Hyaluronan inhibits bone resorption by suppressing prostaglandin E synthesis in osteoblasts treated with interleukin-1
Hyaluronan (HA), a large glycosaminoglycan, is a component of the extra-cellular matrix in various tissues. HA is essential for matrix assembly and fluid viscosity in cartilage, but the roles of HA in bone are unclear. Bone resorption associated with inflammation is closely related to prostaglandin...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2009-04, Vol.381 (2), p.139-143 |
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| creator | Hirata, Michiko Kobayashi, Megumi Takita, Morichika Matsumoto, Chiho Miyaura, Chisato Inada, Masaki |
| description | Hyaluronan (HA), a large glycosaminoglycan, is a component of the extra-cellular matrix in various tissues. HA is essential for matrix assembly and fluid viscosity in cartilage, but the roles of HA in bone are unclear. Bone resorption associated with inflammation is closely related to prostaglandin E (PGE) synthesis by osteoblasts induced by cytokines such as interleukin-1 (IL-1). In mouse calvarial cultures, HA inhibited osteoclastic bone resorption and PGE production induced by IL-1. In mouse osteoblasts, HA suppressed IL-1-induced expression of cyclooxygenase(COX)-2 and membrane-bound PGE synthase (mPGES)-1 mRNAs, and PGE
2 production. Matrix metalloproteinases (MMPs), including MMP-2 and MMP-13, were produced by osteoblasts in response to IL-1, and were clearly suppressed by HA. In osteoblasts, HA suppressed the NFκB-dependent transcription in a luciferase assay. Therefore, HA acts on osteoblasts to suppress the production of PGE
2 and MMPs, and inhibits bone resorption, suggesting critical roles of HA in pathological bone loss with inflammation. |
| doi_str_mv | 10.1016/j.bbrc.2009.01.146 |
| format | Article |
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2 production. Matrix metalloproteinases (MMPs), including MMP-2 and MMP-13, were produced by osteoblasts in response to IL-1, and were clearly suppressed by HA. In osteoblasts, HA suppressed the NFκB-dependent transcription in a luciferase assay. Therefore, HA acts on osteoblasts to suppress the production of PGE
2 and MMPs, and inhibits bone resorption, suggesting critical roles of HA in pathological bone loss with inflammation.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2009.01.146</identifier><identifier>PMID: 19338766</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Bone resorption ; Bone Resorption - metabolism ; Cells, Cultured ; Cyclooxygenase 2 - metabolism ; Dinoprostone - antagonists & inhibitors ; Dinoprostone - biosynthesis ; Hyaluronan ; Hyaluronic Acid - pharmacology ; Interleukin-1 ; Interleukin-1 - pharmacology ; Intramolecular Oxidoreductases - metabolism ; Matrix metalloproteinase ; Matrix Metalloproteinase 13 - metabolism ; Mice ; Mice, Inbred Strains ; Osteoblasts ; Osteoblasts - drug effects ; Osteoblasts - metabolism ; Prostaglandin E ; Prostaglandin-E Synthases ; RANK Ligand - metabolism ; Skull - drug effects</subject><ispartof>Biochemical and biophysical research communications, 2009-04, Vol.381 (2), p.139-143</ispartof><rights>2009 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-31b9ef7a6812eab9a706c42d9769531c34c422b018e8cd260bdbe981b267cd333</citedby><cites>FETCH-LOGICAL-c385t-31b9ef7a6812eab9a706c42d9769531c34c422b018e8cd260bdbe981b267cd333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006291X09001661$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19338766$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hirata, Michiko</creatorcontrib><creatorcontrib>Kobayashi, Megumi</creatorcontrib><creatorcontrib>Takita, Morichika</creatorcontrib><creatorcontrib>Matsumoto, Chiho</creatorcontrib><creatorcontrib>Miyaura, Chisato</creatorcontrib><creatorcontrib>Inada, Masaki</creatorcontrib><title>Hyaluronan inhibits bone resorption by suppressing prostaglandin E synthesis in osteoblasts treated with interleukin-1</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Hyaluronan (HA), a large glycosaminoglycan, is a component of the extra-cellular matrix in various tissues. HA is essential for matrix assembly and fluid viscosity in cartilage, but the roles of HA in bone are unclear. Bone resorption associated with inflammation is closely related to prostaglandin E (PGE) synthesis by osteoblasts induced by cytokines such as interleukin-1 (IL-1). In mouse calvarial cultures, HA inhibited osteoclastic bone resorption and PGE production induced by IL-1. In mouse osteoblasts, HA suppressed IL-1-induced expression of cyclooxygenase(COX)-2 and membrane-bound PGE synthase (mPGES)-1 mRNAs, and PGE
2 production. Matrix metalloproteinases (MMPs), including MMP-2 and MMP-13, were produced by osteoblasts in response to IL-1, and were clearly suppressed by HA. In osteoblasts, HA suppressed the NFκB-dependent transcription in a luciferase assay. Therefore, HA acts on osteoblasts to suppress the production of PGE
2 and MMPs, and inhibits bone resorption, suggesting critical roles of HA in pathological bone loss with inflammation.</description><subject>Animals</subject><subject>Bone resorption</subject><subject>Bone Resorption - metabolism</subject><subject>Cells, Cultured</subject><subject>Cyclooxygenase 2 - metabolism</subject><subject>Dinoprostone - antagonists & inhibitors</subject><subject>Dinoprostone - biosynthesis</subject><subject>Hyaluronan</subject><subject>Hyaluronic Acid - pharmacology</subject><subject>Interleukin-1</subject><subject>Interleukin-1 - pharmacology</subject><subject>Intramolecular Oxidoreductases - metabolism</subject><subject>Matrix metalloproteinase</subject><subject>Matrix Metalloproteinase 13 - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Osteoblasts</subject><subject>Osteoblasts - drug effects</subject><subject>Osteoblasts - metabolism</subject><subject>Prostaglandin E</subject><subject>Prostaglandin-E Synthases</subject><subject>RANK Ligand - metabolism</subject><subject>Skull - drug effects</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUGLFDEQhYMo7rj6BzxITt66rUpm0h3wIsvqCgteFLyFJF2zk7En3SbpXebfm2EGvOmpqKqvHsV7jL1FaBFQfdi3ziXfCgDdAra4Vs_YCkFDIxDWz9kKAFQjNP68Yq9y3gNgZfRLdoVayr5TasUe7452XNIUbeQh7oILJXM3ReKJ8pTmEqbI3ZHnZZ7rJIf4wOc05WIfRhuHEPktz8dYdpRDrgq8rmhyo81VpySyhQb-FMqu7gqlkZZfITb4mr3Y2jHTm0u9Zj8-336_uWvuv335evPpvvGy35RGotO07azqUZB12nag_FoMulN6I9HLde2EA-yp94NQ4AZHukcnVOcHKeU1e3_WrT__XigXcwjZ01h_p2nJRnUIssPuv6CAtew2uq-gOIO-upATbc2cwsGmo0Ewp1jM3pxiMadYDKCpltejdxf1xR1o-HtyyaECH88AVTMeAyWTfaDoaQiJfDHDFP6l_wfJ96EY</recordid><startdate>20090403</startdate><enddate>20090403</enddate><creator>Hirata, Michiko</creator><creator>Kobayashi, Megumi</creator><creator>Takita, Morichika</creator><creator>Matsumoto, Chiho</creator><creator>Miyaura, Chisato</creator><creator>Inada, Masaki</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20090403</creationdate><title>Hyaluronan inhibits bone resorption by suppressing prostaglandin E synthesis in osteoblasts treated with interleukin-1</title><author>Hirata, Michiko ; Kobayashi, Megumi ; Takita, Morichika ; Matsumoto, Chiho ; Miyaura, Chisato ; Inada, Masaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-31b9ef7a6812eab9a706c42d9769531c34c422b018e8cd260bdbe981b267cd333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Bone resorption</topic><topic>Bone Resorption - metabolism</topic><topic>Cells, Cultured</topic><topic>Cyclooxygenase 2 - metabolism</topic><topic>Dinoprostone - antagonists & inhibitors</topic><topic>Dinoprostone - biosynthesis</topic><topic>Hyaluronan</topic><topic>Hyaluronic Acid - pharmacology</topic><topic>Interleukin-1</topic><topic>Interleukin-1 - pharmacology</topic><topic>Intramolecular Oxidoreductases - metabolism</topic><topic>Matrix metalloproteinase</topic><topic>Matrix Metalloproteinase 13 - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Osteoblasts</topic><topic>Osteoblasts - drug effects</topic><topic>Osteoblasts - metabolism</topic><topic>Prostaglandin E</topic><topic>Prostaglandin-E Synthases</topic><topic>RANK Ligand - metabolism</topic><topic>Skull - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hirata, Michiko</creatorcontrib><creatorcontrib>Kobayashi, Megumi</creatorcontrib><creatorcontrib>Takita, Morichika</creatorcontrib><creatorcontrib>Matsumoto, Chiho</creatorcontrib><creatorcontrib>Miyaura, Chisato</creatorcontrib><creatorcontrib>Inada, Masaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hirata, Michiko</au><au>Kobayashi, Megumi</au><au>Takita, Morichika</au><au>Matsumoto, Chiho</au><au>Miyaura, Chisato</au><au>Inada, Masaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyaluronan inhibits bone resorption by suppressing prostaglandin E synthesis in osteoblasts treated with interleukin-1</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2009-04-03</date><risdate>2009</risdate><volume>381</volume><issue>2</issue><spage>139</spage><epage>143</epage><pages>139-143</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Hyaluronan (HA), a large glycosaminoglycan, is a component of the extra-cellular matrix in various tissues. HA is essential for matrix assembly and fluid viscosity in cartilage, but the roles of HA in bone are unclear. Bone resorption associated with inflammation is closely related to prostaglandin E (PGE) synthesis by osteoblasts induced by cytokines such as interleukin-1 (IL-1). In mouse calvarial cultures, HA inhibited osteoclastic bone resorption and PGE production induced by IL-1. In mouse osteoblasts, HA suppressed IL-1-induced expression of cyclooxygenase(COX)-2 and membrane-bound PGE synthase (mPGES)-1 mRNAs, and PGE
2 production. Matrix metalloproteinases (MMPs), including MMP-2 and MMP-13, were produced by osteoblasts in response to IL-1, and were clearly suppressed by HA. In osteoblasts, HA suppressed the NFκB-dependent transcription in a luciferase assay. Therefore, HA acts on osteoblasts to suppress the production of PGE
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| subjects | Animals Bone resorption Bone Resorption - metabolism Cells, Cultured Cyclooxygenase 2 - metabolism Dinoprostone - antagonists & inhibitors Dinoprostone - biosynthesis Hyaluronan Hyaluronic Acid - pharmacology Interleukin-1 Interleukin-1 - pharmacology Intramolecular Oxidoreductases - metabolism Matrix metalloproteinase Matrix Metalloproteinase 13 - metabolism Mice Mice, Inbred Strains Osteoblasts Osteoblasts - drug effects Osteoblasts - metabolism Prostaglandin E Prostaglandin-E Synthases RANK Ligand - metabolism Skull - drug effects |
| title | Hyaluronan inhibits bone resorption by suppressing prostaglandin E synthesis in osteoblasts treated with interleukin-1 |
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