The tumor protein D52 family: many pieces, many puzzles
Tumor protein D52-like proteins are small coiled-coil motif bearing proteins which are conserved from lower organisms to human. The founding member of the family, human D52, has principally attracted research interest due to its frequent overexpression in cancer, often in association with D52 gene a...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2004-12, Vol.325 (4), p.1115-1121 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Boutros, Rose Fanayan, Susan Shehata, Mona Byrne, Jennifer A. |
| description | Tumor protein D52-like proteins are small coiled-coil motif bearing proteins which are conserved from lower organisms to human. The founding member of the family, human D52, has principally attracted research interest due to its frequent overexpression in cancer, often in association with
D52 gene amplification. This review summarises published literature concerning this protein family since their discovery, which is highlighting an increasing diversity of functions for D52-like proteins. This in turn highlights a need for more comparative functional analyses, to determine which functions are conserved and which may be isoform-specific. This knowledge will be crucial for any future manipulation of D52 function in human disease, including cancer. |
| doi_str_mv | 10.1016/j.bbrc.2004.10.112 |
| format | Article |
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D52 gene amplification. This review summarises published literature concerning this protein family since their discovery, which is highlighting an increasing diversity of functions for D52-like proteins. This in turn highlights a need for more comparative functional analyses, to determine which functions are conserved and which may be isoform-specific. This knowledge will be crucial for any future manipulation of D52 function in human disease, including cancer.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Biomarkers, Tumor - chemistry</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Breast carcinoma</subject><subject>Chromosome 8q21</subject><subject>CRHSP28</subject><subject>CSPP28</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Molecular Sequence Data</subject><subject>Neoplasm Proteins - chemistry</subject><subject>Neoplasm Proteins - classification</subject><subject>Neoplasm Proteins - metabolism</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - metabolism</subject><subject>Prostate carcinoma</subject><subject>Protein Conformation</subject><subject>R10</subject><subject>Structure-Activity Relationship</subject><subject>Tumor protein D52</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMo7rr6BzxIT55szSTdtBEvsn7CgpcVvIUmnWKWfqxJK-z-elu34E3nksnwzMvwEHIONAIK4nodae1MxCiNo2EG7IBMgUoaMqDxIZlSSkXIJLxPyIn3a0oBYiGPyQTmQ8V8SpLVBwZtVzUu2LimRVsH93MWFFlly-1NUGX1NthYNOivxk-325XoT8lRkZUez8Z3Rt4eH1aL53D5-vSyuFuGJo5lG6ZM9w3lkgtMjQCUaHjCU2CYCSiEYDrh80QUJi0EF3nOudGZhizVSRFrymfkcp_bX_fZoW9VZb3BssxqbDqvREIlcCn-BSFJe2cx70G2B41rvHdYqI2zVea2CqgavKq1GryqwevPDFi_dDGmd7rC_HdlFNkDt3sAexlfFp3yxmJtMLcOTavyxv6V_w2tfIc8</recordid><startdate>20041224</startdate><enddate>20041224</enddate><creator>Boutros, Rose</creator><creator>Fanayan, Susan</creator><creator>Shehata, Mona</creator><creator>Byrne, Jennifer A.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20041224</creationdate><title>The tumor protein D52 family: many pieces, many puzzles</title><author>Boutros, Rose ; Fanayan, Susan ; Shehata, Mona ; Byrne, Jennifer A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-82bc4403936e8c61e9ec373812ea61f662b73576fc8f636dd33cbab1a8b7f4b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Biomarkers, Tumor - chemistry</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Breast carcinoma</topic><topic>Chromosome 8q21</topic><topic>CRHSP28</topic><topic>CSPP28</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Molecular Sequence Data</topic><topic>Neoplasm Proteins - chemistry</topic><topic>Neoplasm Proteins - classification</topic><topic>Neoplasm Proteins - metabolism</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - metabolism</topic><topic>Prostate carcinoma</topic><topic>Protein Conformation</topic><topic>R10</topic><topic>Structure-Activity Relationship</topic><topic>Tumor protein D52</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boutros, Rose</creatorcontrib><creatorcontrib>Fanayan, Susan</creatorcontrib><creatorcontrib>Shehata, Mona</creatorcontrib><creatorcontrib>Byrne, Jennifer A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boutros, Rose</au><au>Fanayan, Susan</au><au>Shehata, Mona</au><au>Byrne, Jennifer A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The tumor protein D52 family: many pieces, many puzzles</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2004-12-24</date><risdate>2004</risdate><volume>325</volume><issue>4</issue><spage>1115</spage><epage>1121</epage><pages>1115-1121</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Tumor protein D52-like proteins are small coiled-coil motif bearing proteins which are conserved from lower organisms to human. 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D52 gene amplification. This review summarises published literature concerning this protein family since their discovery, which is highlighting an increasing diversity of functions for D52-like proteins. This in turn highlights a need for more comparative functional analyses, to determine which functions are conserved and which may be isoform-specific. This knowledge will be crucial for any future manipulation of D52 function in human disease, including cancer.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15555543</pmid><doi>10.1016/j.bbrc.2004.10.112</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Amino Acid Sequence Animals Biomarkers, Tumor - chemistry Biomarkers, Tumor - metabolism Breast carcinoma Chromosome 8q21 CRHSP28 CSPP28 Gene Expression Regulation, Neoplastic Humans Molecular Sequence Data Neoplasm Proteins - chemistry Neoplasm Proteins - classification Neoplasm Proteins - metabolism Neoplasms - genetics Neoplasms - metabolism Prostate carcinoma Protein Conformation R10 Structure-Activity Relationship Tumor protein D52 |
| title | The tumor protein D52 family: many pieces, many puzzles |
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