Human Pax-5 C-terminal Isoforms Possess Distinct Transactivation Properties and Are Differentially Modulated in Normal and Malignant B Cells

The transcription factor Pax-5 occupies a central role in B cell differentiation and has been implicated in the development of B cell lymphoma. The transcriptional activation function of Pax-5 requires an intact N-terminal DNA-binding domain and is strongly influenced by the C-terminal transactivati...

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Veröffentlicht in:	The Journal of biological chemistry 2004-11, Vol.279 (48), p.49956-49963
Hauptverfasser:	Robichaud, Gilles A., Nardini, Michel, Laflamme, Mark, Cuperlovic-Culf, Miroslava, Ouellette, Rodney J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing - genetics B-Lymphocytes - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Regulation, Neoplastic - physiology Humans Leukemia, B-Cell - metabolism Molecular Sequence Data PAX5 Transcription Factor Protein Isoforms - genetics Protein Isoforms - metabolism Transcription Factors - genetics Transcription Factors - metabolism Transcriptional Activation
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