Overexpression of 5α-reductase type 1 increases sensitivity of prostate cancer cells to low concentrations of testosterone

INTRODUCTION Conversion of testosterone to dihydrotestosterone (DHT) by the enzymes 5α‐reductase types 1 (5αR1) and 2 (5αR2) is important for normal and pathological growth of the prostate. The predominant isoenzyme in normal prostate is 5αR2. However, prostate cancer (PCa) development is accompanie...

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Veröffentlicht in:	The Prostate 2009-05, Vol.69 (6), p.595-602
Hauptverfasser:	Thomas, Lynn N., Douglas, Robert C., Rittmaster, Roger S., Too, Catherine K.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics castration-recurrent prostate cancer Cell Line, Tumor dihydrotestosterone DNA Primers DNA, Complementary - genetics DNA, Complementary - isolation & purification DNA, Neoplasm - genetics DNA, Neoplasm - isolation & purification dutasteride finasteride Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Humans Isoenzymes - genetics Male Prostate-Specific Antigen - genetics Prostatic Neoplasms - enzymology Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Neoplasm - genetics Testosterone - pharmacology Transfection Up-Regulation
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