Association of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers
Background/Objectives: There are other benefits of vitamin D than those for bone health. To determine the association of serum 25-hydroxy vitamin D (25(OH)D) concentrations in newborns with acute lower respiratory infection (ALRI) and without clinical signs of rickets, and their mothers. The design...
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| Veröffentlicht in: | European journal of clinical nutrition 2009-04, Vol.63 (4), p.473-477 |
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| creator | Karatekin, G Kaya, A Salihoglu, O Balci, H Nuhoglu, A |
| description | Background/Objectives: There are other benefits of vitamin D than those for bone health. To determine the association of serum 25-hydroxy vitamin D (25(OH)D) concentrations in newborns with acute lower respiratory infection (ALRI) and without clinical signs of rickets, and their mothers. The design comprises a hospital-based case-control study. Subjects/Methods: The study group consisted of 25 newborns with ALRI who were admitted to neonatal intensive care unit and their mothers. Controls were 15 healthy newborns of the same age as the study group and their mothers. A commercial radioimmunoassay was used to measure 25(OH)D concentrations in serum for assessing vitamin D status. Results: The two groups were similar in gestational week, birth weight, birth height, head circumference, age and gender. The mean serum 25(OH)D concentrations in the study group newborns were lower than those of the control group (9.128.88ng/ml and 16.3313.42 ng/ml, respectively) (P=0.011). Also, mean serum 25(OH)D concentrations in the mothers of the study group were lower than those in the mothers of the control group (13.3816.81 ng/ml and 22.7916.93 ng/ml respectively) (P=0.012). In 87.5% of all newborns and 67.5% of all mothers, serum 25(OH)D concentrations were lower than 20 ng/ml. The 25(OH)D concentrations of newborns were highly correlated with mothers' serum 25(OH)D concentrations. Conclusions: Our findings suggest that newborns with subclinical vitamin D deficiency may have an increased risk of suffering from ALRI. The strong positive correlation between newborns' and mothers' 25(OH)D concentrations shows that adequate vitamin D supplementation of mothers should be emphasized during pregnancy especially in winter months. |
| doi_str_mv | 10.1038/sj.ejcn.1602960 |
| format | Article |
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To determine the association of serum 25-hydroxy vitamin D (25(OH)D) concentrations in newborns with acute lower respiratory infection (ALRI) and without clinical signs of rickets, and their mothers. The design comprises a hospital-based case-control study. Subjects/Methods: The study group consisted of 25 newborns with ALRI who were admitted to neonatal intensive care unit and their mothers. Controls were 15 healthy newborns of the same age as the study group and their mothers. A commercial radioimmunoassay was used to measure 25(OH)D concentrations in serum for assessing vitamin D status. Results: The two groups were similar in gestational week, birth weight, birth height, head circumference, age and gender. The mean serum 25(OH)D concentrations in the study group newborns were lower than those of the control group (9.128.88ng/ml and 16.3313.42 ng/ml, respectively) (P=0.011). Also, mean serum 25(OH)D concentrations in the mothers of the study group were lower than those in the mothers of the control group (13.3816.81 ng/ml and 22.7916.93 ng/ml respectively) (P=0.012). In 87.5% of all newborns and 67.5% of all mothers, serum 25(OH)D concentrations were lower than 20 ng/ml. The 25(OH)D concentrations of newborns were highly correlated with mothers' serum 25(OH)D concentrations. Conclusions: Our findings suggest that newborns with subclinical vitamin D deficiency may have an increased risk of suffering from ALRI. The strong positive correlation between newborns' and mothers' 25(OH)D concentrations shows that adequate vitamin D supplementation of mothers should be emphasized during pregnancy especially in winter months.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/sj.ejcn.1602960</identifier><identifier>PMID: 18030309</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>25-hydroxyergocalciferol ; acute course ; Adult ; Babies ; Biological and medical sciences ; Birth weight ; Calciferol ; Case studies ; Case-Control Studies ; Clinical Nutrition ; Complications and side effects ; Dietary supplements ; disease severity ; Educational Status ; Epidemiology ; Feeding. Feeding behavior ; Female ; Food and nutrition ; Fundamental and applied biological sciences. Psychology ; Health aspects ; human nutrition ; Humans ; Infant, Newborn ; infants ; Infants (Newborn) ; Internal Medicine ; Male ; Maternal & child health ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; mothers ; Neonates ; original-article ; Parents ; Pregnancy ; Public Health ; Radioimmunoassay ; radioimmunoassays ; Reference Values ; Respiratory diseases ; respiratory tract diseases ; Respiratory tract infection ; Respiratory tract infections ; Respiratory Tract Infections - blood ; Respiratory Tract Infections - complications ; Rickets ; Risk factors ; subclinical vitamin deficiency ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D deficiency ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - complications ; vitamin deficiencies ; Vitamin deficiency ; vitamin supplements ; Vitamins - blood</subject><ispartof>European journal of clinical nutrition, 2009-04, Vol.63 (4), p.473-477</ispartof><rights>Springer Nature Limited 2009</rights><rights>2009 INIST-CNRS</rights><rights>COPYRIGHT 2009 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Apr 2009</rights><rights>Nature Publishing Group 2009.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-cef59421958c1f9f6d27e9fbbbd5134126740783155b4f1ad62b61b8b8aa1f0d3</citedby><cites>FETCH-LOGICAL-c517t-cef59421958c1f9f6d27e9fbbbd5134126740783155b4f1ad62b61b8b8aa1f0d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.ejcn.1602960$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.ejcn.1602960$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21266339$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18030309$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karatekin, G</creatorcontrib><creatorcontrib>Kaya, A</creatorcontrib><creatorcontrib>Salihoglu, O</creatorcontrib><creatorcontrib>Balci, H</creatorcontrib><creatorcontrib>Nuhoglu, A</creatorcontrib><title>Association of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Background/Objectives: There are other benefits of vitamin D than those for bone health. To determine the association of serum 25-hydroxy vitamin D (25(OH)D) concentrations in newborns with acute lower respiratory infection (ALRI) and without clinical signs of rickets, and their mothers. The design comprises a hospital-based case-control study. Subjects/Methods: The study group consisted of 25 newborns with ALRI who were admitted to neonatal intensive care unit and their mothers. Controls were 15 healthy newborns of the same age as the study group and their mothers. A commercial radioimmunoassay was used to measure 25(OH)D concentrations in serum for assessing vitamin D status. Results: The two groups were similar in gestational week, birth weight, birth height, head circumference, age and gender. The mean serum 25(OH)D concentrations in the study group newborns were lower than those of the control group (9.128.88ng/ml and 16.3313.42 ng/ml, respectively) (P=0.011). Also, mean serum 25(OH)D concentrations in the mothers of the study group were lower than those in the mothers of the control group (13.3816.81 ng/ml and 22.7916.93 ng/ml respectively) (P=0.012). In 87.5% of all newborns and 67.5% of all mothers, serum 25(OH)D concentrations were lower than 20 ng/ml. The 25(OH)D concentrations of newborns were highly correlated with mothers' serum 25(OH)D concentrations. Conclusions: Our findings suggest that newborns with subclinical vitamin D deficiency may have an increased risk of suffering from ALRI. The strong positive correlation between newborns' and mothers' 25(OH)D concentrations shows that adequate vitamin D supplementation of mothers should be emphasized during pregnancy especially in winter months.</description><subject>25-hydroxyergocalciferol</subject><subject>acute course</subject><subject>Adult</subject><subject>Babies</subject><subject>Biological and medical sciences</subject><subject>Birth weight</subject><subject>Calciferol</subject><subject>Case studies</subject><subject>Case-Control Studies</subject><subject>Clinical Nutrition</subject><subject>Complications and side effects</subject><subject>Dietary supplements</subject><subject>disease severity</subject><subject>Educational Status</subject><subject>Epidemiology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Food and nutrition</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health aspects</subject><subject>human nutrition</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>infants</subject><subject>Infants (Newborn)</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Maternal & child health</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>mothers</subject><subject>Neonates</subject><subject>original-article</subject><subject>Parents</subject><subject>Pregnancy</subject><subject>Public Health</subject><subject>Radioimmunoassay</subject><subject>radioimmunoassays</subject><subject>Reference Values</subject><subject>Respiratory diseases</subject><subject>respiratory tract diseases</subject><subject>Respiratory tract infection</subject><subject>Respiratory tract infections</subject><subject>Respiratory Tract Infections - blood</subject><subject>Respiratory Tract Infections - complications</subject><subject>Rickets</subject><subject>Risk factors</subject><subject>subclinical vitamin deficiency</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D deficiency</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D Deficiency - complications</subject><subject>vitamin deficiencies</subject><subject>Vitamin deficiency</subject><subject>vitamin supplements</subject><subject>Vitamins - blood</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kd-LEzEQx4MoXq0--6ZB0bf2MsludvNYzp9w4IPec8hmkzZlm9TM7pX7701tsSAcCQzDfOY7yXwJeQ1sCUy017hduq2NS5CMK8mekBlUjVzUsmJPyYypuloIxpor8gJxy1gpNvw5uYKWiXLUjIwrxGSDGUOKNHmKU2eHEIM1A70Po9mFSD_R3vlgg4v2gZY8ukOXckR6COOGGjuNjg7p4DLNDvchmzHlI-id_StrYk_HjQuZ7lKJGV-SZ94M6F6d45zcffn86-bb4vbH1-83q9uFraEZF9b5WlUcVN1a8MrLnjdO-a7r-hpEBVw2FWtaAXXdVR5ML3knoWu71hjwrBdz8vGku8_p9-Rw1LuA1g2DiS5NqGXDlGylLOD7_8BtmnIsb9NcVlzWXJQ7J-8epUBJ2QquLjPXZnB648wwbjAN03ETqFegmlpBq6CA1yfQ5oSYndf7HHYmP2hg-miuxq0-mqvP5paON-f5U7dz_YU_u1mAD2fAYDHQZxNtwH8cLxuTQhw5duKwlOLa5ctHHp_99tTiTdJmnYvs3U_OQDCQ0Erg4g8v8scc</recordid><startdate>20090401</startdate><enddate>20090401</enddate><creator>Karatekin, G</creator><creator>Kaya, A</creator><creator>Salihoglu, O</creator><creator>Balci, H</creator><creator>Nuhoglu, A</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20090401</creationdate><title>Association of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers</title><author>Karatekin, G ; Kaya, A ; Salihoglu, O ; Balci, H ; Nuhoglu, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-cef59421958c1f9f6d27e9fbbbd5134126740783155b4f1ad62b61b8b8aa1f0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>25-hydroxyergocalciferol</topic><topic>acute course</topic><topic>Adult</topic><topic>Babies</topic><topic>Biological and medical sciences</topic><topic>Birth weight</topic><topic>Calciferol</topic><topic>Case studies</topic><topic>Case-Control Studies</topic><topic>Clinical Nutrition</topic><topic>Complications and side effects</topic><topic>Dietary supplements</topic><topic>disease severity</topic><topic>Educational Status</topic><topic>Epidemiology</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Food and nutrition</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Health aspects</topic><topic>human nutrition</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>infants</topic><topic>Infants (Newborn)</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Maternal & child health</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>mothers</topic><topic>Neonates</topic><topic>original-article</topic><topic>Parents</topic><topic>Pregnancy</topic><topic>Public Health</topic><topic>Radioimmunoassay</topic><topic>radioimmunoassays</topic><topic>Reference Values</topic><topic>Respiratory diseases</topic><topic>respiratory tract diseases</topic><topic>Respiratory tract infection</topic><topic>Respiratory tract infections</topic><topic>Respiratory Tract Infections - blood</topic><topic>Respiratory Tract Infections - complications</topic><topic>Rickets</topic><topic>Risk factors</topic><topic>subclinical vitamin deficiency</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamin D deficiency</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D Deficiency - complications</topic><topic>vitamin deficiencies</topic><topic>Vitamin deficiency</topic><topic>vitamin supplements</topic><topic>Vitamins - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karatekin, G</creatorcontrib><creatorcontrib>Kaya, A</creatorcontrib><creatorcontrib>Salihoglu, O</creatorcontrib><creatorcontrib>Balci, H</creatorcontrib><creatorcontrib>Nuhoglu, A</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karatekin, G</au><au>Kaya, A</au><au>Salihoglu, O</au><au>Balci, H</au><au>Nuhoglu, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2009-04-01</date><risdate>2009</risdate><volume>63</volume><issue>4</issue><spage>473</spage><epage>477</epage><pages>473-477</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>Background/Objectives: There are other benefits of vitamin D than those for bone health. To determine the association of serum 25-hydroxy vitamin D (25(OH)D) concentrations in newborns with acute lower respiratory infection (ALRI) and without clinical signs of rickets, and their mothers. The design comprises a hospital-based case-control study. Subjects/Methods: The study group consisted of 25 newborns with ALRI who were admitted to neonatal intensive care unit and their mothers. Controls were 15 healthy newborns of the same age as the study group and their mothers. A commercial radioimmunoassay was used to measure 25(OH)D concentrations in serum for assessing vitamin D status. Results: The two groups were similar in gestational week, birth weight, birth height, head circumference, age and gender. The mean serum 25(OH)D concentrations in the study group newborns were lower than those of the control group (9.128.88ng/ml and 16.3313.42 ng/ml, respectively) (P=0.011). Also, mean serum 25(OH)D concentrations in the mothers of the study group were lower than those in the mothers of the control group (13.3816.81 ng/ml and 22.7916.93 ng/ml respectively) (P=0.012). In 87.5% of all newborns and 67.5% of all mothers, serum 25(OH)D concentrations were lower than 20 ng/ml. The 25(OH)D concentrations of newborns were highly correlated with mothers' serum 25(OH)D concentrations. Conclusions: Our findings suggest that newborns with subclinical vitamin D deficiency may have an increased risk of suffering from ALRI. The strong positive correlation between newborns' and mothers' 25(OH)D concentrations shows that adequate vitamin D supplementation of mothers should be emphasized during pregnancy especially in winter months.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>18030309</pmid><doi>10.1038/sj.ejcn.1602960</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 25-hydroxyergocalciferol acute course Adult Babies Biological and medical sciences Birth weight Calciferol Case studies Case-Control Studies Clinical Nutrition Complications and side effects Dietary supplements disease severity Educational Status Epidemiology Feeding. Feeding behavior Female Food and nutrition Fundamental and applied biological sciences. Psychology Health aspects human nutrition Humans Infant, Newborn infants Infants (Newborn) Internal Medicine Male Maternal & child health Medical sciences Medicine Medicine & Public Health Metabolic Diseases mothers Neonates original-article Parents Pregnancy Public Health Radioimmunoassay radioimmunoassays Reference Values Respiratory diseases respiratory tract diseases Respiratory tract infection Respiratory tract infections Respiratory Tract Infections - blood Respiratory Tract Infections - complications Rickets Risk factors subclinical vitamin deficiency Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D deficiency Vitamin D Deficiency - blood Vitamin D Deficiency - complications vitamin deficiencies Vitamin deficiency vitamin supplements Vitamins - blood |
| title | Association of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers |
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