GDF11 modulates NGN3+ islet progenitor cell number and promotes beta-cell differentiation in pancreas development

Identification of endogenous signals that regulate expansion and maturation of organ-specific progenitor cells is a major goal in studies of organ development. Here we provide evidence that growth differentiation factor 11 (GDF11), a member of the TGF-beta ligand family, governs the number and matur...

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Veröffentlicht in:	Development (Cambridge) 2004-12, Vol.131 (24), p.6163-6174
Hauptverfasser:	Harmon, Erin B, Apelqvist, Asa A, Smart, Nora G, Gu, Xueying, Osborne, Douglas H, Kim, Seung K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors Bone Morphogenetic Proteins - metabolism Cell Differentiation - physiology Cell Proliferation DNA-Binding Proteins - metabolism Embryo, Mammalian - cytology Embryo, Mammalian - metabolism Gene Expression Regulation, Developmental - physiology Growth Differentiation Factors Islets of Langerhans - cytology Islets of Langerhans - embryology Islets of Langerhans - metabolism Membrane Proteins - metabolism Mice Mice, Knockout Nerve Tissue Proteins - metabolism Pancreas - cytology Pancreas - embryology Pancreas - metabolism Receptors, Notch Smad2 Protein Trans-Activators - metabolism
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