Cardiovascular response to mental and physical stress in hyper-reactive normotensive subjects. Beta blockade effect
The aim of our study was to evaluate the cardiovascular reactivity in healthy normotensive subjects without medication, using mental and physical stress techniques: Stroop color word conflict test (SCWCT), anticipatory blood pressure response to exercise (ARE) and stress testing (ST). We analized th...
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| Veröffentlicht in: | Medicina (Buenos Aires) 2004, Vol.64 (5), p.390-394 |
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| creator | Przybylski, Julio Resnik, Miguel Corsi, Miriam Suez, Victor Dervich, Roberto Bevacqua, Raul Lachitiello, Jorge Elizari, Marcelo |
| description | The aim of our study was to evaluate the cardiovascular reactivity in healthy normotensive subjects without medication, using mental and physical stress techniques: Stroop color word conflict test (SCWCT), anticipatory blood pressure response to exercise (ARE) and stress testing (ST). We analized the effects of a selective beta 1 betablocker: bisoprolol (B) on cardiovascular reactivity in our subjects (s). We studied 42 s, but only 30 (21 females and 9 males) were included who were hyperreactives. The mean age was 42.5 years. The higher values of systolic (SBP) and diastolic blood pressure (DBP) during the mental stress (MS) were taken as a measure of reactivity considering hyperreactive response an increase of 30 mm Hg or more and/or 15 mm Hg or more respectively. A prospective, randomized and double blind study on the effects of an oral daily doses of B (5 mg) vs placebo (P) was performed. Statistical analysis was realized with the Fisher exact test. In the results, we could observed a lower sensitivity of ARE and ST vs SCWCT. The 15 s who recieved P followed hyperreactives but 6 of 15 s treated with B were non reactives (p |
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Beta blockade effect</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Przybylski, Julio ; Resnik, Miguel ; Corsi, Miriam ; Suez, Victor ; Dervich, Roberto ; Bevacqua, Raul ; Lachitiello, Jorge ; Elizari, Marcelo</creator><creatorcontrib>Przybylski, Julio ; Resnik, Miguel ; Corsi, Miriam ; Suez, Victor ; Dervich, Roberto ; Bevacqua, Raul ; Lachitiello, Jorge ; Elizari, Marcelo</creatorcontrib><description>The aim of our study was to evaluate the cardiovascular reactivity in healthy normotensive subjects without medication, using mental and physical stress techniques: Stroop color word conflict test (SCWCT), anticipatory blood pressure response to exercise (ARE) and stress testing (ST). We analized the effects of a selective beta 1 betablocker: bisoprolol (B) on cardiovascular reactivity in our subjects (s). We studied 42 s, but only 30 (21 females and 9 males) were included who were hyperreactives. The mean age was 42.5 years. The higher values of systolic (SBP) and diastolic blood pressure (DBP) during the mental stress (MS) were taken as a measure of reactivity considering hyperreactive response an increase of 30 mm Hg or more and/or 15 mm Hg or more respectively. A prospective, randomized and double blind study on the effects of an oral daily doses of B (5 mg) vs placebo (P) was performed. Statistical analysis was realized with the Fisher exact test. In the results, we could observed a lower sensitivity of ARE and ST vs SCWCT. The 15 s who recieved P followed hyperreactives but 6 of 15 s treated with B were non reactives (p<0.017). B showed a beneficial effect on the hyperreactivity in a significant number of s in relation with P and it could be useful for the prevention of a future hypertension.</description><identifier>ISSN: 0025-7680</identifier><identifier>PMID: 15560538</identifier><language>spa</language><publisher>Argentina</publisher><subject>Adrenergic beta-Antagonists - pharmacology ; Adult ; Bisoprolol - pharmacology ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Cardiovascular System - drug effects ; Double-Blind Method ; Exercise Test ; Female ; Heart Rate - drug effects ; Heart Rate - physiology ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Prospective Studies ; Stress, Psychological - physiopathology</subject><ispartof>Medicina (Buenos Aires), 2004, Vol.64 (5), p.390-394</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4021</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15560538$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Przybylski, Julio</creatorcontrib><creatorcontrib>Resnik, Miguel</creatorcontrib><creatorcontrib>Corsi, Miriam</creatorcontrib><creatorcontrib>Suez, Victor</creatorcontrib><creatorcontrib>Dervich, Roberto</creatorcontrib><creatorcontrib>Bevacqua, Raul</creatorcontrib><creatorcontrib>Lachitiello, Jorge</creatorcontrib><creatorcontrib>Elizari, Marcelo</creatorcontrib><title>Cardiovascular response to mental and physical stress in hyper-reactive normotensive subjects. Beta blockade effect</title><title>Medicina (Buenos Aires)</title><addtitle>Medicina (B Aires)</addtitle><description>The aim of our study was to evaluate the cardiovascular reactivity in healthy normotensive subjects without medication, using mental and physical stress techniques: Stroop color word conflict test (SCWCT), anticipatory blood pressure response to exercise (ARE) and stress testing (ST). We analized the effects of a selective beta 1 betablocker: bisoprolol (B) on cardiovascular reactivity in our subjects (s). We studied 42 s, but only 30 (21 females and 9 males) were included who were hyperreactives. The mean age was 42.5 years. The higher values of systolic (SBP) and diastolic blood pressure (DBP) during the mental stress (MS) were taken as a measure of reactivity considering hyperreactive response an increase of 30 mm Hg or more and/or 15 mm Hg or more respectively. A prospective, randomized and double blind study on the effects of an oral daily doses of B (5 mg) vs placebo (P) was performed. Statistical analysis was realized with the Fisher exact test. In the results, we could observed a lower sensitivity of ARE and ST vs SCWCT. The 15 s who recieved P followed hyperreactives but 6 of 15 s treated with B were non reactives (p<0.017). B showed a beneficial effect on the hyperreactivity in a significant number of s in relation with P and it could be useful for the prevention of a future hypertension.</description><subject>Adrenergic beta-Antagonists - pharmacology</subject><subject>Adult</subject><subject>Bisoprolol - pharmacology</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure - physiology</subject><subject>Cardiovascular System - drug effects</subject><subject>Double-Blind Method</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Heart Rate - drug effects</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Prospective Studies</subject><subject>Stress, Psychological - physiopathology</subject><issn>0025-7680</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kMtOwzAURL0A0VL4BeQVuyDnYTteQsVLqsQG1tGNfaOmJHbwdSr17wkCVqMzOprFnLG1EIXMtKrFil0SHYQojTbqgq1yKZWQZb1mtIXo-nAEsvMAkUekKXhCngIf0ScYOHjHp_2JersApcUg3nu-P00Ys4hgU39E7kMcQ0JPP0Bze0Cb6I4_YALeDsF-gkOOXbfUV-y8g4Hw-i837OPp8X37ku3enl-397tsykuTMuNamyvZSS0q7arOdVBXumgNIFopK6WVdbpYFtHlVVHnIFSJRuUSUKGT5Ybd_u5OMXzNSKkZe7I4DOAxzNQoLYwsCrWIN3_i3I7omin2I8RT839T-Q0M4WYR</recordid><startdate>2004</startdate><enddate>2004</enddate><creator>Przybylski, Julio</creator><creator>Resnik, Miguel</creator><creator>Corsi, Miriam</creator><creator>Suez, Victor</creator><creator>Dervich, Roberto</creator><creator>Bevacqua, Raul</creator><creator>Lachitiello, Jorge</creator><creator>Elizari, Marcelo</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2004</creationdate><title>Cardiovascular response to mental and physical stress in hyper-reactive normotensive subjects. 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Beta blockade effect</atitle><jtitle>Medicina (Buenos Aires)</jtitle><addtitle>Medicina (B Aires)</addtitle><date>2004</date><risdate>2004</risdate><volume>64</volume><issue>5</issue><spage>390</spage><epage>394</epage><pages>390-394</pages><issn>0025-7680</issn><abstract>The aim of our study was to evaluate the cardiovascular reactivity in healthy normotensive subjects without medication, using mental and physical stress techniques: Stroop color word conflict test (SCWCT), anticipatory blood pressure response to exercise (ARE) and stress testing (ST). We analized the effects of a selective beta 1 betablocker: bisoprolol (B) on cardiovascular reactivity in our subjects (s). We studied 42 s, but only 30 (21 females and 9 males) were included who were hyperreactives. The mean age was 42.5 years. The higher values of systolic (SBP) and diastolic blood pressure (DBP) during the mental stress (MS) were taken as a measure of reactivity considering hyperreactive response an increase of 30 mm Hg or more and/or 15 mm Hg or more respectively. A prospective, randomized and double blind study on the effects of an oral daily doses of B (5 mg) vs placebo (P) was performed. Statistical analysis was realized with the Fisher exact test. In the results, we could observed a lower sensitivity of ARE and ST vs SCWCT. The 15 s who recieved P followed hyperreactives but 6 of 15 s treated with B were non reactives (p<0.017). B showed a beneficial effect on the hyperreactivity in a significant number of s in relation with P and it could be useful for the prevention of a future hypertension.</abstract><cop>Argentina</cop><pmid>15560538</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Medicina (Buenos Aires), 2004, Vol.64 (5), p.390-394 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adrenergic beta-Antagonists - pharmacology Adult Bisoprolol - pharmacology Blood Pressure - drug effects Blood Pressure - physiology Cardiovascular System - drug effects Double-Blind Method Exercise Test Female Heart Rate - drug effects Heart Rate - physiology Humans Male Middle Aged Neuropsychological Tests Prospective Studies Stress, Psychological - physiopathology |
| title | Cardiovascular response to mental and physical stress in hyper-reactive normotensive subjects. Beta blockade effect |
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