Pharmacologically relevant receptor binding characteristics and 5alpha-reductase inhibitory activity of free Fatty acids contained in saw palmetto extract

Saw palmetto extract (SPE), used widely for the treatment of benign prostatic hyperplasia (BPH) has been shown to bind alpha(1)-adrenergic, muscarinic and 1,4-dihydropyridine (1,4-DHP) calcium channel antagonist receptors. Major constituents of SPE are lauric acid, oleic acid, myristic acid, palmiti...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2009-01, Vol.32 (4), p.646-650
Hauptverfasser:	Abe, Masayuki, Ito, Yoshihiko, Oyunzul, Luvsandorj, Oki-Fujino, Tomomi, Yamada, Shizuo
Format:	Artikel
Sprache:	eng
Schlagworte:	5-alpha Reductase Inhibitors Adrenergic alpha-Antagonists - metabolism Animals Binding, Competitive - drug effects Calcium Channel Blockers - metabolism Calcium Channels, L-Type - drug effects Calcium Channels, L-Type - metabolism Fatty Acids, Nonesterified - chemistry Fatty Acids, Nonesterified - pharmacology Female Isradipine - metabolism Liver - drug effects Liver - enzymology Male Microsomes, Liver - drug effects Microsomes, Liver - metabolism Muscarinic Agonists - metabolism N-Methylscopolamine - metabolism Plant Extracts - chemistry Plant Extracts - pharmacology Prazosin - metabolism Radioligand Assay Rats Rats, Sprague-Dawley Receptors, Adrenergic, alpha-1 - drug effects Receptors, Adrenergic, alpha-1 - metabolism Receptors, Muscarinic - drug effects Receptors, Muscarinic - metabolism Serenoa - chemistry
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