Peptide YY inhibits the growth of Barrett's esophageal adenocarcinoma in vitro

Peptide YY (PYY) is an endogenous gut hormone that inhibits the growth of certain cancers. Adenocarcinoma of the esophagus usually arises from Barrett's esophagus. We hypothesized that treatment of Barrett's adenocarcinoma with PYY would result in decreased proliferation. Barrett's ca...

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Veröffentlicht in:	The American journal of surgery 2004-11, Vol.188 (5), p.516-519
Hauptverfasser:	McFadden, David W., Riggs, Dale R., Jackson, Barbara J., Vona-Davis, Linda
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - pathology Analysis of Variance Apoptosis Apoptosis - drug effects Barrett Esophagus - pathology Barrett's adenocarcinoma Biological and medical sciences Breast cancer Cancer therapies Cell culture Cell growth Cell Proliferation - drug effects Cellular inhibition Chemotherapy Colon Cytokines Esophageal Neoplasms - pathology Flow cytometry General aspects Humans In Vitro Techniques Medical sciences Mutation Peptide YY Peptide YY - pharmacology Probability Proteins Risk Factors Sensitivity and Specificity Tumor Cells, Cultured Tumors Vitamin E
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Zusammenfassung:	Peptide YY (PYY) is an endogenous gut hormone that inhibits the growth of certain cancers. Adenocarcinoma of the esophagus usually arises from Barrett's esophagus. We hypothesized that treatment of Barrett's adenocarcinoma with PYY would result in decreased proliferation. Barrett's cancer cell lines (BIC and SEG-1) were treated with PYY (3-36) at 500 pmol/mL. Viability was measured by MTT at 24 and 72 hours. Apoptosis and necrosis was evaluated by flow cytometry. PYY reduced proliferation in SEG-1 cells at 24 hours (21.2% ± 3.4%, P
ISSN:	0002-9610 1879-1883
DOI:	10.1016/j.amjsurg.2004.07.009