Emerging roles of RNA and RNA-binding protein network in cancer cells
Recent advances in RNA biology reveal unexpected diversity and complexity of cellular RNA metabolism. RNA-binding proteins (RBPs) are essential players in RNA metabolism, regulating RNA splicing, transport, surveillance, decay and translation. Aberrant expression of RBPs affects many steps of RNA me...
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| Veröffentlicht in: | BMB reports 2009-03, Vol.42 (3), p.125-130 |
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| creator | Kim, M.Y. (Dankook University, Cheonan, Republic of Korea) Hur, J. (Dankook University, Cheonan, Republic of Korea) Jeong, S.J. (Dankook University, Cheonan, Republic of Korea), E-mail: sjsj@dankook.ac.kr |
| description | Recent advances in RNA biology reveal unexpected diversity and complexity of cellular RNA metabolism. RNA-binding proteins (RBPs) are essential players in RNA metabolism, regulating RNA splicing, transport, surveillance, decay and translation. Aberrant expression of RBPs affects many steps of RNA metabolism, significantly altering expression of RNA. Thus, altered expression and dysfuncting of RBPs are implicated in the development of various diseases including cancer. In this minireview, we briefly describe emerging roles of RBPs as a global coordinator of post-transcriptional steps and altered RBPs as a global generator of cancer related RNA alternative splicing. Identification and characterization of the RNA-RBP network would expand the scope of cellular RNA metabolism and provide novel anti-cancer therapeutic targets based on cancer specific RNA-RBP interaction. |
| doi_str_mv | 10.5483/bmbrep.2009.42.3.125 |
| format | Article |
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(Dankook University, Cheonan, Republic of Korea) ; Hur, J. (Dankook University, Cheonan, Republic of Korea) ; Jeong, S.J. (Dankook University, Cheonan, Republic of Korea), E-mail: sjsj@dankook.ac.kr</creator><creatorcontrib>Kim, M.Y. (Dankook University, Cheonan, Republic of Korea) ; Hur, J. (Dankook University, Cheonan, Republic of Korea) ; Jeong, S.J. (Dankook University, Cheonan, Republic of Korea), E-mail: sjsj@dankook.ac.kr</creatorcontrib><description>Recent advances in RNA biology reveal unexpected diversity and complexity of cellular RNA metabolism. RNA-binding proteins (RBPs) are essential players in RNA metabolism, regulating RNA splicing, transport, surveillance, decay and translation. Aberrant expression of RBPs affects many steps of RNA metabolism, significantly altering expression of RNA. Thus, altered expression and dysfuncting of RBPs are implicated in the development of various diseases including cancer. In this minireview, we briefly describe emerging roles of RBPs as a global coordinator of post-transcriptional steps and altered RBPs as a global generator of cancer related RNA alternative splicing. 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In this minireview, we briefly describe emerging roles of RBPs as a global coordinator of post-transcriptional steps and altered RBPs as a global generator of cancer related RNA alternative splicing. Identification and characterization of the RNA-RBP network would expand the scope of cellular RNA metabolism and provide novel anti-cancer therapeutic targets based on cancer specific RNA-RBP interaction.</description><subject>Alternative Splicing</subject><subject>Animals</subject><subject>ARN</subject><subject>Cancer</subject><subject>Humans</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>RNA</subject><subject>RNA metabolism</subject><subject>RNA, Neoplasm - genetics</subject><subject>RNA, Neoplasm - metabolism</subject><subject>RNA-binding protein (RBP)</subject><subject>RNA-Binding Proteins - metabolism</subject><issn>1976-6696</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtPwzAQhH0A0VL4B4By4pawfiSOj21VHqKAVMHZcpx1FWge2KkQ_55ErcRpV7vfjEZDyBWFJBU5vyvqwmOXMACVCJbwhLL0hEypklmcZSqbkPMQPgEyyiQ7IxOqOE-VklOyWtXot1WzjXy7wxC1Ltq8ziPTlOOMi6opx2fn2x6rJmqw_2n9VzSs1jQWfWRxtwsX5NSZXcDL45yRj_vV-_IxXr89PC3n69gKBX2cplwxSIGB43kphOJoHBhj0OW5pTwD4YaDAFoyZyVYaRUtrEqZQSOx4DNye_Ad8nzvMfS6rsKYwDTY7oPOJKhMcBhAcQCtb0Pw6HTnq9r4X01Bj5Xpxctig50eK9OCaa6HygbZzdF_X9RY_ouOfQ3A9QFwptVm66ugnzejB4DgkvE_oVZysA</recordid><startdate>20090331</startdate><enddate>20090331</enddate><creator>Kim, M.Y. 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| source | MEDLINE; DOAJ Directory of Open Access Journals; Free Full-Text Journals in Chemistry |
| subjects | Alternative Splicing Animals ARN Cancer Humans Neoplasms - metabolism Neoplasms - pathology RNA RNA metabolism RNA, Neoplasm - genetics RNA, Neoplasm - metabolism RNA-binding protein (RBP) RNA-Binding Proteins - metabolism |
| title | Emerging roles of RNA and RNA-binding protein network in cancer cells |
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