Management and investigation of neonatal thromboembolic events: Genetic and acquired risk factors
A bstract Newborns comprise the largest group of children developing thromoboembolic events (TES ), due to the peculiarities of their developmental hemostatic system. Moreover, in the sick newborn, especially preterm, numerous acquired perinatal and iatrogenic conditions might result in a disturbanc...
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| Veröffentlicht in: | Thrombosis research 2009-04, Vol.123 (6), p.805-809 |
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| creator | Saracco, P Parodi, E Fabris, C Cecinati, V Molinari, A.C Giordano, P |
| description | A bstract Newborns comprise the largest group of children developing thromoboembolic events (TES ), due to the peculiarities of their developmental hemostatic system. Moreover, in the sick newborn, especially preterm, numerous acquired perinatal and iatrogenic conditions might result in a disturbance between coagulation and fibrinolysis, leading to thrombus formation. Nevertheless, the contribution of acquired prothrombotic disorders in the pathogenesis of thromboembolic disease in newborns remains poorly defined. Few data are currently available regarding the influence of maternal or fetal genes on thrombotic risk in the fetus and neonate. Ongoing National and International registries are partially answering these questions. The purpose of this review is to evaluate the current knowledge about the role of inherited, acquired perinatal and maternal prothrombotic risk factors in neonatal cerebral nervous system (CNS) thrombotic events and non-CNS thrombotic events. |
| doi_str_mv | 10.1016/j.thromres.2008.12.002 |
| format | Article |
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Moreover, in the sick newborn, especially preterm, numerous acquired perinatal and iatrogenic conditions might result in a disturbance between coagulation and fibrinolysis, leading to thrombus formation. Nevertheless, the contribution of acquired prothrombotic disorders in the pathogenesis of thromboembolic disease in newborns remains poorly defined. Few data are currently available regarding the influence of maternal or fetal genes on thrombotic risk in the fetus and neonate. Ongoing National and International registries are partially answering these questions. 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Miscellaneous ; Female ; Heart ; Hematology, Oncology and Palliative Medicine ; Hemostasis ; Humans ; Infant, Newborn ; Maternal ; Maternal-Fetal Exchange ; Medical sciences ; Newborn ; Pregnancy ; Risk Factors ; Stroke ; Thromboembolism - blood ; Thromboembolism - etiology ; Thromboembolism - genetics ; Thrombophilia ; Thrombophilia - genetics ; Thrombosis ; Thrombosis - etiology</subject><ispartof>Thrombosis research, 2009-04, Vol.123 (6), p.805-809</ispartof><rights>Elsevier Ltd</rights><rights>2008 Elsevier Ltd</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-19ec2190e4a39862090bb0e89734fb7d8e09ecdbd3d2786e8c405e0524b190173</citedby><cites>FETCH-LOGICAL-c451t-19ec2190e4a39862090bb0e89734fb7d8e09ecdbd3d2786e8c405e0524b190173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.thromres.2008.12.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,46004</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21398180$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19167028$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saracco, P</creatorcontrib><creatorcontrib>Parodi, E</creatorcontrib><creatorcontrib>Fabris, C</creatorcontrib><creatorcontrib>Cecinati, V</creatorcontrib><creatorcontrib>Molinari, A.C</creatorcontrib><creatorcontrib>Giordano, P</creatorcontrib><title>Management and investigation of neonatal thromboembolic events: Genetic and acquired risk factors</title><title>Thrombosis research</title><addtitle>Thromb Res</addtitle><description>A bstract Newborns comprise the largest group of children developing thromoboembolic events (TES ), due to the peculiarities of their developmental hemostatic system. Moreover, in the sick newborn, especially preterm, numerous acquired perinatal and iatrogenic conditions might result in a disturbance between coagulation and fibrinolysis, leading to thrombus formation. Nevertheless, the contribution of acquired prothrombotic disorders in the pathogenesis of thromboembolic disease in newborns remains poorly defined. Few data are currently available regarding the influence of maternal or fetal genes on thrombotic risk in the fetus and neonate. Ongoing National and International registries are partially answering these questions. The purpose of this review is to evaluate the current knowledge about the role of inherited, acquired perinatal and maternal prothrombotic risk factors in neonatal cerebral nervous system (CNS) thrombotic events and non-CNS thrombotic events.</description><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Central Nervous System Diseases - etiology</subject><subject>Coronary heart disease</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Female</subject><subject>Heart</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Hemostasis</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Maternal</subject><subject>Maternal-Fetal Exchange</subject><subject>Medical sciences</subject><subject>Newborn</subject><subject>Pregnancy</subject><subject>Risk Factors</subject><subject>Stroke</subject><subject>Thromboembolism - blood</subject><subject>Thromboembolism - etiology</subject><subject>Thromboembolism - genetics</subject><subject>Thrombophilia</subject><subject>Thrombophilia - genetics</subject><subject>Thrombosis</subject><subject>Thrombosis - etiology</subject><issn>0049-3848</issn><issn>1879-2472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhi1ERbeFv1DlAreEGefL5oCoKihIrXoonC3HmRRvE7u1k5X673G6C0hcOFiWpeed8Twaxs4QCgRs3m-L-WfwU6BYcABRIC8A-Au2QdHKnFctf8k2AJXMS1GJY3YS4xYAW5T1K3aMEpsWuNgwfa2dvqOJ3Jxp12fW7SjO9k7P1rvMD5kj7_Ssx-y5X-cpndGajHYpEj9kl-RoTu81rM3jYgP1WbDxPhu0mX2Ir9nRoMdIbw73Kfvx5fP3i6_51c3lt4vzq9xUNc45SjIcJVClSykaDhK6DkjItqyGru0FQSL6ri973oqGhKmgJqh51aUUtuUpe7ev-xD845KGUJONhsZRpxGWqNLAEkvkCWz2oAk-xkCDegh20uFJIahVrtqq33LVKlchV0luCp4dOizdRP3f2MFmAt4eAB2NHoegnbHxD8cxTYYCEvdpz1HysbMUVDSWnKE-2TOz6r39_18-_lPCjNbZ1PWenihu_RJcsq1QxRRQt-sqrJsAAqCu26r8BX8BsW0</recordid><startdate>20090401</startdate><enddate>20090401</enddate><creator>Saracco, P</creator><creator>Parodi, E</creator><creator>Fabris, C</creator><creator>Cecinati, V</creator><creator>Molinari, A.C</creator><creator>Giordano, P</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090401</creationdate><title>Management and investigation of neonatal thromboembolic events: Genetic and acquired risk factors</title><author>Saracco, P ; Parodi, E ; Fabris, C ; Cecinati, V ; Molinari, A.C ; Giordano, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-19ec2190e4a39862090bb0e89734fb7d8e09ecdbd3d2786e8c405e0524b190173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Central Nervous System Diseases - etiology</topic><topic>Coronary heart disease</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Female</topic><topic>Heart</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Hemostasis</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Maternal</topic><topic>Maternal-Fetal Exchange</topic><topic>Medical sciences</topic><topic>Newborn</topic><topic>Pregnancy</topic><topic>Risk Factors</topic><topic>Stroke</topic><topic>Thromboembolism - blood</topic><topic>Thromboembolism - etiology</topic><topic>Thromboembolism - genetics</topic><topic>Thrombophilia</topic><topic>Thrombophilia - genetics</topic><topic>Thrombosis</topic><topic>Thrombosis - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saracco, P</creatorcontrib><creatorcontrib>Parodi, E</creatorcontrib><creatorcontrib>Fabris, C</creatorcontrib><creatorcontrib>Cecinati, V</creatorcontrib><creatorcontrib>Molinari, A.C</creatorcontrib><creatorcontrib>Giordano, P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saracco, P</au><au>Parodi, E</au><au>Fabris, C</au><au>Cecinati, V</au><au>Molinari, A.C</au><au>Giordano, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Management and investigation of neonatal thromboembolic events: Genetic and acquired risk factors</atitle><jtitle>Thrombosis research</jtitle><addtitle>Thromb Res</addtitle><date>2009-04-01</date><risdate>2009</risdate><volume>123</volume><issue>6</issue><spage>805</spage><epage>809</epage><pages>805-809</pages><issn>0049-3848</issn><eissn>1879-2472</eissn><coden>THBRAA</coden><abstract>A bstract Newborns comprise the largest group of children developing thromoboembolic events (TES ), due to the peculiarities of their developmental hemostatic system. Moreover, in the sick newborn, especially preterm, numerous acquired perinatal and iatrogenic conditions might result in a disturbance between coagulation and fibrinolysis, leading to thrombus formation. Nevertheless, the contribution of acquired prothrombotic disorders in the pathogenesis of thromboembolic disease in newborns remains poorly defined. Few data are currently available regarding the influence of maternal or fetal genes on thrombotic risk in the fetus and neonate. Ongoing National and International registries are partially answering these questions. The purpose of this review is to evaluate the current knowledge about the role of inherited, acquired perinatal and maternal prothrombotic risk factors in neonatal cerebral nervous system (CNS) thrombotic events and non-CNS thrombotic events.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>19167028</pmid><doi>10.1016/j.thromres.2008.12.002</doi><tpages>5</tpages></addata></record> |
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| subjects | Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Central Nervous System Diseases - etiology Coronary heart disease Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female Heart Hematology, Oncology and Palliative Medicine Hemostasis Humans Infant, Newborn Maternal Maternal-Fetal Exchange Medical sciences Newborn Pregnancy Risk Factors Stroke Thromboembolism - blood Thromboembolism - etiology Thromboembolism - genetics Thrombophilia Thrombophilia - genetics Thrombosis Thrombosis - etiology |
| title | Management and investigation of neonatal thromboembolic events: Genetic and acquired risk factors |
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