><eissn>1096-9101</eissn><abstract>Background and Objective
Previous studies in a hairless Guinea pig model showed that transdermal application of glycerol effected a temporary reduction in dermal scatter of light. This study focuses on the application of this protocol on human patients.
Study Design/Materials and Methods
After stratum corneal removal, glycerol was applied to human subjects using a low pressure transdermal application device. Optical coherence tomography imaging showed increased intensity of radiation reaching deeper regions in the skin and photographs showed enhanced visualization of dermal structures.
Results/Conclusion
Topically applied glycerol increased light penetration of in vivo corneal‐stripped skin. This minimally invasive approach to temporary dermal scatter reduction has the potential to improve the efficacy of light‐based diagnostic or therapeutic devices. Lasers Surg. Med. 41:251–255, 2009. © 2009 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>19347945</pmid><doi>10.1002/lsm.20767</doi><tpages>5</tpages></addata></record> |
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| ispartof | Lasers in surgery and medicine, 2009-04, Vol.41 (4), p.251-255 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Administration, Cutaneous dermal scatter reduction glycerol Glycerol - administration & dosage Humans Low-Level Light Therapy - methods optical clearing skin Skin - drug effects Skin - radiation effects tattoo removal Tattooing Tomography, Optical Coherence transdermal |
| title | Dermal scatter reduction in human skin: A method using controlled application of glycerol |
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