Retrovirus budding
The release of retrovirus particles from the infected cell is greatly stimulated by short motifs, known as “late” or “L” domains, present within the Gag precursor protein. Three distinct classes of L domains have been identified; these bear the core sequence: Pro-Thr/Ser-Ala-Pro [P(T/S)AP], Pro-Pro-...
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| Veröffentlicht in: | Virus research 2004-12, Vol.106 (2), p.87-102 |
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| container_title | Virus research |
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| creator | Demirov, Dimiter G. Freed, Eric O. |
| description | The release of retrovirus particles from the infected cell is greatly stimulated by short motifs, known as “late” or “L” domains, present within the Gag precursor protein. Three distinct classes of L domains have been identified; these bear the core sequence: Pro-Thr/Ser-Ala-Pro [P(T/S)AP], Pro-Pro-x-Tyr (PPxY), or Tyr-Pro-x-Leu (YPxL). A number of recent studies have demonstrated that L domains function by interacting with components of the machinery responsible for sorting cellular proteins into the multivesicular body (MVB) pathway. This review traces the history of L domain discovery and characterization, and highlights the relationship between L domain activity, retrovirus release, and the host endosomal sorting machinery. |
| doi_str_mv | 10.1016/j.virusres.2004.08.007 |
| format | Article |
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| ispartof | Virus research, 2004-12, Vol.106 (2), p.87-102 |
| issn | 0168-1702 1872-7492 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Gene Expression Regulation, Viral Gene Products, gag - chemistry Gene Products, gag - genetics Gene Products, gag - metabolism Gene Products, gag - physiology L domains Multivesicular Retroviridae - chemistry Retroviridae - genetics Retroviridae - growth & development Retroviridae - physiology Retrovirus Ubiquitin - metabolism Virus Assembly - physiology |
| title | Retrovirus budding |
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