Antimicrobial activities of components of the glandular secretions of leaf cutting ants of the genus Atta
The secretions of the mandibular and metapleural glands of leaf cutting ants contain antimicrobial substances that protect the mutualistic fungal colony within the nest from attack by parasitic micro-organisms. The major constituents of these secretions (citral, 4-methyl-3-heptanol, 2-heptanone, 3-o...
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| Veröffentlicht in: | Antonie van Leeuwenhoek 2009-05, Vol.95 (4), p.295-303 |
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| creator | de Lima Mendonça, Adriana da Silva, Carlos Eduardo de Mesquita, Fernando Lucas Torres da Silva Campos, Rousseau Do Nascimento, Ruth R de Azevedo Ximenes, Eulália Camelo Pessoa Sant'Ana, Antônio Euzébio G |
| description | The secretions of the mandibular and metapleural glands of leaf cutting ants contain antimicrobial substances that protect the mutualistic fungal colony within the nest from attack by parasitic micro-organisms. The major constituents of these secretions (citral, 4-methyl-3-heptanol, 2-heptanone, 3-octanone, 4-methyl-2-heptanone, β-citronellol, geraniol, phenylacetic, indolacetic, hexanoic and octanoic acids were tested against resistant strains of the human pathogens, Escherichia coli, Staphylococcus aureus and Candida albicans. Assays were carried out using filter paper discs impregnated with either hexane or water solutions of the analytes in the concentration range 250-6,000 ng/μl. Although most of the tested compounds presented strong antibacterial and antifungal activities, citral, geraniol, 4-methyl-3-heptanol, hexanoic and octanoic acids were the most effective, particularly against C. albicans. The results suggest that these compounds may be of potential value as antibiotics in the treatment of human candidiasis. |
| doi_str_mv | 10.1007/s10482-009-9312-0 |
| format | Article |
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The major constituents of these secretions (citral, 4-methyl-3-heptanol, 2-heptanone, 3-octanone, 4-methyl-2-heptanone, β-citronellol, geraniol, phenylacetic, indolacetic, hexanoic and octanoic acids were tested against resistant strains of the human pathogens, Escherichia coli, Staphylococcus aureus and Candida albicans. Assays were carried out using filter paper discs impregnated with either hexane or water solutions of the analytes in the concentration range 250-6,000 ng/μl. Although most of the tested compounds presented strong antibacterial and antifungal activities, citral, geraniol, 4-methyl-3-heptanol, hexanoic and octanoic acids were the most effective, particularly against C. albicans. The results suggest that these compounds may be of potential value as antibiotics in the treatment of human candidiasis.</description><identifier>ISSN: 0003-6072</identifier><identifier>EISSN: 1572-9699</identifier><identifier>DOI: 10.1007/s10482-009-9312-0</identifier><identifier>PMID: 19214771</identifier><identifier>CODEN: ANLEDR</identifier><language>eng</language><publisher>Dordrecht: Dordrecht : Springer Netherlands</publisher><subject><![CDATA[Animals ; Anti-Infective Agents - isolation & purification ; Anti-Infective Agents - pharmacology ; Antibiotics ; Antibiotics (antibacterial agents, antifungal agents) ; Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents ; Antifungal activity ; Antimicrobial activity ; Antimicrobial agents ; Ants - chemistry ; Applied microbiology ; Atta ; Bacteria ; Biochemistry ; Biological and medical sciences ; Biomedical and Life Sciences ; Bodily Secretions - chemistry ; Candida albicans ; Candida albicans - drug effects ; Candidiasis ; Caproates - isolation & purification ; Caproates - pharmacology ; Caprylates - isolation & purification ; Caprylates - pharmacology ; citral ; Colonies ; Cuttings ; E coli ; Escherichia coli ; Escherichia coli - drug effects ; Filter paper ; Formicidae ; Fundamental and applied biological sciences. Psychology ; Geraniol ; Glands ; Indoleacetic Acids - isolation & purification ; Indoleacetic Acids - pharmacology ; Insects ; Ketones - isolation & purification ; Ketones - pharmacology ; Leaves ; Life Sciences ; Mandible ; Medical Microbiology ; Microbial Sensitivity Tests ; Microbiology ; Monoterpenes - isolation & purification ; Monoterpenes - pharmacology ; n-Hexane ; Nests ; octanoic acid ; Original Paper ; Pathogens ; Phenylacetates - isolation & purification ; Phenylacetates - pharmacology ; Plant Sciences ; Secretions ; Soil Science & Conservation ; Staphylococcus aureus ; Staphylococcus aureus - drug effects ; Studies ; Terpenes - isolation & purification ; Terpenes - pharmacology]]></subject><ispartof>Antonie van Leeuwenhoek, 2009-05, Vol.95 (4), p.295-303</ispartof><rights>Springer Science+Business Media B.V. 2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c520t-d3c08e9adecd3411d568dce8e84db62e743540fda79879cb213299f923fd038a3</citedby><cites>FETCH-LOGICAL-c520t-d3c08e9adecd3411d568dce8e84db62e743540fda79879cb213299f923fd038a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10482-009-9312-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10482-009-9312-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21304895$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19214771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Lima Mendonça, Adriana</creatorcontrib><creatorcontrib>da Silva, Carlos Eduardo</creatorcontrib><creatorcontrib>de Mesquita, Fernando Lucas Torres</creatorcontrib><creatorcontrib>da Silva Campos, Rousseau</creatorcontrib><creatorcontrib>Do Nascimento, Ruth R</creatorcontrib><creatorcontrib>de Azevedo Ximenes, Eulália Camelo Pessoa</creatorcontrib><creatorcontrib>Sant'Ana, Antônio Euzébio G</creatorcontrib><title>Antimicrobial activities of components of the glandular secretions of leaf cutting ants of the genus Atta</title><title>Antonie van Leeuwenhoek</title><addtitle>Antonie van Leeuwenhoek</addtitle><addtitle>Antonie Van Leeuwenhoek</addtitle><description>The secretions of the mandibular and metapleural glands of leaf cutting ants contain antimicrobial substances that protect the mutualistic fungal colony within the nest from attack by parasitic micro-organisms. The major constituents of these secretions (citral, 4-methyl-3-heptanol, 2-heptanone, 3-octanone, 4-methyl-2-heptanone, β-citronellol, geraniol, phenylacetic, indolacetic, hexanoic and octanoic acids were tested against resistant strains of the human pathogens, Escherichia coli, Staphylococcus aureus and Candida albicans. Assays were carried out using filter paper discs impregnated with either hexane or water solutions of the analytes in the concentration range 250-6,000 ng/μl. Although most of the tested compounds presented strong antibacterial and antifungal activities, citral, geraniol, 4-methyl-3-heptanol, hexanoic and octanoic acids were the most effective, particularly against C. albicans. The results suggest that these compounds may be of potential value as antibiotics in the treatment of human candidiasis.</description><subject>Animals</subject><subject>Anti-Infective Agents - isolation & purification</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antibiotics</subject><subject>Antibiotics (antibacterial agents, antifungal agents)</subject><subject>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</subject><subject>Antifungal activity</subject><subject>Antimicrobial activity</subject><subject>Antimicrobial agents</subject><subject>Ants - chemistry</subject><subject>Applied microbiology</subject><subject>Atta</subject><subject>Bacteria</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Bodily Secretions - chemistry</subject><subject>Candida albicans</subject><subject>Candida albicans - drug effects</subject><subject>Candidiasis</subject><subject>Caproates - isolation & purification</subject><subject>Caproates - pharmacology</subject><subject>Caprylates - isolation & purification</subject><subject>Caprylates - pharmacology</subject><subject>citral</subject><subject>Colonies</subject><subject>Cuttings</subject><subject>E coli</subject><subject>Escherichia coli</subject><subject>Escherichia coli - drug effects</subject><subject>Filter paper</subject><subject>Formicidae</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Geraniol</subject><subject>Glands</subject><subject>Indoleacetic Acids - isolation & purification</subject><subject>Indoleacetic Acids - pharmacology</subject><subject>Insects</subject><subject>Ketones - isolation & purification</subject><subject>Ketones - pharmacology</subject><subject>Leaves</subject><subject>Life Sciences</subject><subject>Mandible</subject><subject>Medical Microbiology</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Monoterpenes - isolation & purification</subject><subject>Monoterpenes - pharmacology</subject><subject>n-Hexane</subject><subject>Nests</subject><subject>octanoic acid</subject><subject>Original Paper</subject><subject>Pathogens</subject><subject>Phenylacetates - isolation & purification</subject><subject>Phenylacetates - pharmacology</subject><subject>Plant Sciences</subject><subject>Secretions</subject><subject>Soil Science & Conservation</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Studies</subject><subject>Terpenes - isolation & purification</subject><subject>Terpenes - pharmacology</subject><issn>0003-6072</issn><issn>1572-9699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkU1v1DAQhi0EotvCD-ACEVK5BcZ24o_jquJLqsQBera89mRxlTiL7VTi3-NtVhRxgJM9mud9PeOXkBcU3lIA-S5T6BRrAXSrOa2XR2RDe8laLbR-TDYAwFsBkp2R85xva6mFkk_JGdWMdlLSDQnbWMIUXJp3wY6NdSXchRIwN_PQuHk6zBFjua_Kd2z2o41-GW1qMrqEJczxvjeirfhSSoj7xv4pwLjkZluKfUaeDHbM-Px0XpCbD--_XX1qr798_Hy1vW5dz6C0njtQqK1H53lHqe-F8g4Vqs7vBEPZ8b6DwVupldRuxyhnWg-a8cEDV5ZfkDer7yHNPxbMxUwhOxzr5Dgv2QgJGqQU_wUZZZWSqoKv_wJv5yXFuoRhHBgIgCNEV6h-Zc4JB3NIYbLpp6FgjmmZNS1TQzDHtAxUzcuT8bKb0D8oTvFU4PIE2OzsOCQbXci_ubp7tdR95djK5dqKe0wPE_7r9VeraLCzsftUjW--MqieVNAOOuC_AGKBta0</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>de Lima Mendonça, Adriana</creator><creator>da Silva, Carlos Eduardo</creator><creator>de Mesquita, Fernando Lucas Torres</creator><creator>da Silva Campos, Rousseau</creator><creator>Do Nascimento, Ruth R</creator><creator>de Azevedo Ximenes, Eulália Camelo Pessoa</creator><creator>Sant'Ana, Antônio Euzébio G</creator><general>Dordrecht : Springer Netherlands</general><general>Springer Netherlands</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7SS</scope><scope>7X8</scope></search><sort><creationdate>20090501</creationdate><title>Antimicrobial activities of components of the glandular secretions of leaf cutting ants of the genus Atta</title><author>de Lima Mendonça, Adriana ; da Silva, Carlos Eduardo ; de Mesquita, Fernando Lucas Torres ; da Silva Campos, Rousseau ; Do Nascimento, Ruth R ; de Azevedo Ximenes, Eulália Camelo Pessoa ; Sant'Ana, Antônio Euzébio G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c520t-d3c08e9adecd3411d568dce8e84db62e743540fda79879cb213299f923fd038a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Anti-Infective Agents - isolation & purification</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Antibiotics</topic><topic>Antibiotics (antibacterial agents, antifungal agents)</topic><topic>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</topic><topic>Antifungal activity</topic><topic>Antimicrobial activity</topic><topic>Antimicrobial agents</topic><topic>Ants - chemistry</topic><topic>Applied microbiology</topic><topic>Atta</topic><topic>Bacteria</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Bodily Secretions - chemistry</topic><topic>Candida albicans</topic><topic>Candida albicans - drug effects</topic><topic>Candidiasis</topic><topic>Caproates - isolation & purification</topic><topic>Caproates - pharmacology</topic><topic>Caprylates - isolation & purification</topic><topic>Caprylates - pharmacology</topic><topic>citral</topic><topic>Colonies</topic><topic>Cuttings</topic><topic>E coli</topic><topic>Escherichia coli</topic><topic>Escherichia coli - drug effects</topic><topic>Filter paper</topic><topic>Formicidae</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Geraniol</topic><topic>Glands</topic><topic>Indoleacetic Acids - isolation & purification</topic><topic>Indoleacetic Acids - pharmacology</topic><topic>Insects</topic><topic>Ketones - isolation & purification</topic><topic>Ketones - pharmacology</topic><topic>Leaves</topic><topic>Life Sciences</topic><topic>Mandible</topic><topic>Medical Microbiology</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Monoterpenes - isolation & purification</topic><topic>Monoterpenes - pharmacology</topic><topic>n-Hexane</topic><topic>Nests</topic><topic>octanoic acid</topic><topic>Original Paper</topic><topic>Pathogens</topic><topic>Phenylacetates - isolation & purification</topic><topic>Phenylacetates - pharmacology</topic><topic>Plant Sciences</topic><topic>Secretions</topic><topic>Soil Science & Conservation</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Studies</topic><topic>Terpenes - isolation & purification</topic><topic>Terpenes - 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Academic</collection><jtitle>Antonie van Leeuwenhoek</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Lima Mendonça, Adriana</au><au>da Silva, Carlos Eduardo</au><au>de Mesquita, Fernando Lucas Torres</au><au>da Silva Campos, Rousseau</au><au>Do Nascimento, Ruth R</au><au>de Azevedo Ximenes, Eulália Camelo Pessoa</au><au>Sant'Ana, Antônio Euzébio G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimicrobial activities of components of the glandular secretions of leaf cutting ants of the genus Atta</atitle><jtitle>Antonie van Leeuwenhoek</jtitle><stitle>Antonie van Leeuwenhoek</stitle><addtitle>Antonie Van Leeuwenhoek</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>95</volume><issue>4</issue><spage>295</spage><epage>303</epage><pages>295-303</pages><issn>0003-6072</issn><eissn>1572-9699</eissn><coden>ANLEDR</coden><abstract>The secretions of the mandibular and metapleural glands of leaf cutting ants contain antimicrobial substances that protect the mutualistic fungal colony within the nest from attack by parasitic micro-organisms. The major constituents of these secretions (citral, 4-methyl-3-heptanol, 2-heptanone, 3-octanone, 4-methyl-2-heptanone, β-citronellol, geraniol, phenylacetic, indolacetic, hexanoic and octanoic acids were tested against resistant strains of the human pathogens, Escherichia coli, Staphylococcus aureus and Candida albicans. Assays were carried out using filter paper discs impregnated with either hexane or water solutions of the analytes in the concentration range 250-6,000 ng/μl. Although most of the tested compounds presented strong antibacterial and antifungal activities, citral, geraniol, 4-methyl-3-heptanol, hexanoic and octanoic acids were the most effective, particularly against C. albicans. The results suggest that these compounds may be of potential value as antibiotics in the treatment of human candidiasis.</abstract><cop>Dordrecht</cop><pub>Dordrecht : Springer Netherlands</pub><pmid>19214771</pmid><doi>10.1007/s10482-009-9312-0</doi><tpages>9</tpages></addata></record> |
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| issn | 0003-6072 1572-9699 |
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| subjects | Animals Anti-Infective Agents - isolation & purification Anti-Infective Agents - pharmacology Antibiotics Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antifungal activity Antimicrobial activity Antimicrobial agents Ants - chemistry Applied microbiology Atta Bacteria Biochemistry Biological and medical sciences Biomedical and Life Sciences Bodily Secretions - chemistry Candida albicans Candida albicans - drug effects Candidiasis Caproates - isolation & purification Caproates - pharmacology Caprylates - isolation & purification Caprylates - pharmacology citral Colonies Cuttings E coli Escherichia coli Escherichia coli - drug effects Filter paper Formicidae Fundamental and applied biological sciences. Psychology Geraniol Glands Indoleacetic Acids - isolation & purification Indoleacetic Acids - pharmacology Insects Ketones - isolation & purification Ketones - pharmacology Leaves Life Sciences Mandible Medical Microbiology Microbial Sensitivity Tests Microbiology Monoterpenes - isolation & purification Monoterpenes - pharmacology n-Hexane Nests octanoic acid Original Paper Pathogens Phenylacetates - isolation & purification Phenylacetates - pharmacology Plant Sciences Secretions Soil Science & Conservation Staphylococcus aureus Staphylococcus aureus - drug effects Studies Terpenes - isolation & purification Terpenes - pharmacology |
| title | Antimicrobial activities of components of the glandular secretions of leaf cutting ants of the genus Atta |
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