Presence of Diabetes-Inhibiting, Glutamic Acid Decarboxylase-Specific, IL-10-Dependent, Regulatory T Cells in Naive Nonobese Diabetic Mice

Immunization of NOD mice with autoantigens such as glutamic acid decarboxylase (GAD) 221-235 peptide (p221) can induce Ag-specific CD4(+) T regulatory (Tr) cells. However, it is unclear whether these Tr cells acquire their regulatory capacity due to immunization or whether they are constitutively ha...

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Veröffentlicht in:	The Journal of immunology (1950) 2004-12, Vol.173 (11), p.6777-6785
Hauptverfasser:	You, Sylvaine, Chen, Cyndi, Lee, Wen-Hui, Brusko, Todd, Atkinson, Mark, Liu, Chih-Pin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals CD4-Positive T-Lymphocytes - enzymology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - transplantation Cell Separation - methods Cytokines - metabolism Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - prevention & control Epitopes, T-Lymphocyte - biosynthesis Epitopes, T-Lymphocyte - immunology Female Glutamate Decarboxylase - biosynthesis Glutamate Decarboxylase - immunology Immunodominant Epitopes - biosynthesis Immunodominant Epitopes - immunology Interleukin-10 - physiology Mice Mice, Inbred NOD Mice, SCID Peptide Fragments - biosynthesis Peptide Fragments - immunology Prediabetic State - immunology Prediabetic State - prevention & control Spleen - cytology Spleen - enzymology Spleen - immunology Spleen - transplantation T-Lymphocyte Subsets - enzymology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - transplantation
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