Emodin Induces Apoptosis of Human Tongue Squamous Cancer SCC-4 Cells through Reactive Oxygen Species and Mitochondria-dependent Pathways

Emodin was isolated from Rheum palmatum L. and exhibits an anticancer effect on human cancer cell lines, however, the molecular mechanisms of emodin-mediated apoptosis in human tongue cancer cells have not been fully investigated. In this study, treatment of human tongue cancer SCC-4 cells with vari...

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Veröffentlicht in:	Anticancer research 2009-01, Vol.29 (1), p.327-335
Hauptverfasser:	LIN, Shuw-Yuan, LAI, Wan-Wen, CHUNG, Jing-Gung, HO, Chin-Chin, YU, Fu-Shun, CHEN, Guang-Wei, YANG, Jai-Sing, LIU, Kuo-Ching, LIN, Meng-Liang, WU, Ping-Ping, FAN, Ming-Jen
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Apoptosis - physiology Biological and medical sciences Calcium - metabolism Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Caspase 3 - metabolism Caspase 9 - metabolism CDC2 Protein Kinase Cell Division - drug effects Checkpoint Kinase 2 Cyclin B - antagonists & inhibitors Cyclin B1 Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis Cyclin-Dependent Kinases DNA Damage Emodin - pharmacology G2 Phase - drug effects Humans Medical sciences Membrane Potential, Mitochondrial - drug effects Mitochondria - drug effects Mitochondria - physiology Otorhinolaryngology. Stomatology Protein-Serine-Threonine Kinases - biosynthesis Reactive Oxygen Species - metabolism Tongue Neoplasms - drug therapy Tongue Neoplasms - metabolism Tongue Neoplasms - pathology Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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