Effects of SEA0400, a novel inhibitor of the Na+/Ca2+ exchanger, on myocardial stunning in anesthetized dogs

Activation of the Na+/Ca2+ exchanger may contribute to Ca2+ overload during reperfusion after transient ischemia. We examined the effects of 2-[4-[(2,5-difluorophenyl) methoxy]phenoxy]-5-ethoxyaniline (SEA0400), a selective inhibitor of Na+/Ca2+ exchange, on a canine model of ischemia/reperfusion in...

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Veröffentlicht in:	European journal of pharmacology 2004-11, Vol.505 (1-3), p.163-168
Hauptverfasser:	TAKAHASHI, Teisuke, TAKAHASHI, Kenzo, ONISHI, Michihito, SUZUKI, Taizo, TANAKA, Yu, OTA, Tomomi, YOSHIDA, Shigeru, NAKAIKE, Shiro, MATSUDA, Toshio, BABA, Akemichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Aniline Compounds - pharmacology Animals Biological and medical sciences Blood Pressure - drug effects Dogs Female Heart - drug effects Heart - physiopathology Heart Rate - drug effects Male Medical sciences Myocardial Reperfusion Injury - complications Myocardial Stunning - etiology Myocardial Stunning - physiopathology Myocardial Stunning - prevention & control Pharmacology. Drug treatments Phenyl Ethers - pharmacology Random Allocation Sodium-Calcium Exchanger - antagonists & inhibitors Time Factors
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