Decrease in Adiponectin Levels Correlates to Growth Response in Growth Hormone-Treated Children
Background/Aims: Adiponectin is secreted by adipose tissue and circulates in human plasma at high levels. Decreased adiponectin levels are associated with insulin resistance and obesity. The aim of this study was to investigate whether changes in serum adiponectin levels are related to the growth re...
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| Veröffentlicht in: | HORMONE RESEARCH IN PAEDIATRICS 2009-01, Vol.71 (4), p.213-218 |
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| creator | Andersson, B. Carlsson, L.M.S. Carlsson, B. Albertsson-Wikland, K. Bjarnason, R. |
| description | Background/Aims: Adiponectin is secreted by adipose tissue and circulates in human plasma at high levels. Decreased adiponectin levels are associated with insulin resistance and obesity. The aim of this study was to investigate whether changes in serum adiponectin levels are related to the growth response, insulin levels and insulin resistance during growth hormone (GH) treatment. Methods: The study included 94 short prepubertal children (19 girls and 75 boys). The mean age at the start of daily GH injections was 9.04 ± 2.38 years. Adiponectin levels in serum were measured using an ELISA. Results: At baseline, adiponectin correlated with the first-year growth response (r = 0.26, p = 0.012). Adiponectin decreased significantly after 1 week, 3 months and 1 year from 14.5 ± 5.71 to 13.1 ± 5.22 (p < 0.0001), 10.3 ± 4.82 (p < 0.0001) and 12.5 ± 5.34 μg/ml (p < 0.0001), respectively. There were significant correlations between the first-year growth response and the decrease in adiponectin levels after 3 months and 1 year (r = –0.38, p < 0.0001 and r = –0.47, p < 0.0001, respectively). No correlations between adiponectin, insulin and the homeostasis model assessment of insulin resistance were seen. Conclusions: GH treatment in prepubertal children decreases serum adiponectin levels, and the decrease is correlated to the growth response. No correlations between adiponectin and insulin levels or insulin resistance were found. |
| doi_str_mv | 10.1159/000201110 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_proquest_miscellaneous_67105032</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2770088371</sourcerecordid><originalsourceid>FETCH-LOGICAL-c412t-30173101fa1e5370ac6c429b34ca2f590a884a7106992f1da93f3772eccb5e023</originalsourceid><addsrcrecordid>eNqN0uFr1TAQAPAgihvbPvhdpCAIA6u5pGmaj4-3uQ0eCDL9GvLS61u3tqlJ49h_vzxaniAofspx_O5CLkfIG6CfAIT6TCllFADoC3IMZclzVrHy5SGG6oichXCfGOWVVCBfkyNQTFQS-DHRF2g9moBZO2Sruh3dgHZK8QZ_YReytfMeOzNhyCaXXXn3ON1l3zAkN9csqWvn-1Sa36ZmE9bZ-q7tao_DKXnVmC7g2XKekO9fLm_X1_nm69XNerXJbQFsyjkFyYFCYwAFl9TY0hZMbXlhDWuEoqaqCiOBlkqxBmqjeMOlZGjtViBl_ITkc9_wiGPc6tG3vfFP2plWL6mHFKEWQvFC_NPv4qhTahf3HgSUUib_8a_-ov2x0s7vdIwaGCto9Z-8j5qL9HuJf5j56N3PiGHSfRssdp0Z0MWgy_RyQfn-me__gPcu-iFNVu9nkyZXCEjqfFbWuxA8Nof7ger90ujD0iT7bukYtz3Wv-WyIgm8ncGD8Tv0B7DUPwOuQcRg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1069370451</pqid></control><display><type>article</type><title>Decrease in Adiponectin Levels Correlates to Growth Response in Growth Hormone-Treated Children</title><source>Karger Journals</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Andersson, B. ; Carlsson, L.M.S. ; Carlsson, B. ; Albertsson-Wikland, K. ; Bjarnason, R.</creator><creatorcontrib>Andersson, B. ; Carlsson, L.M.S. ; Carlsson, B. ; Albertsson-Wikland, K. ; Bjarnason, R. ; Swedish Study Group for Growth Hormone Treatment</creatorcontrib><description>Background/Aims: Adiponectin is secreted by adipose tissue and circulates in human plasma at high levels. Decreased adiponectin levels are associated with insulin resistance and obesity. The aim of this study was to investigate whether changes in serum adiponectin levels are related to the growth response, insulin levels and insulin resistance during growth hormone (GH) treatment. Methods: The study included 94 short prepubertal children (19 girls and 75 boys). The mean age at the start of daily GH injections was 9.04 ± 2.38 years. Adiponectin levels in serum were measured using an ELISA. Results: At baseline, adiponectin correlated with the first-year growth response (r = 0.26, p = 0.012). Adiponectin decreased significantly after 1 week, 3 months and 1 year from 14.5 ± 5.71 to 13.1 ± 5.22 (p < 0.0001), 10.3 ± 4.82 (p < 0.0001) and 12.5 ± 5.34 μg/ml (p < 0.0001), respectively. There were significant correlations between the first-year growth response and the decrease in adiponectin levels after 3 months and 1 year (r = –0.38, p < 0.0001 and r = –0.47, p < 0.0001, respectively). No correlations between adiponectin, insulin and the homeostasis model assessment of insulin resistance were seen. Conclusions: GH treatment in prepubertal children decreases serum adiponectin levels, and the decrease is correlated to the growth response. No correlations between adiponectin and insulin levels or insulin resistance were found.</description><identifier>ISSN: 1663-2818</identifier><identifier>ISSN: 0301-0163</identifier><identifier>ISSN: 1423-0046</identifier><identifier>EISSN: 1663-2826</identifier><identifier>EISSN: 1423-0046</identifier><identifier>DOI: 10.1159/000201110</identifier><identifier>PMID: 19258713</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adiponectin ; Adiponectin - blood ; Adolescent ; blood ; Child ; Child Development ; Child, Preschool ; Children ; Female ; Growth hormone ; Growth response ; Human Growth Hormone ; Human Growth Hormone - therapeutic use ; Humans ; Insulin ; Insulin Resistance ; Insulin-like growth factor-I ; Male ; Original Paper ; Pediatrics ; Pediatrik ; Preschool ; therapeutic use</subject><ispartof>HORMONE RESEARCH IN PAEDIATRICS, 2009-01, Vol.71 (4), p.213-218</ispartof><rights>2009 S. Karger AG, Basel</rights><rights>2009 S. Karger AG, Basel.</rights><rights>Copyright (c) 2009 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-30173101fa1e5370ac6c429b34ca2f590a884a7106992f1da93f3772eccb5e023</citedby><cites>FETCH-LOGICAL-c412t-30173101fa1e5370ac6c429b34ca2f590a884a7106992f1da93f3772eccb5e023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,2423,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19258713$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-35020$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-122408$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/151677$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:118394013$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Andersson, B.</creatorcontrib><creatorcontrib>Carlsson, L.M.S.</creatorcontrib><creatorcontrib>Carlsson, B.</creatorcontrib><creatorcontrib>Albertsson-Wikland, K.</creatorcontrib><creatorcontrib>Bjarnason, R.</creatorcontrib><creatorcontrib>Swedish Study Group for Growth Hormone Treatment</creatorcontrib><title>Decrease in Adiponectin Levels Correlates to Growth Response in Growth Hormone-Treated Children</title><title>HORMONE RESEARCH IN PAEDIATRICS</title><addtitle>Horm Res Paediatr</addtitle><description>Background/Aims: Adiponectin is secreted by adipose tissue and circulates in human plasma at high levels. Decreased adiponectin levels are associated with insulin resistance and obesity. The aim of this study was to investigate whether changes in serum adiponectin levels are related to the growth response, insulin levels and insulin resistance during growth hormone (GH) treatment. Methods: The study included 94 short prepubertal children (19 girls and 75 boys). The mean age at the start of daily GH injections was 9.04 ± 2.38 years. Adiponectin levels in serum were measured using an ELISA. Results: At baseline, adiponectin correlated with the first-year growth response (r = 0.26, p = 0.012). Adiponectin decreased significantly after 1 week, 3 months and 1 year from 14.5 ± 5.71 to 13.1 ± 5.22 (p < 0.0001), 10.3 ± 4.82 (p < 0.0001) and 12.5 ± 5.34 μg/ml (p < 0.0001), respectively. There were significant correlations between the first-year growth response and the decrease in adiponectin levels after 3 months and 1 year (r = –0.38, p < 0.0001 and r = –0.47, p < 0.0001, respectively). No correlations between adiponectin, insulin and the homeostasis model assessment of insulin resistance were seen. Conclusions: GH treatment in prepubertal children decreases serum adiponectin levels, and the decrease is correlated to the growth response. No correlations between adiponectin and insulin levels or insulin resistance were found.</description><subject>Adiponectin</subject><subject>Adiponectin - blood</subject><subject>Adolescent</subject><subject>blood</subject><subject>Child</subject><subject>Child Development</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Female</subject><subject>Growth hormone</subject><subject>Growth response</subject><subject>Human Growth Hormone</subject><subject>Human Growth Hormone - therapeutic use</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>Insulin-like growth factor-I</subject><subject>Male</subject><subject>Original Paper</subject><subject>Pediatrics</subject><subject>Pediatrik</subject><subject>Preschool</subject><subject>therapeutic use</subject><issn>1663-2818</issn><issn>0301-0163</issn><issn>1423-0046</issn><issn>1663-2826</issn><issn>1423-0046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqN0uFr1TAQAPAgihvbPvhdpCAIA6u5pGmaj4-3uQ0eCDL9GvLS61u3tqlJ49h_vzxaniAofspx_O5CLkfIG6CfAIT6TCllFADoC3IMZclzVrHy5SGG6oichXCfGOWVVCBfkyNQTFQS-DHRF2g9moBZO2Sruh3dgHZK8QZ_YReytfMeOzNhyCaXXXn3ON1l3zAkN9csqWvn-1Sa36ZmE9bZ-q7tao_DKXnVmC7g2XKekO9fLm_X1_nm69XNerXJbQFsyjkFyYFCYwAFl9TY0hZMbXlhDWuEoqaqCiOBlkqxBmqjeMOlZGjtViBl_ITkc9_wiGPc6tG3vfFP2plWL6mHFKEWQvFC_NPv4qhTahf3HgSUUib_8a_-ov2x0s7vdIwaGCto9Z-8j5qL9HuJf5j56N3PiGHSfRssdp0Z0MWgy_RyQfn-me__gPcu-iFNVu9nkyZXCEjqfFbWuxA8Nof7ger90ujD0iT7bukYtz3Wv-WyIgm8ncGD8Tv0B7DUPwOuQcRg</recordid><startdate>20090101</startdate><enddate>20090101</enddate><creator>Andersson, B.</creator><creator>Carlsson, L.M.S.</creator><creator>Carlsson, B.</creator><creator>Albertsson-Wikland, K.</creator><creator>Bjarnason, R.</creator><general>S. 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Decreased adiponectin levels are associated with insulin resistance and obesity. The aim of this study was to investigate whether changes in serum adiponectin levels are related to the growth response, insulin levels and insulin resistance during growth hormone (GH) treatment. Methods: The study included 94 short prepubertal children (19 girls and 75 boys). The mean age at the start of daily GH injections was 9.04 ± 2.38 years. Adiponectin levels in serum were measured using an ELISA. Results: At baseline, adiponectin correlated with the first-year growth response (r = 0.26, p = 0.012). Adiponectin decreased significantly after 1 week, 3 months and 1 year from 14.5 ± 5.71 to 13.1 ± 5.22 (p < 0.0001), 10.3 ± 4.82 (p < 0.0001) and 12.5 ± 5.34 μg/ml (p < 0.0001), respectively. There were significant correlations between the first-year growth response and the decrease in adiponectin levels after 3 months and 1 year (r = –0.38, p < 0.0001 and r = –0.47, p < 0.0001, respectively). No correlations between adiponectin, insulin and the homeostasis model assessment of insulin resistance were seen. Conclusions: GH treatment in prepubertal children decreases serum adiponectin levels, and the decrease is correlated to the growth response. No correlations between adiponectin and insulin levels or insulin resistance were found.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>19258713</pmid><doi>10.1159/000201110</doi><tpages>6</tpages></addata></record> |
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| subjects | Adiponectin Adiponectin - blood Adolescent blood Child Child Development Child, Preschool Children Female Growth hormone Growth response Human Growth Hormone Human Growth Hormone - therapeutic use Humans Insulin Insulin Resistance Insulin-like growth factor-I Male Original Paper Pediatrics Pediatrik Preschool therapeutic use |
| title | Decrease in Adiponectin Levels Correlates to Growth Response in Growth Hormone-Treated Children |
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