Production of l-tryptophan-derived catabolites in hepatocytes from streptozotocin-induced diabetic rats

Background Recently the l-tryptophan (Trp) metabolites such as l-kynurenine(Kyn), l-kinurenic acid, quinolinic acid (QA) and picolinic acid (PA) have been shown physiologically important in central nervous and immune system, and various enzyme activities concerning their production were reported to...

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Veröffentlicht in:	European journal of nutrition 2009-04, Vol.48 (3), p.145-153
Hauptverfasser:	Sasaki, Naho, Egashira, Yukari, Sanada, Hiroo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Glucose - analysis Carboxy-Lyases - genetics Chemistry Chemistry and Materials Science Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - enzymology Diabetes Mellitus, Experimental - metabolism Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Hepatocytes - enzymology Hepatocytes - metabolism Kynurenine - biosynthesis Male Medical sciences Niacinamide - biosynthesis Nutrition Original Contribution Picolinic Acids - metabolism Quinolinic Acid - metabolism Rats Rats, Sprague-Dawley RNA, Messenger - analysis Tritium Tryptophan - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems Water - metabolism
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