Mechanisms for Macrophage-Mediated HIV-1 Induction

Viral latency is a long-term pathogenic condition in patients infected with HIV-1. Low but sustained virus replication in chronically infected cells can be activated by stimulation with proinflammatory cytokines such as TNF-alpha, IL-1 beta, or other host factors. However, the precise mechanism by w...

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Veröffentlicht in:	The Journal of immunology (1950) 2004-12, Vol.173 (11), p.6735-6744
Hauptverfasser:	Devadas, Krishnakumar, Hardegen, Neil J, Wahl, Larry M, Hewlett, Indira K, Clouse, Kathleen A, Yamada, Kenneth M, Dhawan, Subhash
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Communication - immunology Cell Line Coculture Techniques Cytokines - biosynthesis HIV-1 - immunology HIV-1 - physiology Human immunodeficiency virus 1 Humans Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - virology Macrophages - immunology Macrophages - metabolism Macrophages - virology Monocytes - immunology Monocytes - virology NF-kappa B - antagonists & inhibitors NF-kappa B - biosynthesis Nitriles - pharmacology Sulfones - pharmacology Tumor Necrosis Factor-alpha - physiology U937 Cells Virus Activation - immunology Virus Latency - immunology Virus Replication - immunology
Online-Zugang:	Volltext
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