Plasma Membrane Estrogen Receptors Exist and Functions as Dimers

A small pool of estrogen receptors (ERα and -β) localize at the plasma membrane and rapidly signal to affect cellular physiology. Although nuclear ERs function mainly as homodimers, it is unknown whether membrane-localized ER exists or functions with similar requirements. We report that the endogeno...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2004-12, Vol.18 (12), p.2854-2865
Hauptverfasser:	Razandi, Mahnaz, Pedram, Ali, Merchenthaler, Istvan, Greene, Geoffrey L, Levin, Ellis R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Breast Neoplasms - metabolism Cell Membrane - physiology Cell Physiological Phenomena CHO Cells Cricetinae Cricetulus Cyclic AMP - metabolism Dimerization Endothelial Cells - metabolism Estradiol - pharmacology Estradiol - physiology Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Estrogen Receptor alpha - physiology Extracellular Signal-Regulated MAP Kinases - metabolism Female GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism GTP-Binding Protein alpha Subunits, Gs - metabolism Humans Mice Mice, Knockout Mutation - genetics Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Receptor, Epidermal Growth Factor - metabolism Signal Transduction
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