Partial leptin restoration increases hypothalamic-pituitary-adrenal activity while diminishing weight loss and hyperphagia in streptozotocin diabetic rats

Chronic leptin administration at pharmacologic doses normalizes food intake and body weight in streptozotocin (STZ)-diabetic rats. We examined the metabolic effects of acute partial physiological leptin restoration in STZ-diabetic rats by using subcutaneous osmotic mini pumps. Groups: (1) Rats infus...

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Veröffentlicht in:	Metabolism, clinical and experimental clinical and experimental, 2004-12, Vol.53 (12), p.1558-1564
Hauptverfasser:	Akirav, Eitan M., Chan, Owen, Inouye, Karen, Riddell, Michael C., Matthews, Stephen G., Vranic, Mladen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic Hormone - blood Animals Biological and medical sciences Blood Glucose Body Weight - drug effects Corticosterone - blood Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - metabolism Diabetes. Impaired glucose tolerance Eating - drug effects Endocrine pancreas. Apud cells (diseases) Endocrinopathies Epinephrine - blood Etiopathogenesis. Screening. Investigations. Target tissue resistance Hyperphagia - blood Hyperphagia - drug therapy Hyperphagia - etiology Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - metabolism Insulin - blood Leptin - pharmacology Male Medical sciences Mice Norepinephrine - blood Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - metabolism Pro-Opiomelanocortin - biosynthesis Rats Rats, Sprague-Dawley Receptors, Glucocorticoid - biosynthesis Recombinant Proteins - pharmacology RNA, Messenger - biosynthesis
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