Inflammation, Abdominal Obesity, and Smoking as Predictors of Hypertension
Development of hypertension has been linked to chronic low-grade inflammation. However, it is not known whether this connection is mediated by features of the metabolic syndrome or smoking, or their changes, which themselves have been linked to inflammation. We studied the predictive value of highly...
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| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 2004-12, Vol.44 (6), p.859-865 |
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| container_title | Hypertension (Dallas, Tex. 1979) |
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| creator | Niskanen, Leo Laaksonen, David E Nyyssönen, Kristiina Punnonen, Kari Valkonen, Veli-Pekka Fuentes, Ricardo Tuomainen, Tomi-Pekka Salonen, Riitta Salonen, Jukka T |
| description | Development of hypertension has been linked to chronic low-grade inflammation. However, it is not known whether this connection is mediated by features of the metabolic syndrome or smoking, or their changes, which themselves have been linked to inflammation. We studied the predictive value of highly sensitive C-reactive protein (hs-CRP), smoking, and abdominal obesity to the development of hypertension in an 11-year follow-up of a population-based study cohort comprising 379 middle-aged normotensive men. During the follow-up, 124 men (33%) developed hypertension. Men with hs-CRP ≥3.0 mg/L were 2.8× (95% confidence interval, 1.2 to 6.6) more likely to develop hypertension than with hs-CRP |
| doi_str_mv | 10.1161/01.HYP.0000146691.51307.84 |
| format | Article |
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However, it is not known whether this connection is mediated by features of the metabolic syndrome or smoking, or their changes, which themselves have been linked to inflammation. We studied the predictive value of highly sensitive C-reactive protein (hs-CRP), smoking, and abdominal obesity to the development of hypertension in an 11-year follow-up of a population-based study cohort comprising 379 middle-aged normotensive men. During the follow-up, 124 men (33%) developed hypertension. Men with hs-CRP ≥3.0 mg/L were 2.8× (95% confidence interval, 1.2 to 6.6) more likely to develop hypertension than with hs-CRP <1.0 mg/L even after adjustment for features of the metabolic syndrome, lifestyle factors, and their changes. Cigarette smoking was also associated with development of hypertension independently of inflammation and other confounders. Waist girth increased more in men who quit smoking than in other men. An increase in waist girth during follow-up strongly predicted incident hypertension. The decrease in smoking was not associated with a lower risk of hypertension in age-adjusted analyses. Hypertension is preceded by low-grade chronic inflammation in middle-aged white men independently of smoking or features of the metabolic syndrome. Furthermore, smoking may be a risk factor for hypertension. Although stopping smoking is beneficial with respect to health outcomes, the subsequent increase in weight and waist girth associated with smoking cessation may offset the decrease in the risk of hypertension that one may otherwise expect.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/01.HYP.0000146691.51307.84</identifier><identifier>PMID: 15492131</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Alcohol Drinking ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; C-Reactive Protein - metabolism ; Cardiology. Vascular system ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Follow-Up Studies ; Humans ; Hypertension - epidemiology ; Hypertension - etiology ; Hypertension - physiopathology ; Inflammation - physiopathology ; Male ; Medical sciences ; Metabolic diseases ; Metabolic Syndrome - physiopathology ; Middle Aged ; Obesity ; Obesity - physiopathology ; Risk Factors ; Smoking - physiopathology ; Waist-Hip Ratio</subject><ispartof>Hypertension (Dallas, Tex. 1979), 2004-12, Vol.44 (6), p.859-865</ispartof><rights>2004 American Heart Association, Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5495-ae54e89f3fe45cf83f501c66fde549ba54b2d96ef507c18addf59eba71d47bba3</citedby><cites>FETCH-LOGICAL-c5495-ae54e89f3fe45cf83f501c66fde549ba54b2d96ef507c18addf59eba71d47bba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,3691,27933,27934</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16315467$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15492131$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Niskanen, Leo</creatorcontrib><creatorcontrib>Laaksonen, David E</creatorcontrib><creatorcontrib>Nyyssönen, Kristiina</creatorcontrib><creatorcontrib>Punnonen, Kari</creatorcontrib><creatorcontrib>Valkonen, Veli-Pekka</creatorcontrib><creatorcontrib>Fuentes, Ricardo</creatorcontrib><creatorcontrib>Tuomainen, Tomi-Pekka</creatorcontrib><creatorcontrib>Salonen, Riitta</creatorcontrib><creatorcontrib>Salonen, Jukka T</creatorcontrib><title>Inflammation, Abdominal Obesity, and Smoking as Predictors of Hypertension</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>Development of hypertension has been linked to chronic low-grade inflammation. However, it is not known whether this connection is mediated by features of the metabolic syndrome or smoking, or their changes, which themselves have been linked to inflammation. We studied the predictive value of highly sensitive C-reactive protein (hs-CRP), smoking, and abdominal obesity to the development of hypertension in an 11-year follow-up of a population-based study cohort comprising 379 middle-aged normotensive men. During the follow-up, 124 men (33%) developed hypertension. Men with hs-CRP ≥3.0 mg/L were 2.8× (95% confidence interval, 1.2 to 6.6) more likely to develop hypertension than with hs-CRP <1.0 mg/L even after adjustment for features of the metabolic syndrome, lifestyle factors, and their changes. Cigarette smoking was also associated with development of hypertension independently of inflammation and other confounders. Waist girth increased more in men who quit smoking than in other men. An increase in waist girth during follow-up strongly predicted incident hypertension. The decrease in smoking was not associated with a lower risk of hypertension in age-adjusted analyses. Hypertension is preceded by low-grade chronic inflammation in middle-aged white men independently of smoking or features of the metabolic syndrome. Furthermore, smoking may be a risk factor for hypertension. Although stopping smoking is beneficial with respect to health outcomes, the subsequent increase in weight and waist girth associated with smoking cessation may offset the decrease in the risk of hypertension that one may otherwise expect.</description><subject>Alcohol Drinking</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiology. Vascular system</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hypertension - epidemiology</subject><subject>Hypertension - etiology</subject><subject>Hypertension - physiopathology</subject><subject>Inflammation - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metabolic Syndrome - physiopathology</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - physiopathology</subject><subject>Risk Factors</subject><subject>Smoking - physiopathology</subject><subject>Waist-Hip Ratio</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEFv1DAQhS0EokvhL6AICU5N8CS2k3CrKmCLKrUSIMHJmthjGurEi51Vtf8eb3el9cEjeb7nN_MYewe8AlDwkUO1_n1X8XxAKNVDJaHhbdWJZ2wFshalkKp5zlYcelH2AL_O2KuU_u5xIdqX7Ayk6GtoYMW-Xc_O4zThMob5orgcbJjGGX1xO1Aal91FgbMtvk_hYZz_FJiKu0h2NEuIqQiuWO82FBeaU1a_Zi8c-kRvjvWc_fzy-cfVury5_Xp9dXlTmuwqSyQpqOtd40hI47rGSQ5GKWdzox9QiqG2vaL83Bro0FonexqwBSvaYcDmnH04_LuJ4d-W0qKnMRnyHmcK26RVC3nRus3gpwNoYkgpktObOE4Ydxq43iepOeicpD4lqZ-S1J3I4rdHl-0wkT1Jj9Fl4P0RwGTQu4izGdOJU01G1X4KceAeg18opge_faSo7wn9cv9kLWrVlXWukC9e7oeRzX_Zuoyp</recordid><startdate>200412</startdate><enddate>200412</enddate><creator>Niskanen, Leo</creator><creator>Laaksonen, David E</creator><creator>Nyyssönen, Kristiina</creator><creator>Punnonen, Kari</creator><creator>Valkonen, Veli-Pekka</creator><creator>Fuentes, Ricardo</creator><creator>Tuomainen, Tomi-Pekka</creator><creator>Salonen, Riitta</creator><creator>Salonen, Jukka T</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200412</creationdate><title>Inflammation, Abdominal Obesity, and Smoking as Predictors of Hypertension</title><author>Niskanen, Leo ; Laaksonen, David E ; Nyyssönen, Kristiina ; Punnonen, Kari ; Valkonen, Veli-Pekka ; Fuentes, Ricardo ; Tuomainen, Tomi-Pekka ; Salonen, Riitta ; Salonen, Jukka T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5495-ae54e89f3fe45cf83f501c66fde549ba54b2d96ef507c18addf59eba71d47bba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Alcohol Drinking</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiology. Vascular system</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hypertension - epidemiology</topic><topic>Hypertension - etiology</topic><topic>Hypertension - physiopathology</topic><topic>Inflammation - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Metabolic Syndrome - physiopathology</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity - physiopathology</topic><topic>Risk Factors</topic><topic>Smoking - physiopathology</topic><topic>Waist-Hip Ratio</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Niskanen, Leo</creatorcontrib><creatorcontrib>Laaksonen, David E</creatorcontrib><creatorcontrib>Nyyssönen, Kristiina</creatorcontrib><creatorcontrib>Punnonen, Kari</creatorcontrib><creatorcontrib>Valkonen, Veli-Pekka</creatorcontrib><creatorcontrib>Fuentes, Ricardo</creatorcontrib><creatorcontrib>Tuomainen, Tomi-Pekka</creatorcontrib><creatorcontrib>Salonen, Riitta</creatorcontrib><creatorcontrib>Salonen, Jukka T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Niskanen, Leo</au><au>Laaksonen, David E</au><au>Nyyssönen, Kristiina</au><au>Punnonen, Kari</au><au>Valkonen, Veli-Pekka</au><au>Fuentes, Ricardo</au><au>Tuomainen, Tomi-Pekka</au><au>Salonen, Riitta</au><au>Salonen, Jukka T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inflammation, Abdominal Obesity, and Smoking as Predictors of Hypertension</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>2004-12</date><risdate>2004</risdate><volume>44</volume><issue>6</issue><spage>859</spage><epage>865</epage><pages>859-865</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>Development of hypertension has been linked to chronic low-grade inflammation. However, it is not known whether this connection is mediated by features of the metabolic syndrome or smoking, or their changes, which themselves have been linked to inflammation. We studied the predictive value of highly sensitive C-reactive protein (hs-CRP), smoking, and abdominal obesity to the development of hypertension in an 11-year follow-up of a population-based study cohort comprising 379 middle-aged normotensive men. During the follow-up, 124 men (33%) developed hypertension. Men with hs-CRP ≥3.0 mg/L were 2.8× (95% confidence interval, 1.2 to 6.6) more likely to develop hypertension than with hs-CRP <1.0 mg/L even after adjustment for features of the metabolic syndrome, lifestyle factors, and their changes. Cigarette smoking was also associated with development of hypertension independently of inflammation and other confounders. Waist girth increased more in men who quit smoking than in other men. An increase in waist girth during follow-up strongly predicted incident hypertension. The decrease in smoking was not associated with a lower risk of hypertension in age-adjusted analyses. Hypertension is preceded by low-grade chronic inflammation in middle-aged white men independently of smoking or features of the metabolic syndrome. Furthermore, smoking may be a risk factor for hypertension. Although stopping smoking is beneficial with respect to health outcomes, the subsequent increase in weight and waist girth associated with smoking cessation may offset the decrease in the risk of hypertension that one may otherwise expect.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>15492131</pmid><doi>10.1161/01.HYP.0000146691.51307.84</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Hypertension (Dallas, Tex. 1979), 2004-12, Vol.44 (6), p.859-865 |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Alcohol Drinking Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels C-Reactive Protein - metabolism Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Follow-Up Studies Humans Hypertension - epidemiology Hypertension - etiology Hypertension - physiopathology Inflammation - physiopathology Male Medical sciences Metabolic diseases Metabolic Syndrome - physiopathology Middle Aged Obesity Obesity - physiopathology Risk Factors Smoking - physiopathology Waist-Hip Ratio |
| title | Inflammation, Abdominal Obesity, and Smoking as Predictors of Hypertension |
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