Usefulness of the prognostic score for donor safety in living donor liver transplantation
This study sought to determine whether a prognostic score is a useful indicator of donor safety using 13 consecutive donors enrolled for liver transplantation. The donor operations were right hepatic lobectomies ( n = 10) and left hepatic lobectomies ( n = 3). The postoperative maximal level of seru...
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| Veröffentlicht in: | Transplantation proceedings 2004-10, Vol.36 (8), p.2219-2221 |
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| creator | Sekido, H. Matsuo, K. Takeda, K. Sugita, M. Morioka, D. Kubota, T. Tanaka, K. Endo, I. Togo, S. Shimada, H. |
| description | This study sought to determine whether a prognostic score is a useful indicator of donor safety using 13 consecutive donors enrolled for liver transplantation. The donor operations were right hepatic lobectomies (
n = 10) and left hepatic lobectomies (
n = 3). The postoperative maximal level of serum total bilirubin was used to assess the magnitude of surgical stress. Variables such as donor age, percentage of liver resection (PLR), indocyanine green 15-minute retention rate (ICGR15), operative blood loss, operation time, prognostic score and graft weight were evaluated as predictors of the magnitude of surgical stress. The PLR and prognostic score (PS) were calculated according to the following formulae: PLR (%) = 100*Graft weight (g)/standard liver volume of the donor (mL); PS = −84.6 + 0.933*PLR (%) +1.11*ICGR15 (%) +0.999*age (years); Standard liver volume (mL) = 706.2*body surface area (m
2) + 2.39. No serious complications occurred after the donor operations. Maximal bilirubin ranged from 1.9 to 10.9 mg/dL. There were no mortalities, although there were two morbidities, bile leakage and prolonged liver dysfunction. Postoperative hyperbilirubinemia was observed in two donors and in one Gilbert's syndrome donor. Linear regression analysis of each variable indicated poor correlations between those variables and maximal bilirubin. However, close correlations were seen between maximal bilirubin and both donor age and PS except for the three patients who showed postoperative hyperbilirubinemia. In these uneventful donors, statistical formulae were obtained as follows: maximal bilirubin (PMB) = 0.271 + 0.056*donor age (correlation coefficient 0.612,
P < .008), PMB = 1.541 + 0.059*PS (correlation coefficient 0.597,
P < .009). In conclusion, PS is useful to predict maximal bilirubin and to ensure donor safety. |
| doi_str_mv | 10.1016/j.transproceed.2004.06.041 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67098871</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0041134504007225</els_id><sourcerecordid>67098871</sourcerecordid><originalsourceid>FETCH-LOGICAL-c406t-1eb8651ceb1b6d74a657125e98fc38c5b05db7ff075be546f1b79db156c189183</originalsourceid><addsrcrecordid>eNqNkE9v1DAQxS0EokvhKyALCW4JniR2Em6o_JUqcaEHTpbtjItXWbt4vJX67fFqI-DIZUbjefP89GPsFYgWBKi3-7ZkE-kuJ4e4tJ0QQytUKwZ4xHYwjX3Tqa5_zHZ1AQ30g7xgz4j2os7d0D9lFyClApjVjv24IfTHNSIRT56Xn8ir721MVILj5FJG7lPmS4q1kvFYHniIfA33Id5uz3XAzM-hVhOLKSHF5-yJNyvhi61fsptPH79ffWmuv33-evX-unGDUKUBtJOS4NCCVcs4GCVH6CTOk3f95KQVcrGj92KUFuWgPNhxXixI5WCaYeov2Zuzb83964hU9CGQw7UGwXQkrUYxT9MIVfjuLHQ5EWX0-i6Hg8kPGoQ-gdV7_S9YfQKrhdKVYj1-uf1ytIe6-3O6kayC15vAkDOrr0Yu0F-d6rtO9SejD2cdVib3AbMmFzA6XEJGV_SSwv_k-Q13AJ9b</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67098871</pqid></control><display><type>article</type><title>Usefulness of the prognostic score for donor safety in living donor liver transplantation</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Sekido, H. ; Matsuo, K. ; Takeda, K. ; Sugita, M. ; Morioka, D. ; Kubota, T. ; Tanaka, K. ; Endo, I. ; Togo, S. ; Shimada, H.</creator><creatorcontrib>Sekido, H. ; Matsuo, K. ; Takeda, K. ; Sugita, M. ; Morioka, D. ; Kubota, T. ; Tanaka, K. ; Endo, I. ; Togo, S. ; Shimada, H.</creatorcontrib><description>This study sought to determine whether a prognostic score is a useful indicator of donor safety using 13 consecutive donors enrolled for liver transplantation. The donor operations were right hepatic lobectomies (
n = 10) and left hepatic lobectomies (
n = 3). The postoperative maximal level of serum total bilirubin was used to assess the magnitude of surgical stress. Variables such as donor age, percentage of liver resection (PLR), indocyanine green 15-minute retention rate (ICGR15), operative blood loss, operation time, prognostic score and graft weight were evaluated as predictors of the magnitude of surgical stress. The PLR and prognostic score (PS) were calculated according to the following formulae: PLR (%) = 100*Graft weight (g)/standard liver volume of the donor (mL); PS = −84.6 + 0.933*PLR (%) +1.11*ICGR15 (%) +0.999*age (years); Standard liver volume (mL) = 706.2*body surface area (m
2) + 2.39. No serious complications occurred after the donor operations. Maximal bilirubin ranged from 1.9 to 10.9 mg/dL. There were no mortalities, although there were two morbidities, bile leakage and prolonged liver dysfunction. Postoperative hyperbilirubinemia was observed in two donors and in one Gilbert's syndrome donor. Linear regression analysis of each variable indicated poor correlations between those variables and maximal bilirubin. However, close correlations were seen between maximal bilirubin and both donor age and PS except for the three patients who showed postoperative hyperbilirubinemia. In these uneventful donors, statistical formulae were obtained as follows: maximal bilirubin (PMB) = 0.271 + 0.056*donor age (correlation coefficient 0.612,
P < .008), PMB = 1.541 + 0.059*PS (correlation coefficient 0.597,
P < .009). In conclusion, PS is useful to predict maximal bilirubin and to ensure donor safety.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2004.06.041</identifier><identifier>PMID: 15561196</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Age Factors ; Biological and medical sciences ; Blood Loss, Surgical ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Gilbert Disease - surgery ; Humans ; Liver Transplantation - physiology ; Living Donors - statistics & numerical data ; Medical sciences ; Organ Size ; Prognosis ; Safety ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tissue, organ and graft immunology ; Treatment Outcome</subject><ispartof>Transplantation proceedings, 2004-10, Vol.36 (8), p.2219-2221</ispartof><rights>2004 Elsevier Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-1eb8651ceb1b6d74a657125e98fc38c5b05db7ff075be546f1b79db156c189183</citedby><cites>FETCH-LOGICAL-c406t-1eb8651ceb1b6d74a657125e98fc38c5b05db7ff075be546f1b79db156c189183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.transproceed.2004.06.041$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>310,311,315,781,785,790,791,3551,23935,23936,25145,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16322631$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15561196$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sekido, H.</creatorcontrib><creatorcontrib>Matsuo, K.</creatorcontrib><creatorcontrib>Takeda, K.</creatorcontrib><creatorcontrib>Sugita, M.</creatorcontrib><creatorcontrib>Morioka, D.</creatorcontrib><creatorcontrib>Kubota, T.</creatorcontrib><creatorcontrib>Tanaka, K.</creatorcontrib><creatorcontrib>Endo, I.</creatorcontrib><creatorcontrib>Togo, S.</creatorcontrib><creatorcontrib>Shimada, H.</creatorcontrib><title>Usefulness of the prognostic score for donor safety in living donor liver transplantation</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>This study sought to determine whether a prognostic score is a useful indicator of donor safety using 13 consecutive donors enrolled for liver transplantation. The donor operations were right hepatic lobectomies (
n = 10) and left hepatic lobectomies (
n = 3). The postoperative maximal level of serum total bilirubin was used to assess the magnitude of surgical stress. Variables such as donor age, percentage of liver resection (PLR), indocyanine green 15-minute retention rate (ICGR15), operative blood loss, operation time, prognostic score and graft weight were evaluated as predictors of the magnitude of surgical stress. The PLR and prognostic score (PS) were calculated according to the following formulae: PLR (%) = 100*Graft weight (g)/standard liver volume of the donor (mL); PS = −84.6 + 0.933*PLR (%) +1.11*ICGR15 (%) +0.999*age (years); Standard liver volume (mL) = 706.2*body surface area (m
2) + 2.39. No serious complications occurred after the donor operations. Maximal bilirubin ranged from 1.9 to 10.9 mg/dL. There were no mortalities, although there were two morbidities, bile leakage and prolonged liver dysfunction. Postoperative hyperbilirubinemia was observed in two donors and in one Gilbert's syndrome donor. Linear regression analysis of each variable indicated poor correlations between those variables and maximal bilirubin. However, close correlations were seen between maximal bilirubin and both donor age and PS except for the three patients who showed postoperative hyperbilirubinemia. In these uneventful donors, statistical formulae were obtained as follows: maximal bilirubin (PMB) = 0.271 + 0.056*donor age (correlation coefficient 0.612,
P < .008), PMB = 1.541 + 0.059*PS (correlation coefficient 0.597,
P < .009). In conclusion, PS is useful to predict maximal bilirubin and to ensure donor safety.</description><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Blood Loss, Surgical</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Gilbert Disease - surgery</subject><subject>Humans</subject><subject>Liver Transplantation - physiology</subject><subject>Living Donors - statistics & numerical data</subject><subject>Medical sciences</subject><subject>Organ Size</subject><subject>Prognosis</subject><subject>Safety</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Tissue, organ and graft immunology</subject><subject>Treatment Outcome</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE9v1DAQxS0EokvhKyALCW4JniR2Em6o_JUqcaEHTpbtjItXWbt4vJX67fFqI-DIZUbjefP89GPsFYgWBKi3-7ZkE-kuJ4e4tJ0QQytUKwZ4xHYwjX3Tqa5_zHZ1AQ30g7xgz4j2os7d0D9lFyClApjVjv24IfTHNSIRT56Xn8ir721MVILj5FJG7lPmS4q1kvFYHniIfA33Id5uz3XAzM-hVhOLKSHF5-yJNyvhi61fsptPH79ffWmuv33-evX-unGDUKUBtJOS4NCCVcs4GCVH6CTOk3f95KQVcrGj92KUFuWgPNhxXixI5WCaYeov2Zuzb83964hU9CGQw7UGwXQkrUYxT9MIVfjuLHQ5EWX0-i6Hg8kPGoQ-gdV7_S9YfQKrhdKVYj1-uf1ytIe6-3O6kayC15vAkDOrr0Yu0F-d6rtO9SejD2cdVib3AbMmFzA6XEJGV_SSwv_k-Q13AJ9b</recordid><startdate>20041001</startdate><enddate>20041001</enddate><creator>Sekido, H.</creator><creator>Matsuo, K.</creator><creator>Takeda, K.</creator><creator>Sugita, M.</creator><creator>Morioka, D.</creator><creator>Kubota, T.</creator><creator>Tanaka, K.</creator><creator>Endo, I.</creator><creator>Togo, S.</creator><creator>Shimada, H.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041001</creationdate><title>Usefulness of the prognostic score for donor safety in living donor liver transplantation</title><author>Sekido, H. ; Matsuo, K. ; Takeda, K. ; Sugita, M. ; Morioka, D. ; Kubota, T. ; Tanaka, K. ; Endo, I. ; Togo, S. ; Shimada, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-1eb8651ceb1b6d74a657125e98fc38c5b05db7ff075be546f1b79db156c189183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Blood Loss, Surgical</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Gilbert Disease - surgery</topic><topic>Humans</topic><topic>Liver Transplantation - physiology</topic><topic>Living Donors - statistics & numerical data</topic><topic>Medical sciences</topic><topic>Organ Size</topic><topic>Prognosis</topic><topic>Safety</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Tissue, organ and graft immunology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sekido, H.</creatorcontrib><creatorcontrib>Matsuo, K.</creatorcontrib><creatorcontrib>Takeda, K.</creatorcontrib><creatorcontrib>Sugita, M.</creatorcontrib><creatorcontrib>Morioka, D.</creatorcontrib><creatorcontrib>Kubota, T.</creatorcontrib><creatorcontrib>Tanaka, K.</creatorcontrib><creatorcontrib>Endo, I.</creatorcontrib><creatorcontrib>Togo, S.</creatorcontrib><creatorcontrib>Shimada, H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sekido, H.</au><au>Matsuo, K.</au><au>Takeda, K.</au><au>Sugita, M.</au><au>Morioka, D.</au><au>Kubota, T.</au><au>Tanaka, K.</au><au>Endo, I.</au><au>Togo, S.</au><au>Shimada, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Usefulness of the prognostic score for donor safety in living donor liver transplantation</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2004-10-01</date><risdate>2004</risdate><volume>36</volume><issue>8</issue><spage>2219</spage><epage>2221</epage><pages>2219-2221</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>This study sought to determine whether a prognostic score is a useful indicator of donor safety using 13 consecutive donors enrolled for liver transplantation. The donor operations were right hepatic lobectomies (
n = 10) and left hepatic lobectomies (
n = 3). The postoperative maximal level of serum total bilirubin was used to assess the magnitude of surgical stress. Variables such as donor age, percentage of liver resection (PLR), indocyanine green 15-minute retention rate (ICGR15), operative blood loss, operation time, prognostic score and graft weight were evaluated as predictors of the magnitude of surgical stress. The PLR and prognostic score (PS) were calculated according to the following formulae: PLR (%) = 100*Graft weight (g)/standard liver volume of the donor (mL); PS = −84.6 + 0.933*PLR (%) +1.11*ICGR15 (%) +0.999*age (years); Standard liver volume (mL) = 706.2*body surface area (m
2) + 2.39. No serious complications occurred after the donor operations. Maximal bilirubin ranged from 1.9 to 10.9 mg/dL. There were no mortalities, although there were two morbidities, bile leakage and prolonged liver dysfunction. Postoperative hyperbilirubinemia was observed in two donors and in one Gilbert's syndrome donor. Linear regression analysis of each variable indicated poor correlations between those variables and maximal bilirubin. However, close correlations were seen between maximal bilirubin and both donor age and PS except for the three patients who showed postoperative hyperbilirubinemia. In these uneventful donors, statistical formulae were obtained as follows: maximal bilirubin (PMB) = 0.271 + 0.056*donor age (correlation coefficient 0.612,
P < .008), PMB = 1.541 + 0.059*PS (correlation coefficient 0.597,
P < .009). In conclusion, PS is useful to predict maximal bilirubin and to ensure donor safety.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15561196</pmid><doi>10.1016/j.transproceed.2004.06.041</doi><tpages>3</tpages></addata></record> |
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| subjects | Age Factors Biological and medical sciences Blood Loss, Surgical Fundamental and applied biological sciences. Psychology Fundamental immunology Gilbert Disease - surgery Humans Liver Transplantation - physiology Living Donors - statistics & numerical data Medical sciences Organ Size Prognosis Safety Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue, organ and graft immunology Treatment Outcome |
| title | Usefulness of the prognostic score for donor safety in living donor liver transplantation |
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