Hormonal Regulation of Metastasis-Associated Protein 3 Transcription in Breast Cancer Cells

Metastasis-associated protein 3 (MTA3) is a cell type-specific subunit of the Mi-2/NuRD transcriptional corepressor complex. In breast cancer cells, MTA3 and the Mi-2/NuRD complex mediate repression of Snail, a transcription factor that promotes epithelial to mesenchymal transitions. Thus, MTA3 func...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2004-12, Vol.18 (12), p.2937-2949
Hauptverfasser:	Fujita, Naoyuki, Kajita, Masahiro, Taysavang, Panya, Wade, Paul A
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Breast Neoplasms - genetics Breast Neoplasms - metabolism Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Estrogen Receptor alpha - physiology Estrogens - pharmacology Estrogens - physiology Female Gene Expression Regulation, Neoplastic Genes, Reporter - genetics Histone Deacetylases - genetics Histone Deacetylases - metabolism Humans Luciferases - analysis Luciferases - genetics Molecular Sequence Data Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Response Elements - genetics RNA Interference RNA, Messenger - analysis RNA, Messenger - metabolism Sp1 Transcription Factor - genetics Sp1 Transcription Factor - metabolism Sp1 Transcription Factor - physiology Trans-Activators Transcription, Genetic
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