Preventive Effect of SA13353 [1-[2-(1-Adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea], a Novel Transient Receptor Potential Vanilloid 1 Agonist, on Ischemia/Reperfusion-Induced Renal Injury in Rats

Tumor necrosis factor (TNF)-Î± plays a crucial role in the pathogenesis of ischemia/reperfusion-induced renal injury. We demonstrated recently that the preischemic treatment with resiniferatoxin, a transient receptor potential vanilloid 1 (TRPV1) agonist, attenuates renal TNF-Î± mRNA expression and...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2009-04, Vol.329 (1), p.202-209
Hauptverfasser:	Ueda, Kyoko, Tsuji, Fumio, Hirata, Tomoko, Ueda, Kenji, Murai, Masaaki, Aono, Hiroyuki, Takaoka, Masanori, Matsumura, Yasuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Interleukin-10 - physiology Kidney Diseases - drug therapy Kidney Diseases - pathology Kidney Function Tests Male Neutrophil Infiltration - drug effects Pyridines - pharmacokinetics Pyridines - therapeutic use Rats Rats, Sprague-Dawley Reactive Oxygen Species Reperfusion Injury - drug therapy Reperfusion Injury - pathology Reverse Transcriptase Polymerase Chain Reaction RNA - biosynthesis RNA - genetics TRPV Cation Channels - agonists Tumor Necrosis Factor-alpha - physiology Urea - analogs & derivatives Urea - pharmacokinetics Urea - therapeutic use
Online-Zugang:	Volltext
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