Effects of Different Types of Exercise Training Followed by Detraining on Endothelium-Dependent Dilation in Patients With Recent Myocardial Infarction
In coronary artery disease, exercise training (ET) is associated with an improvement in endothelial function, but little is known about the relative effect of different types of training. The purpose of this study was to prospectively evaluate the effect of different types of ET on endothelial funct...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2009-03, Vol.119 (12), p.1601-1608 |
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| creator | VONA, M CODELUPPI, G. M IANNINO, T FERRARI, E BOGOUSSLAVSKY, J VON SEGESSER, L. K |
| description | In coronary artery disease, exercise training (ET) is associated with an improvement in endothelial function, but little is known about the relative effect of different types of training. The purpose of this study was to prospectively evaluate the effect of different types of ET on endothelial function in 209 patients after a first recent acute myocardial infarction.
Endothelial function was evaluated before and after 4 weeks of different types of ET and after 1 month of detraining by measuring flow-mediated dilation and von Willebrand factor levels at baseline and after ET. Patients were randomized into 4 groups: group 1, aerobic ET (n=52); group 2, resistance training (n=54); group 3, resistance plus aerobic training (n=53); and group 4, no training (n=50). At baseline, flow-mediated dilation was 4.5+/-2.6% in group 1, 4.01+/-1.6% in group 2, 4.4+/-4% in group 3, and 4.3+/-2.3% in group 4 (P=NS). After ET, flow-mediated dilation increased to 9.9+/-2.5% in group 1, 10.1+/-2.6% in group 2, and 10.8+/-3% in group 3 (P |
| doi_str_mv | 10.1161/CIRCULATIONAHA.108.821736 |
| format | Article |
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Endothelial function was evaluated before and after 4 weeks of different types of ET and after 1 month of detraining by measuring flow-mediated dilation and von Willebrand factor levels at baseline and after ET. Patients were randomized into 4 groups: group 1, aerobic ET (n=52); group 2, resistance training (n=54); group 3, resistance plus aerobic training (n=53); and group 4, no training (n=50). At baseline, flow-mediated dilation was 4.5+/-2.6% in group 1, 4.01+/-1.6% in group 2, 4.4+/-4% in group 3, and 4.3+/-2.3% in group 4 (P=NS). After ET, flow-mediated dilation increased to 9.9+/-2.5% in group 1, 10.1+/-2.6% in group 2, and 10.8+/-3% in group 3 (P<0.01 versus baseline for all groups); it also increased in group 4 but to a much lesser extent (to 5.1+/-2.5%; P<0.01 versus trained groups). The von Willebrand factor level after ET decreased by 16% (P<0.01) similarly in groups 1, 2, and 3 but remained unchanged in group 4. Detraining returned flow-mediated dilation to baseline levels (P<0.01 versus posttraining).
In patients with recent acute myocardial infarction, ET was associated with improved endothelial function independently of the type of training, but this effect disappeared after 1 month of detraining.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/CIRCULATIONAHA.108.821736</identifier><identifier>PMID: 19289636</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cardiovascular system ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Endothelium, Vascular - physiopathology ; Exercise Therapy - methods ; Exercise Therapy - standards ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Myocardial Infarction - physiopathology ; Myocardial Infarction - rehabilitation ; Pharmacology. Drug treatments ; Time Factors ; Treatment Outcome ; Vasodilation ; Vasodilator agents. Cerebral vasodilators ; von Willebrand Factor - analysis</subject><ispartof>Circulation (New York, N.Y.), 2009-03, Vol.119 (12), p.1601-1608</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-e8b66db4f62c98a18a86274a75293f1839fedfb991c77c53174e3003b511141e3</citedby><cites>FETCH-LOGICAL-c439t-e8b66db4f62c98a18a86274a75293f1839fedfb991c77c53174e3003b511141e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3687,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21374588$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19289636$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VONA, M</creatorcontrib><creatorcontrib>CODELUPPI, G. M</creatorcontrib><creatorcontrib>IANNINO, T</creatorcontrib><creatorcontrib>FERRARI, E</creatorcontrib><creatorcontrib>BOGOUSSLAVSKY, J</creatorcontrib><creatorcontrib>VON SEGESSER, L. K</creatorcontrib><title>Effects of Different Types of Exercise Training Followed by Detraining on Endothelium-Dependent Dilation in Patients With Recent Myocardial Infarction</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>In coronary artery disease, exercise training (ET) is associated with an improvement in endothelial function, but little is known about the relative effect of different types of training. The purpose of this study was to prospectively evaluate the effect of different types of ET on endothelial function in 209 patients after a first recent acute myocardial infarction.
Endothelial function was evaluated before and after 4 weeks of different types of ET and after 1 month of detraining by measuring flow-mediated dilation and von Willebrand factor levels at baseline and after ET. Patients were randomized into 4 groups: group 1, aerobic ET (n=52); group 2, resistance training (n=54); group 3, resistance plus aerobic training (n=53); and group 4, no training (n=50). At baseline, flow-mediated dilation was 4.5+/-2.6% in group 1, 4.01+/-1.6% in group 2, 4.4+/-4% in group 3, and 4.3+/-2.3% in group 4 (P=NS). After ET, flow-mediated dilation increased to 9.9+/-2.5% in group 1, 10.1+/-2.6% in group 2, and 10.8+/-3% in group 3 (P<0.01 versus baseline for all groups); it also increased in group 4 but to a much lesser extent (to 5.1+/-2.5%; P<0.01 versus trained groups). The von Willebrand factor level after ET decreased by 16% (P<0.01) similarly in groups 1, 2, and 3 but remained unchanged in group 4. Detraining returned flow-mediated dilation to baseline levels (P<0.01 versus posttraining).
In patients with recent acute myocardial infarction, ET was associated with improved endothelial function independently of the type of training, but this effect disappeared after 1 month of detraining.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular system</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Exercise Therapy - methods</subject><subject>Exercise Therapy - standards</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Myocardial Infarction - rehabilitation</subject><subject>Pharmacology. Drug treatments</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Vasodilation</subject><subject>Vasodilator agents. Cerebral vasodilators</subject><subject>von Willebrand Factor - analysis</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc9uEzEQxi0EomnhFZA50NuGtb3rP8coSWmkQFGViuPK6x1TI8cO9kaQF-F565AA4jQz3_xmRpoPobeknhLCyfv56n7-sJ5tVnefZrezKanlVFIiGH-GJqSlTdW0TD1Hk7quVSUYpRfoMudvpeRMtC_RBVFUKs74BP1aWgtmzDhavHAlTxBGvDns4Le0_AnJuAx4k7QLLnzFN9H7-AMG3B_wAsY_cgx4GYY4PoJ3-221gB2E4bhq4bweXWm7gD-XrGgZf3HjI74HcwQ-HqLRaXDa41WwOpkj_Qq9sNpneH2OV-jhZrmZ31bruw-r-WxdmYapsQLZcz70jeXUKKmJ1JJT0WjRUsUskUxZGGyvFDFCmJYR0QCra9a3hJCGALtC16e9uxS_7yGP3dZlA97rAHGfOy5qqVouC6hOoEkx5wS22yW31enQkbo7mtL9b0qRZXcypcy-OR_Z91sY_k2eXSjAuzOgs9HeJh3K0_9ylDDRtFKyJ53BmMg</recordid><startdate>20090331</startdate><enddate>20090331</enddate><creator>VONA, M</creator><creator>CODELUPPI, G. M</creator><creator>IANNINO, T</creator><creator>FERRARI, E</creator><creator>BOGOUSSLAVSKY, J</creator><creator>VON SEGESSER, L. K</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090331</creationdate><title>Effects of Different Types of Exercise Training Followed by Detraining on Endothelium-Dependent Dilation in Patients With Recent Myocardial Infarction</title><author>VONA, M ; CODELUPPI, G. M ; IANNINO, T ; FERRARI, E ; BOGOUSSLAVSKY, J ; VON SEGESSER, L. K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-e8b66db4f62c98a18a86274a75293f1839fedfb991c77c53174e3003b511141e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular system</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Exercise Therapy - methods</topic><topic>Exercise Therapy - standards</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Myocardial Infarction - rehabilitation</topic><topic>Pharmacology. Drug treatments</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Vasodilation</topic><topic>Vasodilator agents. Cerebral vasodilators</topic><topic>von Willebrand Factor - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VONA, M</creatorcontrib><creatorcontrib>CODELUPPI, G. M</creatorcontrib><creatorcontrib>IANNINO, T</creatorcontrib><creatorcontrib>FERRARI, E</creatorcontrib><creatorcontrib>BOGOUSSLAVSKY, J</creatorcontrib><creatorcontrib>VON SEGESSER, L. K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VONA, M</au><au>CODELUPPI, G. M</au><au>IANNINO, T</au><au>FERRARI, E</au><au>BOGOUSSLAVSKY, J</au><au>VON SEGESSER, L. K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Different Types of Exercise Training Followed by Detraining on Endothelium-Dependent Dilation in Patients With Recent Myocardial Infarction</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2009-03-31</date><risdate>2009</risdate><volume>119</volume><issue>12</issue><spage>1601</spage><epage>1608</epage><pages>1601-1608</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>In coronary artery disease, exercise training (ET) is associated with an improvement in endothelial function, but little is known about the relative effect of different types of training. The purpose of this study was to prospectively evaluate the effect of different types of ET on endothelial function in 209 patients after a first recent acute myocardial infarction.
Endothelial function was evaluated before and after 4 weeks of different types of ET and after 1 month of detraining by measuring flow-mediated dilation and von Willebrand factor levels at baseline and after ET. Patients were randomized into 4 groups: group 1, aerobic ET (n=52); group 2, resistance training (n=54); group 3, resistance plus aerobic training (n=53); and group 4, no training (n=50). At baseline, flow-mediated dilation was 4.5+/-2.6% in group 1, 4.01+/-1.6% in group 2, 4.4+/-4% in group 3, and 4.3+/-2.3% in group 4 (P=NS). After ET, flow-mediated dilation increased to 9.9+/-2.5% in group 1, 10.1+/-2.6% in group 2, and 10.8+/-3% in group 3 (P<0.01 versus baseline for all groups); it also increased in group 4 but to a much lesser extent (to 5.1+/-2.5%; P<0.01 versus trained groups). The von Willebrand factor level after ET decreased by 16% (P<0.01) similarly in groups 1, 2, and 3 but remained unchanged in group 4. Detraining returned flow-mediated dilation to baseline levels (P<0.01 versus posttraining).
In patients with recent acute myocardial infarction, ET was associated with improved endothelial function independently of the type of training, but this effect disappeared after 1 month of detraining.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>19289636</pmid><doi>10.1161/CIRCULATIONAHA.108.821736</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Endothelium, Vascular - physiopathology Exercise Therapy - methods Exercise Therapy - standards Female Humans Male Medical sciences Middle Aged Myocardial Infarction - physiopathology Myocardial Infarction - rehabilitation Pharmacology. Drug treatments Time Factors Treatment Outcome Vasodilation Vasodilator agents. Cerebral vasodilators von Willebrand Factor - analysis |
| title | Effects of Different Types of Exercise Training Followed by Detraining on Endothelium-Dependent Dilation in Patients With Recent Myocardial Infarction |
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