Ursodeoxycholic acid inhibits endothelin-1 production in human vascular endothelial cells
Endothelin-1 is known to be implicated in the pathogenesis of hepatobiliary diseases such as cirrhosis, especially in portal hypertension. This study aimed to investigate the effects of ursodeoxycholic acid on endothelin-1 production in human endothelial cells. The effects of ursodeoxycholic acid an...
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| Veröffentlicht in: | European journal of pharmacology 2004-11, Vol.505 (1), p.67-74 |
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| creator | Ma, Ji Iida, Haruko Jo, Taisuke Takano, Haruhito Oonuma, Hitoshi Morita, Toshihiro Toyo-oka, Teruhiko Omata, Masao Nagai, Ryozo Okuda, Yukichi Yamada, Nobuhiro Nakajima, Toshiaki |
| description | Endothelin-1 is known to be implicated in the pathogenesis of hepatobiliary diseases such as cirrhosis, especially in portal hypertension. This study aimed to investigate the effects of ursodeoxycholic acid on endothelin-1 production in human endothelial cells. The effects of ursodeoxycholic acid and its conjugates (tauroursodeoxycholic and glycoursodeoxycholic acids) on endothelin-1 production as well as nitric oxide (NO) in human umbilical vein endothelial cells (HUVECs) were examined. The production of endothelin-1 and nitric oxide in culture medium was measured using enzyme-linked immunosorbent assay (ELISA) and the Griess method, respectively. Endothelin-1 and endothelial nitric oxide synthase (eNOS) mRNA expression were investigated by real-time quantitative reverse transcriptase/polymerase chain reaction (RT-PCR). Ursodeoxycholic acid (30–1000 μM) inhibited endothelin-1 production in a concentration-dependent manner, and ursodeoxycholic acid at concentrations higher than 300 μM increased nitric oxide production in culture medium. The conjugates of ursodeoxycholic acid also increased nitric oxide production and decreased endothelin-1 production, which was less effective than ursodeoxycholic acid.
N-nitro-
l-arginine-mythel-ester (
l-NAME), a nitric oxide synthase (NOS) inhibitor, suppressed the ursodeoxycholic acid-induced nitric oxide production, but it did not antagonize the inhibitory effects of ursodeoxycholic acid on endothelin-1 production. Ursodeoxycholic acid also induced a concentration-dependent decrease in endothelin-1 mRNA expression without significant changes in eNOS mRNA expression. These results provide novel evidence that ursodeoxycholic acid inhibits endothelin-1 production in human endothelial cells, but nitric oxide is not responsible for the inhibitory effect of ursodeoxycholic acid on endothelin-1. Thus, ursodeoxycholic acid therapy may prevent the development of several pathogenesis such as portal hypertension observed in patients with cirrhosis due to the improvement of endothelial function. |
| doi_str_mv | 10.1016/j.ejphar.2004.10.042 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67094722</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0014299904012270</els_id><sourcerecordid>67094722</sourcerecordid><originalsourceid>FETCH-LOGICAL-c388t-7f9a14a3e610fc35117545e6915a7d1cafa8d89fa841e0f12a6669aaf1acc5353</originalsourceid><addsrcrecordid>eNp9kMFqGzEQhkVoiN20b1DKXprbuhrtSru6FEpomoChl-SQk5hIs6zMeuVKu6Z--8jY4FsvMzB8__DzMfYF-Ao4qO-bFW12PcaV4LzOpxWvxRVbQtvokjcgPrAl51CXQmu9YB9T2nDOpRbyhi1ASqmgapfs9SWm4Cj8O9g-DN4WaL0r_Nj7Nz-lgkYXpp4GP5ZQ7GJws518GDNQ9PMWx2KPyc4DxguJQ2FpGNIndt3hkOjzed-yl4dfz_eP5frP76f7n-vSVm07lU2nEWqsSAHvbCUBGllLUhokNg4sdti6VudZA_EOBCqlNGIHaK2sZHXL7k5_c72_M6XJbH06NsCRwpyMariuGyEyWJ9AG0NKkTqzi36L8WCAm6NSszEnpeao9HjNSnPs6_n__LYldwmdHWbg2xnILnDoIo7WpwunhIZKNZn7ceIo29h7iiZZT6Ml5yPZybjg_9_kHaXFl7Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67094722</pqid></control><display><type>article</type><title>Ursodeoxycholic acid inhibits endothelin-1 production in human vascular endothelial cells</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Ma, Ji ; Iida, Haruko ; Jo, Taisuke ; Takano, Haruhito ; Oonuma, Hitoshi ; Morita, Toshihiro ; Toyo-oka, Teruhiko ; Omata, Masao ; Nagai, Ryozo ; Okuda, Yukichi ; Yamada, Nobuhiro ; Nakajima, Toshiaki</creator><creatorcontrib>Ma, Ji ; Iida, Haruko ; Jo, Taisuke ; Takano, Haruhito ; Oonuma, Hitoshi ; Morita, Toshihiro ; Toyo-oka, Teruhiko ; Omata, Masao ; Nagai, Ryozo ; Okuda, Yukichi ; Yamada, Nobuhiro ; Nakajima, Toshiaki</creatorcontrib><description>Endothelin-1 is known to be implicated in the pathogenesis of hepatobiliary diseases such as cirrhosis, especially in portal hypertension. This study aimed to investigate the effects of ursodeoxycholic acid on endothelin-1 production in human endothelial cells. The effects of ursodeoxycholic acid and its conjugates (tauroursodeoxycholic and glycoursodeoxycholic acids) on endothelin-1 production as well as nitric oxide (NO) in human umbilical vein endothelial cells (HUVECs) were examined. The production of endothelin-1 and nitric oxide in culture medium was measured using enzyme-linked immunosorbent assay (ELISA) and the Griess method, respectively. Endothelin-1 and endothelial nitric oxide synthase (eNOS) mRNA expression were investigated by real-time quantitative reverse transcriptase/polymerase chain reaction (RT-PCR). Ursodeoxycholic acid (30–1000 μM) inhibited endothelin-1 production in a concentration-dependent manner, and ursodeoxycholic acid at concentrations higher than 300 μM increased nitric oxide production in culture medium. The conjugates of ursodeoxycholic acid also increased nitric oxide production and decreased endothelin-1 production, which was less effective than ursodeoxycholic acid.
N-nitro-
l-arginine-mythel-ester (
l-NAME), a nitric oxide synthase (NOS) inhibitor, suppressed the ursodeoxycholic acid-induced nitric oxide production, but it did not antagonize the inhibitory effects of ursodeoxycholic acid on endothelin-1 production. Ursodeoxycholic acid also induced a concentration-dependent decrease in endothelin-1 mRNA expression without significant changes in eNOS mRNA expression. These results provide novel evidence that ursodeoxycholic acid inhibits endothelin-1 production in human endothelial cells, but nitric oxide is not responsible for the inhibitory effect of ursodeoxycholic acid on endothelin-1. Thus, ursodeoxycholic acid therapy may prevent the development of several pathogenesis such as portal hypertension observed in patients with cirrhosis due to the improvement of endothelial function.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/j.ejphar.2004.10.042</identifier><identifier>PMID: 15556138</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Biological and medical sciences ; Cell Line ; Dose-Response Relationship, Drug ; Endothelial Cells - drug effects ; Endothelial Cells - metabolism ; Endothelin-1 ; Endothelin-1 - biosynthesis ; Endothelin-1 - genetics ; Enzyme Inhibitors - pharmacology ; Enzyme-Linked Immunosorbent Assay ; Gene Expression - drug effects ; Human endothelial cell ; Humans ; Medical sciences ; NG-Nitroarginine Methyl Ester - pharmacology ; Nitric oxide ; Nitric Oxide - biosynthesis ; Nitric Oxide Synthase - antagonists & inhibitors ; Nitric Oxide Synthase - genetics ; Nitric Oxide Synthase Type III ; Pharmacology. Drug treatments ; Real-time RT-PCR ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Ursodeoxycholic acid ; Ursodeoxycholic Acid - pharmacology</subject><ispartof>European journal of pharmacology, 2004-11, Vol.505 (1), p.67-74</ispartof><rights>2004 Elsevier B.V.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-7f9a14a3e610fc35117545e6915a7d1cafa8d89fa841e0f12a6669aaf1acc5353</citedby><cites>FETCH-LOGICAL-c388t-7f9a14a3e610fc35117545e6915a7d1cafa8d89fa841e0f12a6669aaf1acc5353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014299904012270$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16291367$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15556138$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Ji</creatorcontrib><creatorcontrib>Iida, Haruko</creatorcontrib><creatorcontrib>Jo, Taisuke</creatorcontrib><creatorcontrib>Takano, Haruhito</creatorcontrib><creatorcontrib>Oonuma, Hitoshi</creatorcontrib><creatorcontrib>Morita, Toshihiro</creatorcontrib><creatorcontrib>Toyo-oka, Teruhiko</creatorcontrib><creatorcontrib>Omata, Masao</creatorcontrib><creatorcontrib>Nagai, Ryozo</creatorcontrib><creatorcontrib>Okuda, Yukichi</creatorcontrib><creatorcontrib>Yamada, Nobuhiro</creatorcontrib><creatorcontrib>Nakajima, Toshiaki</creatorcontrib><title>Ursodeoxycholic acid inhibits endothelin-1 production in human vascular endothelial cells</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Endothelin-1 is known to be implicated in the pathogenesis of hepatobiliary diseases such as cirrhosis, especially in portal hypertension. This study aimed to investigate the effects of ursodeoxycholic acid on endothelin-1 production in human endothelial cells. The effects of ursodeoxycholic acid and its conjugates (tauroursodeoxycholic and glycoursodeoxycholic acids) on endothelin-1 production as well as nitric oxide (NO) in human umbilical vein endothelial cells (HUVECs) were examined. The production of endothelin-1 and nitric oxide in culture medium was measured using enzyme-linked immunosorbent assay (ELISA) and the Griess method, respectively. Endothelin-1 and endothelial nitric oxide synthase (eNOS) mRNA expression were investigated by real-time quantitative reverse transcriptase/polymerase chain reaction (RT-PCR). Ursodeoxycholic acid (30–1000 μM) inhibited endothelin-1 production in a concentration-dependent manner, and ursodeoxycholic acid at concentrations higher than 300 μM increased nitric oxide production in culture medium. The conjugates of ursodeoxycholic acid also increased nitric oxide production and decreased endothelin-1 production, which was less effective than ursodeoxycholic acid.
N-nitro-
l-arginine-mythel-ester (
l-NAME), a nitric oxide synthase (NOS) inhibitor, suppressed the ursodeoxycholic acid-induced nitric oxide production, but it did not antagonize the inhibitory effects of ursodeoxycholic acid on endothelin-1 production. Ursodeoxycholic acid also induced a concentration-dependent decrease in endothelin-1 mRNA expression without significant changes in eNOS mRNA expression. These results provide novel evidence that ursodeoxycholic acid inhibits endothelin-1 production in human endothelial cells, but nitric oxide is not responsible for the inhibitory effect of ursodeoxycholic acid on endothelin-1. Thus, ursodeoxycholic acid therapy may prevent the development of several pathogenesis such as portal hypertension observed in patients with cirrhosis due to the improvement of endothelial function.</description><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Dose-Response Relationship, Drug</subject><subject>Endothelial Cells - drug effects</subject><subject>Endothelial Cells - metabolism</subject><subject>Endothelin-1</subject><subject>Endothelin-1 - biosynthesis</subject><subject>Endothelin-1 - genetics</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Gene Expression - drug effects</subject><subject>Human endothelial cell</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>NG-Nitroarginine Methyl Ester - pharmacology</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - biosynthesis</subject><subject>Nitric Oxide Synthase - antagonists & inhibitors</subject><subject>Nitric Oxide Synthase - genetics</subject><subject>Nitric Oxide Synthase Type III</subject><subject>Pharmacology. Drug treatments</subject><subject>Real-time RT-PCR</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Ursodeoxycholic acid</subject><subject>Ursodeoxycholic Acid - pharmacology</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFqGzEQhkVoiN20b1DKXprbuhrtSru6FEpomoChl-SQk5hIs6zMeuVKu6Z--8jY4FsvMzB8__DzMfYF-Ao4qO-bFW12PcaV4LzOpxWvxRVbQtvokjcgPrAl51CXQmu9YB9T2nDOpRbyhi1ASqmgapfs9SWm4Cj8O9g-DN4WaL0r_Nj7Nz-lgkYXpp4GP5ZQ7GJws518GDNQ9PMWx2KPyc4DxguJQ2FpGNIndt3hkOjzed-yl4dfz_eP5frP76f7n-vSVm07lU2nEWqsSAHvbCUBGllLUhokNg4sdti6VudZA_EOBCqlNGIHaK2sZHXL7k5_c72_M6XJbH06NsCRwpyMariuGyEyWJ9AG0NKkTqzi36L8WCAm6NSszEnpeao9HjNSnPs6_n__LYldwmdHWbg2xnILnDoIo7WpwunhIZKNZn7ceIo29h7iiZZT6Ml5yPZybjg_9_kHaXFl7Q</recordid><startdate>20041128</startdate><enddate>20041128</enddate><creator>Ma, Ji</creator><creator>Iida, Haruko</creator><creator>Jo, Taisuke</creator><creator>Takano, Haruhito</creator><creator>Oonuma, Hitoshi</creator><creator>Morita, Toshihiro</creator><creator>Toyo-oka, Teruhiko</creator><creator>Omata, Masao</creator><creator>Nagai, Ryozo</creator><creator>Okuda, Yukichi</creator><creator>Yamada, Nobuhiro</creator><creator>Nakajima, Toshiaki</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041128</creationdate><title>Ursodeoxycholic acid inhibits endothelin-1 production in human vascular endothelial cells</title><author>Ma, Ji ; Iida, Haruko ; Jo, Taisuke ; Takano, Haruhito ; Oonuma, Hitoshi ; Morita, Toshihiro ; Toyo-oka, Teruhiko ; Omata, Masao ; Nagai, Ryozo ; Okuda, Yukichi ; Yamada, Nobuhiro ; Nakajima, Toshiaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-7f9a14a3e610fc35117545e6915a7d1cafa8d89fa841e0f12a6669aaf1acc5353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Dose-Response Relationship, Drug</topic><topic>Endothelial Cells - drug effects</topic><topic>Endothelial Cells - metabolism</topic><topic>Endothelin-1</topic><topic>Endothelin-1 - biosynthesis</topic><topic>Endothelin-1 - genetics</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Gene Expression - drug effects</topic><topic>Human endothelial cell</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>NG-Nitroarginine Methyl Ester - pharmacology</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - biosynthesis</topic><topic>Nitric Oxide Synthase - antagonists & inhibitors</topic><topic>Nitric Oxide Synthase - genetics</topic><topic>Nitric Oxide Synthase Type III</topic><topic>Pharmacology. Drug treatments</topic><topic>Real-time RT-PCR</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Ursodeoxycholic acid</topic><topic>Ursodeoxycholic Acid - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Ji</creatorcontrib><creatorcontrib>Iida, Haruko</creatorcontrib><creatorcontrib>Jo, Taisuke</creatorcontrib><creatorcontrib>Takano, Haruhito</creatorcontrib><creatorcontrib>Oonuma, Hitoshi</creatorcontrib><creatorcontrib>Morita, Toshihiro</creatorcontrib><creatorcontrib>Toyo-oka, Teruhiko</creatorcontrib><creatorcontrib>Omata, Masao</creatorcontrib><creatorcontrib>Nagai, Ryozo</creatorcontrib><creatorcontrib>Okuda, Yukichi</creatorcontrib><creatorcontrib>Yamada, Nobuhiro</creatorcontrib><creatorcontrib>Nakajima, Toshiaki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Ji</au><au>Iida, Haruko</au><au>Jo, Taisuke</au><au>Takano, Haruhito</au><au>Oonuma, Hitoshi</au><au>Morita, Toshihiro</au><au>Toyo-oka, Teruhiko</au><au>Omata, Masao</au><au>Nagai, Ryozo</au><au>Okuda, Yukichi</au><au>Yamada, Nobuhiro</au><au>Nakajima, Toshiaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ursodeoxycholic acid inhibits endothelin-1 production in human vascular endothelial cells</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2004-11-28</date><risdate>2004</risdate><volume>505</volume><issue>1</issue><spage>67</spage><epage>74</epage><pages>67-74</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>Endothelin-1 is known to be implicated in the pathogenesis of hepatobiliary diseases such as cirrhosis, especially in portal hypertension. This study aimed to investigate the effects of ursodeoxycholic acid on endothelin-1 production in human endothelial cells. The effects of ursodeoxycholic acid and its conjugates (tauroursodeoxycholic and glycoursodeoxycholic acids) on endothelin-1 production as well as nitric oxide (NO) in human umbilical vein endothelial cells (HUVECs) were examined. The production of endothelin-1 and nitric oxide in culture medium was measured using enzyme-linked immunosorbent assay (ELISA) and the Griess method, respectively. Endothelin-1 and endothelial nitric oxide synthase (eNOS) mRNA expression were investigated by real-time quantitative reverse transcriptase/polymerase chain reaction (RT-PCR). Ursodeoxycholic acid (30–1000 μM) inhibited endothelin-1 production in a concentration-dependent manner, and ursodeoxycholic acid at concentrations higher than 300 μM increased nitric oxide production in culture medium. The conjugates of ursodeoxycholic acid also increased nitric oxide production and decreased endothelin-1 production, which was less effective than ursodeoxycholic acid.
N-nitro-
l-arginine-mythel-ester (
l-NAME), a nitric oxide synthase (NOS) inhibitor, suppressed the ursodeoxycholic acid-induced nitric oxide production, but it did not antagonize the inhibitory effects of ursodeoxycholic acid on endothelin-1 production. Ursodeoxycholic acid also induced a concentration-dependent decrease in endothelin-1 mRNA expression without significant changes in eNOS mRNA expression. These results provide novel evidence that ursodeoxycholic acid inhibits endothelin-1 production in human endothelial cells, but nitric oxide is not responsible for the inhibitory effect of ursodeoxycholic acid on endothelin-1. Thus, ursodeoxycholic acid therapy may prevent the development of several pathogenesis such as portal hypertension observed in patients with cirrhosis due to the improvement of endothelial function.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>15556138</pmid><doi>10.1016/j.ejphar.2004.10.042</doi><tpages>8</tpages></addata></record> |
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| subjects | Biological and medical sciences Cell Line Dose-Response Relationship, Drug Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelin-1 Endothelin-1 - biosynthesis Endothelin-1 - genetics Enzyme Inhibitors - pharmacology Enzyme-Linked Immunosorbent Assay Gene Expression - drug effects Human endothelial cell Humans Medical sciences NG-Nitroarginine Methyl Ester - pharmacology Nitric oxide Nitric Oxide - biosynthesis Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type III Pharmacology. Drug treatments Real-time RT-PCR Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Ursodeoxycholic acid Ursodeoxycholic Acid - pharmacology |
| title | Ursodeoxycholic acid inhibits endothelin-1 production in human vascular endothelial cells |
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