One step ahead: Role of filopodia in adhesion formation during cell migration of keratinocytes

Cell adhesion is an essential prerequisite for cell function and movement. It depends strongly on focal adhesion complexes connecting the extracellular matrix to the actin cytoskeleton. Especially in moving cells focal adhesions are highly dynamic and believed to be formed closely behind the leading...

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Veröffentlicht in:	Experimental cell research 2009-04, Vol.315 (7), p.1212-1224
Hauptverfasser:	Schäfer, Claudia, Borm, Bodo, Born, Simone, Möhl, Christoph, Eibl, Eva-Maria, Hoffmann, Bernd
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cell adhesion Cell adhesion & migration Cell Adhesion - physiology Cell Adhesion Molecules - metabolism Cell migration Cell Movement - physiology Cells, Cultured Cellular biology Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Fascin Filopodium Fluorescence Recovery After Photobleaching Focal adhesion Focal Adhesions - metabolism Glycoproteins - genetics Glycoproteins - metabolism Humans Keratinocytes Keratinocytes - cytology Keratinocytes - physiology Microfilament Proteins - metabolism Paxillin - genetics Paxillin - metabolism Phosphoproteins - metabolism Pseudopodia - metabolism Pseudopodia - ultrastructure Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Substrates Talin - genetics Talin - metabolism Tip complex VASP Vinculin - genetics Vinculin - metabolism Zyxin
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