Bcl-2 overexpression leads to increases in suppressor of cytokine signaling-3 expression in B cells and de novo follicular lymphoma

The t(14;18)(q32;q21), resulting in deregulated expression of B-cell-leukemia/lymphoma-2 (Bcl-2), represents the genetic hallmark in human follicular lymphomas. Substantial evidence supports the hypothesis that the t(14;18) and Bcl-2 overexpression are necessary but not solely responsible for neopla...

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Veröffentlicht in:	Molecular cancer research 2004-11, Vol.2 (11), p.620-631
Hauptverfasser:	Vanasse, Gary J, Winn, Robert K, Rodov, Sofya, Zieske, Arthur W, Li, John T, Tupper, Joan C, Tang, Jingjing, Raines, Elaine W, Peters, Mette A, Yeung, Ka Yee, Harlan, John M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - metabolism Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cell Line DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Down-Regulation - genetics Female Gene Expression Profiling Gene Expression Regulation, Neoplastic - genetics Gene Silencing - physiology Humans Lymphoma, Follicular - genetics Lymphoma, Follicular - metabolism Male Mice Mice, Inbred C57BL Mice, Transgenic Oligonucleotide Array Sequence Analysis Palatine Tonsil - metabolism Palatine Tonsil - pathology Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism STAT3 Transcription Factor Suppressor of Cytokine Signaling 3 Protein Suppressor of Cytokine Signaling Proteins Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors - genetics Transcription Factors - metabolism Transcriptional Activation - genetics Up-Regulation - genetics
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