Increased incidence of the Hfe mutation in amyotrophic lateral sclerosis and related cellular consequences

The etiology of amyotrophic lateral sclerosis (ALS) is unknown. The presence of mutations in the superoxide dismutase gene (SOD1) has led to theories regarding a role for oxidative stress in the pathogenesis of this disease. A primary cause of oxidative stress is perturbations in cellular iron homeo...

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Veröffentlicht in:	Journal of the neurological sciences 2004-12, Vol.227 (1), p.27-33
Hauptverfasser:	Wang, Xin-Sheng, Lee, Sang, Simmons, Zachary, Boyer, Philip, Scott, Kevin, Liu, Wenlei, Connor, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Age of Onset Amino Acids - genetics Amyotrophic Lateral Sclerosis - blood Amyotrophic Lateral Sclerosis - epidemiology Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - metabolism Biological and medical sciences Blotting, Western - methods Case-Control Studies Cell Line, Tumor Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases DNA Mutational Analysis - methods Female Gene Frequency Genotype Hemochromatosis Protein Hfe mutation Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - metabolism Humans Incidence Iron Male Medical sciences Membrane Proteins - genetics Membrane Proteins - metabolism Middle Aged Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Mutation - genetics Neuroblastoma Neurology Oxidative stress Retrospective Studies Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger SOD1 Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Transfection - methods
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